EwaBalajiAlbertMicheleProject MMarc OBrienBen GaydosBoston ProgressArts CollectiveJanetJonahAlexBeckyKarenKaren SteinA Better World byDesignDesign ThatMattersD-LabNadiaSandraUC BerkeleyRachelKopernikElizabethDonnyMITJackieAppropediaOrgs TEL wants toor couldwork withThe TEL TeamProfessionalNetworking HubsDesigners,Coders, etc.WakaNokeroSelcoEssmartSameerEliseDianaJICARaikiTranslators WithoutBordersEngineering forChangeSteveLesley UniversityJohnJoOperationGroundswellPATHThe TEL Network
SystemsThinkingsystemselementsinterrelationspurposefeedbackCommunicationssimpled the coreuse analogiesconcreteunexpectedexpose knowledgegapsBehavorial Changedirect the ridersend destinationpostcardsd bright spotsscriptmomotivate theelephantshrink the changed the feelingappeal to idenityengineer earlysuccesseshelp people growshape the pathmake it socialImpactknow yourmissionmeasure theright thingmeasure it wellverbtargetoutcomeimpact from a thingis it needed?will it get to thosewho need it?will they use itcorrectly?leverage pointstrapsopportunitiesdesignthinkingask stupidquestionsmake hope visiblejump fencessmartrecombinationsabductivereasoningdriftfail early, fail oftenharvest ideas, editapplications compellingexperienceframeworkgenerativemetaphorscombine familiarand surprisingembraceconstraintsforcedprioritizationcreate mysterycrediblehuman-scaleprincipleauthorityantiauthoritythe Sinatra testtestablecredentialsthe Velcro theory ofmemoryblacemotionviolate schemassolution focustweenvirstoriesbuild a culturestocksflows
34links connecting the ki neighbors of node i to each other, representshow nodes interconnect26. The Ci value of 0.24 measured for our net-work indicates strong clustering27. Nodes with the largest numbers oflinks were actin (33 interactions), PtdIns(4,5)P2 (20), SLC9A3R2 (12),CALM (9), RDX (8) and Ca2+ (8).ERM proteins28, and binding was indeed stronger tothreonine-to-aspartate mutation that mimics the actiphorylation (Fig. 5b and Supplementary Fig. 8). In bucilia, RDX is activated by PtdIns(4,5)P2 and phosphorylain a narrow band above basal tapers, at the site of thePtdlns(4,5)P2PLS1ANXA6Known interactionBundle protein paralogHypotheticalMolecules perstereocilium10510410310210PIP4K2BFigure 4 Interaction network for hproteins. Symbols (nodes) represenproteins or second messengers; onwith two or more interactions are pthe exception of OCM and CALB2.labels indicate deafness-associateNode colors indicate functional cla(same key as in Fig. 2b); node symrepresents protein abundance in bPtdIns(4,5)P2 and cyclic AMP arediamond node symbols. Solid linksinteractions validated with literatuSupplementary Table 3 lists all intevidence. Dotted links correspondinvolving paralogs of bundle proteilinks represent hypothetical interaexample, SLC9A3R2 interactionsThe layout of the plot is controlleddensity of links between nearby nodistribution of nodes and links in twell by a power law, which indicatplot contains a few highly connect(hubs) and many other less-connecSupplementary Figure 7 reproducefigure with each link hyperlinked treference supporting the interactio
TermsA Social Network: consists of all the connections and ties withina group or collection of groupsA group is a collection of individuals defined by a commonattribute (it need not contain information about connections)
To figure out howa disease is spreading,look for hubs.
With Bird Flu, Right Now, Anything IsPossibleApril 19, 2013 5:36 AMby RICHARD KNOXListen to the StoryMorning Edition 4 min 22 secChinaFotoPress/Getty ImagesiAn international dream team of flu experts assembled in Chinatoday.Underscoring the urgency that public health agencies feel about theemergence of a new kind of bird flu, the team is headed by Dr. KeijiFukuda, the World Health Organizations top influenza scientist.Before he left Geneva, Fukuda explained the wide-open nature of