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Dna

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Transcript

  • 1. DNA Structure and Replication
  • 2. Transformation: Robert Griffith (1928)
  • 3. DNA is the Transformer: Avery (1944)
  • 4. Chromosomes and DNA
  • 5. DNA has 4 Bases
  • 6. Four DNA Bases Adenine Thymine NH2 N H 3C N NH Guanine N NH NH NH O N O Cytosine NH2 NH N O N NH2 NH O
  • 7. The Sugar HO OH O OH Deoxyribose
  • 8. The Nucleotides A O HO NH2 P N C N O N O N O HO OH P HO P N O O OH OH T O G O N O OH O NH2 N N O NH O H 3C NH O N NH2 HO P OH O N O OH OH OH O
  • 9. Adenine pairs with Thymine Hydrogen Bonding
  • 10. Guanine pairs with Cytosine Hydrogen Bonding
  • 11. DNA
  • 12. Genes and Base Pairs: A Comparison Genes (estimated) Base Pairs Yeast 6,000 12 million Round Worm 19,000 99 million Mouse 40,000 3 billion Fruit Fly 13,600 165 million Human 40,000 3 billion Species (Saccharomyces cerevisiae) (Caenorhabditis elegans) (Mus musculus) (Drosophila melanogaster) (Homo sapiens)
  • 13. The “Central Dogma”
  • 14. Possible Modes of DNA Replication
  • 15. Replication: 5’ to 3’ Direction ONLY Continuous replication on one strand Discontinuous replication on one strand
  • 16. DNA Replication is Catalyzed by Enzymes
  • 17. DNA Polymerase Adds Complementary Bases
  • 18. DNA Polymerase Sees Errors
  • 19. DNA Polymerase Repairs Errors