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A joint venture between Rajiv Gandhi Centre for Biotechnology (RGCB), Trivandrum & Kreara Solutions,Technopark
Rajiv Gandhi Centre for Biotechnology <ul><li>Established on November 18 th  2002 </li></ul><ul><li>Exclusively devoted to...
KREARA <ul><li>Established on April 24 th  2004 </li></ul><ul><li>Contract Research Services to Pharmaceutical companies <...
FOCUS Biomedical Informatics Bio-informatics Clinical informatics Software tools for enhanced research Clinical Trials Pha...
LIMS LABOROTARY INFORMATION MANAGEMENT SYSTEM Laboratory Personal Management External Vendors Lab Equipments
Metabolic Pathways Protein Protein Interactions Micro Array Databases Protein Structure Databases Protein Sequence Databas...
BIOINFORMATICS DNA  Sequence Analysis Genome  Annotation Gene Expression  Analysis Protein Expression  Analysis Mutation A...
CLINICAL INFORMATICS Medical Data Mining  Electronic Medical Records Decision Support Systems Hospital Information Systems...
BIOMEDICAL SERVICES Micro Array Data Processing Mutation Analysis Molecular Modeling Molecular Dynamics Simulations In Sil...
Genomic Biology Large Molecular targets Bioinformatics Assays Computational Chemistry Small Molecules Cheminformatics In S...
ECONOMICS OF  IN SILICO CLINICAL TRIALS In Vivo In Vitro In Silico
RGCB <ul><li>1200 Square foot of modular offices </li></ul><ul><li>High end servers and workstations </li></ul><ul><li>Bio...
INCENTIVES Intensive bioinformatics component of research Significant cost reduction by following an in silico approach Su...
PHASE ONE GOALS <ul><li>A user friendly application, with intuitive menu/dialog boxes, that will enable laboratory biologi...
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Kreara - Preclinical research services

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Transcript of "Kreara - Preclinical research services"

  1. 1. A joint venture between Rajiv Gandhi Centre for Biotechnology (RGCB), Trivandrum & Kreara Solutions,Technopark
  2. 2. Rajiv Gandhi Centre for Biotechnology <ul><li>Established on November 18 th 2002 </li></ul><ul><li>Exclusively devoted to Biotechnology </li></ul><ul><li>Precise focus on translational research </li></ul><ul><li>Six highly focussed research departments </li></ul><ul><li>Regional Facility for Genetic Fingerprinting </li></ul><ul><li>Vaccine Development and Bioinformatics </li></ul><ul><li>Bio-prospecting on clinically bioactive compounds </li></ul><ul><li>Improvements in human health and well being </li></ul><ul><li>Safer and more globally competitive spices </li></ul><ul><li>Industrial growth through biotechnology </li></ul><ul><li>Human resource development </li></ul>
  3. 3. KREARA <ul><li>Established on April 24 th 2004 </li></ul><ul><li>Contract Research Services to Pharmaceutical companies </li></ul><ul><li>Clinical Data management and Biometrics </li></ul><ul><li>Interactive voice and web response systems </li></ul><ul><li>Safety and Efficacy Analysis for Clinical trials </li></ul><ul><li>Quality of Life and Interim analysis </li></ul><ul><li>Patient Diaries and Compliance </li></ul><ul><li>Agile Software Development </li></ul><ul><li>Software testing and Quality Control </li></ul><ul><li>Market Access Services </li></ul><ul><li>Patient Reported Outcome Research </li></ul><ul><li>Post Marketing Surveillance </li></ul>
  4. 4. FOCUS Biomedical Informatics Bio-informatics Clinical informatics Software tools for enhanced research Clinical Trials Phase I - IV Bioequivalence studies Laboratory Information Management System Biological Databases Biomedical Services
  5. 5. LIMS LABOROTARY INFORMATION MANAGEMENT SYSTEM Laboratory Personal Management External Vendors Lab Equipments
  6. 6. Metabolic Pathways Protein Protein Interactions Micro Array Databases Protein Structure Databases Protein Sequence Databases Genome Databases BIOLOGICAL DATABASES Meta Databases Primary Sequence Databases DATABASE BROWSER
  7. 7. BIOINFORMATICS DNA Sequence Analysis Genome Annotation Gene Expression Analysis Protein Expression Analysis Mutation Analysis Cancer Protein Structure Prediction Protein to Protein Docking Modular application pipeline for systematic analysis of data from routine DNA sequencing projects.
  8. 8. CLINICAL INFORMATICS Medical Data Mining Electronic Medical Records Decision Support Systems Hospital Information Systems Laboratory Information Systems Statistical Safety and Efficacy Analysis Medical Coding of Adverse Events and Concomitant medication Biological databases An Artificial Neural Network based predictive model for treatment outcome in Acute Myeloid leukemia (AML). Laboratory Information Management Systems Medical Writing of study reports
  9. 9. BIOMEDICAL SERVICES Micro Array Data Processing Mutation Analysis Molecular Modeling Molecular Dynamics Simulations In Silico Clinical Trials
  10. 10. Genomic Biology Large Molecular targets Bioinformatics Assays Computational Chemistry Small Molecules Cheminformatics In Silico PAVING WAY FOR IN SILICO CLINICAL TRIALS
  11. 11. ECONOMICS OF IN SILICO CLINICAL TRIALS In Vivo In Vitro In Silico
  12. 12. RGCB <ul><li>1200 Square foot of modular offices </li></ul><ul><li>High end servers and workstations </li></ul><ul><li>Biotechnology software licenses </li></ul><ul><li>State of the art laboratory equipments </li></ul><ul><li>2000 Square foot of modular offices </li></ul><ul><li>High end servers and workstations </li></ul><ul><li>SPSS, SAS and Visual Studio 2008 </li></ul><ul><li>Strategically located in Technopark </li></ul>KREARA <ul><li>Sequence analysis </li></ul><ul><li>Molecular Modeling </li></ul><ul><li>Molecular dynamics </li></ul><ul><li>Microarray data analysis </li></ul><ul><li>Clinical areas </li></ul><ul><li>Marketing presence in USA and EU </li></ul><ul><li>Clinical Data management </li></ul><ul><li>Biometric Services </li></ul><ul><li>Experienced team of SW engineers </li></ul><ul><li>Project management services </li></ul>SYNERGIES & LOGISTICS
  13. 13. INCENTIVES Intensive bioinformatics component of research Significant cost reduction by following an in silico approach Support the wet laboratory research teams by providing these services Development of new/improved software and computational pipelines for addressing challenges in bioinformatics and clinical informatics is warranted as there are viable “gaps” in the bio-informatics market.
  14. 14. PHASE ONE GOALS <ul><li>A user friendly application, with intuitive menu/dialog boxes, that will enable laboratory biologists, to manage a variety of types of laboratory data. </li></ul><ul><li>An ANN-based software that can predict prognosis in AML patients, taking as input only the common clinico-pathological parameters recorded at clinical presentation. </li></ul><ul><li>A software pipeline for comprehensive analysis of raw sequence data culminating in protein structure level analysis in possible cases. </li></ul>
  15. 15. THANK YOU FOR LISTENING
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