T-cell receptor excision circles: Telling how old T-cells are

1. T cell Receptor Excision Circles (TRECs) in Thymocyte Development Anna Merca VIV, SMI Fall 2006

3. Markers in lymphocyte development

7. TRD & TRA gene rearrangement Hazenberg et al 2001

8. TRB gene rearrangement Hazenberg et al 2001

9. Double Positive Cells interact with Cortical Epithelial Cells Immunobiology 5 th edition

10. Double Positive Cell Develops into Single Positive CD8+ T cells Immunobiology 5 th edition

11. Double Positive Cell Develops into Single Positive CD4+ T cells Immunobiology 5 th edition

13. Model of Human αβ and γδ Thymocyte development Hazenberg et al 2001 TCR β exp CD 34 exp 34 + 1a- 34 + 1a + 34 + 4 + 34 - 4 + 4 + 8 α + β - 8 β + 3 - γδ TCR + αβ TCR CD8 SP CD4 SP γδ potential β selection

15. Factors affecting TREC content Hazenberg et al 2001