Calorie restriction alone has been demonstrated in mice to impair seizure susceptibility. this may activate ATP sensitive potassium channels that may critically be involved in the regulation of seizure activity.
In 2003, a Cochrane review of the published literature found there were no randomised controlled trials on the ketogenic diet.
The review concluded that there was "no reliable evidence from randomised controlled trials to support the use of ketogenic diets for people with epilepsy" and stated that the diet was merely " a possible option" in the treatment of intractable epilepsy
the ketogenic diet group were further randomised to receive either the MCT diet or the classical diet ; results showed there was no significant difference in the responder rates or mean reduction in seizure frequency between the two groups.
Neal EG, Chaffe HM, Schwartz RH et al. A randomised controlled trial of classical and medium chain triglyceride ketogenic diets in the treatment of childhood epilepsy. Epilepsia 2008;
Case reports on two children indicate a possible use in treating astrocytomas ,
Autism, depression, migraine headaches, polycystic ovary syndrome , and type 2 diabetes mellitus have been shown to benefit in small case studies.
uncontrolled clinical trials and studies in animal models has shown that the ketogenic diet can provide symptomatic and disease-modifying activity in a broad range of neurodegenerative disorders including amyotrophic lateral sclerosis , Alzheimer’s disease and Parkinson’s disease , and may be protective in traumatic brain injury and stroke
As of 2008 [update] , there is not sufficient evidence to support the use of the ketogenic diet as a treatment for these conditions