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Thrombosis Class05
Thrombosis Class05
Thrombosis Class05
Thrombosis Class05
Thrombosis Class05
Thrombosis Class05
Thrombosis Class05
Thrombosis Class05
Thrombosis Class05
Thrombosis Class05
Thrombosis Class05
Thrombosis Class05
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Thrombosis Class05

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  • 1. Therapeutics of Cardiovascular Diseases <ul><li>Thrombosis and Haemostasis </li></ul><ul><li>2008 </li></ul><ul><li>Dr. George Hsiao </li></ul>
  • 2. &nbsp;
  • 3. <ul><li>Principles of haemostasis </li></ul><ul><li>The three stages invoved in haemostasis are blood vessel constriction , formation of a platelet plug , and formation of a clot . </li></ul><ul><li>Coagulation vs Platelet </li></ul>
  • 4. &nbsp;
  • 5. <ul><li>Thrombosis </li></ul><ul><li>Thrombosis is the pathological formation of a clot known as a thrombus. </li></ul><ul><li>Arterial occlusion , which may lead to myocardial infarction, stroke, and peripheral ischemia. </li></ul><ul><li>Venous occlusion , which may lead to deep venous thrombosis and pulmonary embolism. </li></ul>
  • 6. &nbsp;
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  • 8. &nbsp;
  • 9. <ul><li>Anticoagulants </li></ul><ul><li>Vitamin K antagonists </li></ul><ul><li>Warfarin, acenocoumarol (nicoumalone), and phenindione are examples of vitamin K antagonists. </li></ul><ul><li>Mechanism of action: Vitamin K antagonists block the reduction of vitamin K epoxide, which is necessary for its action as a cofactor in the synthesis of factors II, VII, IX, and X. </li></ul><ul><li>Heparin and the low-molecular weight heparins </li></ul><ul><li>Mechanism of action: Heparin activates antithrombin III, which limits blood clotting by inactivating thrombin and factor X. Heparin also inhibits platelet aggregation, possibly as a result of inhibiting thrombin. Low-molecular weight heparins are simply fragments of heparin which exhibit very similar activity to heparin. </li></ul><ul><li>Hirudins </li></ul><ul><li>Mechanism of action: Derived from the medical leech, hirudin, or rather its recombinant derivatives, desirudin and lepirudin, inactivate thrombin. </li></ul>
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