522psychdepre08[2]

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522psychdepre08[2]

  1. 1. <ul><li>Psychopharmacology </li></ul><ul><li>George Hsiao </li></ul><ul><li>2008 </li></ul>
  2. 2. <ul><li>*Most antidepressants exert important actions on the metabolism of monoamine neurotransmitters , particularly norepinephrine and serotonin. </li></ul><ul><li>*Mania is treated with antipsychotic drugs or lithium salts (sedative properties: mood-stabilizing properties) or carbamazepine . </li></ul>
  3. 5. Mercy killing <ul><li>* 嚴重性憂鬱症患者可能有妄想或幻覺 , 認為生不如死 , 又不忍心自己留下親人繼續受苦 , 因此設法殺害親人後再自行了斷 . </li></ul><ul><li>*Mania is characterized by excessive elation ( 激昂 ), severe insomnia ( 失眠 ), hyperactivity, typically tinged with dysphoria ( 煩躁不安 ) or marked by irritability, uncontrollable speech and activity, and impaired judgment. </li></ul>
  4. 6. Need Drugs?
  5. 7. Normal State
  6. 8. Monoamine theory (iproniazid, 1950-irreversible MAO I) [NE] low Depressive State
  7. 9. Biosynthesis of Neurotransmitters (acetylcholine and monoamines)
  8. 10. Projections of Norepinephrine Containing Neurons in the Locus Coeruleus
  9. 11. [NE] Treatment State (I)
  10. 12. [NE] Treatment State (II) *Increase [NE], [5-HT] or [DA]
  11. 13. Monoamine transporter NE
  12. 14. Serotonin (5-HT) Transporter Polymorphism Missense mutation Obsessive-compulsive disorder (Molecular Psychiatry 2003: 8, 933-936)
  13. 15. Autoreceptor Desensitization
  14. 17. 3 5 4 1 2 R S R N R D

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