Safe and successful restriction of transfusion


Published on

Published in: Health & Medicine, Business
  • Be the first to comment

  • Be the first to like this

No Downloads
Total views
On SlideShare
From Embeds
Number of Embeds
Embeds 0
No embeds

No notes for slide

Safe and successful restriction of transfusion

  1. 1. Safe and Successful Restriction of Transfusionin Burn Patients Peter Kwan, BSc (Eng), MD, Manuel Gomez, MD, MSc, Robert Cartotto, MD, FRCS(C) An acceptable strategy for transfusion of burn patients has not been specifically identified. In 1999, we empirically adopted a hemoglobin (Hb) transfusion trigger of 7.0 g/dl or greater in our burn center. The purpose of this study was to evaluate the effects of this re- strictive transfusion strategy. Retrospective comparison of adults with 20% or greater TBSA treated from 1999 to 2004 (restrictive group; REST) with patients treated before our adoption of the restrictive transfusion strategy (1997–1998: liberal group; LIB). The REST group (n 135, age 42 17 years, %TBSA burn 37 14, and 26% incidence of inhalation injury) did not differ significantly from the LIB group (n 37, age 42 16 years, %TBSA burn 38 17, and 35% inhalation injury). The Hb triggering a transfusion was 7.1 1.2 g/dl in the REST group, compared with 9.2 2.1 g/dl in the LIB group (P < .001). The REST group received significantly fewer units of blood per day than the LIB Group. Pa- tients in the REST group appeared to have significantly better organ function, and there were no differences between the groups in the incidence of acute myocardial infarction. Mortality at 30 days was significantly lower in the REST group (19% vs 38%; P .03), as was overall in-hospital mortality (22% vs 46%; P .003). Transfusion restriction appears to be safe and resulted in fewer transfusions among this group of burn patients. Prospective studies are needed before broadly recommending a transfusion trigger of 7.0 g/dl. (J Burn Care Res 2006;27:826–834)Anemia frequently develops in thermally injured nephrine tumescence and tourniquets have signifi-patients who have sustained burns to more than cantly reduced operative blood loss,9,10 the fact10% TBSA.1–3 Postburn anemia has a wide variety remains that 100 ml to 250 ml of blood (or 2% toof causes. First, acute erythrocyte destruction from 5% of the circulating blood volume) are shed forthermal and inflammatory insults, combined with every 1% BSA that is excised and grafted.9,11 Fi-sequestration of erythrocytes within the throm- nally, burn patients, especially those that are criti-bosed microcirculation of the burn wound,4 – 6 re- cally ill, are repetitively phlebotomized for labora-sults in a loss of up to 18% of erythrocytes within 24 tory studies and monitoring. Although the amounthours of a 15% to 40% TBSA full-thickness burn.2 of blood drawn from burn patients has not beenSecond, despite supranormal erythropoietin levels, specifically studied, a recent prospective observa-the marrow response to erythropoietin appears to tional study of more than 1000 critically ill patientsbe suppressed after burn injury, resulting in slug- in the intensive care unit found that a mean of 41gish erythrocyte production.7,8 Third, burn pa- ml of blood was drawn in a 24-hour period purelytients are subjected to regular blood loss as they for laboratory investigations.12 It would be reason-undergo staged excisions of the burn wound and able to assume that critically ill burn patients lose atharvesting of skin grafts. Although the use of epi- least this much blood on a daily basis, solely for diagnostic purposes. Consequently, patients with significant burns willFrom the The Ross Tilley Burn Centre, Sunnybrook and Women’s College Health Sciences Centre, Toronto, Canada. likely develop anemia, which almost certainly will beAddress correspondence to Dr. R. Cartotto, Room D710, Ross treated with one or more blood transfusions. Histor- Tilley Burn Centre, Sunnybrook Health Sciences Centre, 2075 ically, the decision as to when to transfuse a patient Bayview Avenue, Toronto, Ontario, Canada M4N 3M5.Copyright © 2006 by the American Burn Association. was largely based on an arbitrary hemoglobin or he-1559-047X/2006 matocrit level (or “trigger”), and was based to a lesserDOI: 10.1097/01.BCR.0000245494.45125.3E extent on the presence of a clinical hemodynamic826
  2. 2. Journal of Burn Care & ResearchVolume 27, Number 6 Kwan, Gomez, and Cartotto 827indication, such as myocardial ischemia or acute were identified using our burn center’s computerizedblood loss during surgery. The “classic” trigger for database. Charts of eligible subjects were then re-many years was a hemoglobin level less than 10 g/dl trieved from the hospital’s health data records ser-or a hematocrit less than 30%. Recently, Palmieri vices. Transfusion records were retrieved from theet al13,14 conducted multicenter surveys of North hospital blood services laboratory patient database.American burn centers and found that burn physi- Patients with %TBSA burns 20% or greater who sur-cians reported a mean transfusion threshold of 8.1 vived at least 24 hours were eligible for inclusion ing/dl.13 However, on closer examination of data from the study. Exclusion criteria included age younger666 patients with burns 20% TBSA or greater,14 the than 16 years, presence of associated trauma, knownhemoglobin levels at first and last transfusions were diagnosis of chronic anemia at admission (hemoglo-9.4 g/dl and 9.1 d/l, respectively, suggesting a trans- bin 13.5 g/dl in male patients, 12.0 g/dl in fe-fusion trigger higher than 9 g/dl. male patients), missing or incomplete records, and a These transfusion triggers for burn patients are patient’s declaration of personal or religious reasonhigher and at odds with transfusion thresholds now for refusing blood transfusions.recommended for other critically ill patients. TheTransfusion Requirements in Critical Care (TRICC) Study GroupsTrial15 prospectively randomized 838 patients in the Eligible subjects were assigned to one of two studyintensive care unit (ICU) to either a restrictive trans- groups based on our adoption of a transfusion triggerfusion strategy using a trigger of 7 g/dl with a goal of 7.0 g/dl in 1999, following publication of thehemoglobin level of 7 to 9 g/dl or to a liberal trans- TRICC Trial.15 Patients treated in the 2 years beforefusion strategy using a trigger of 10 g/dl with a goal 1999, during which time we were not using a trans-hemoglobin level of 10 to 12 g/dl. Patients in the fusion trigger of 7.0 g/dl (ie, from January 1, 1997,restricted transfusion group received less blood, ex- to December 31, 1998) formed the liberal transfu-perienced slightly less organ dysfunction, and had sion group (LIB). Patients treated after adoption ofcomparable mortality with those in the liberal group, the 7.0 g/dl transfusion threshold (ie, from April 1,indicating that the restrictive strategy was at least as 1999, to May 3, 2004), were assigned to the restric-effective as the liberal strategy. tive transfusion group (REST). A 2-year period was The appropriate transfusion trigger for a burn pa- selected for the LIB group because significant changestient is not known. In 1999, after the publication of in patient care took place in 1996 with the appointmentthe TRICC trial, we adopted a transfusion trigger of of a new burn director in our unit at that time. Because7 g/dl for patients in our burn center. This decision we wished to avoid the confounding influence ofwas done empirically, although there was some lim- changes in practice patterns that took place in 1996, weited evidence from two small studies to suggest that selected only the 1997 to 1998 period for the LIBtransfusion thresholds significantly lower than the 10 group.g/dl or 30% hematocrit level were well tolerated byburn patients.16,17 The purpose of the present study Data Collectionwas to evaluate the effects of implementing a restric- Data were collected and analyzed during the first 30tive transfusion strategy with a transfusion trigger of days post burn or until discharge or death if either7.0 g/dl among adult burn patients treated at our occurred before 30 days after injury. Admission datafacility. Specifically, we were interested in whether included age, etiology of burn, %TBSA burns,the intended transfusion threshold was achieved, APACHE II score, and presence of inhalation injurywhether less blood was transfused, and whether the diagnosed by bronchoscopic examination.18 Physio-restrictive approach affected outcomes such as organ logic variables were obtained daily and included thefunction, length of stay, duration of mechanical ven- PaO2/FiO2 ratio, serum creatinine concentration,tilation, and survival. serum bilirubin concentration, and the platelet count. If the variable had been measured more than once on a given day, the value closest to 8 AM on that day wasMETHODS recorded. Data pertaining to anemia and transfusion included the daily hemoglobin concentration (again,Study Design, Inclusion, and if more than one determination, the value closest to 8Exclusion Criteria AM was selected), the number of diagnostic bloodThis study was an Ethics Review Board-approved, draws per day, the number of units of blood trans-retrospective chart review by one researcher at an fused daily in all settings (burn unit and operatingadult regional burn center. Eligible study patients room), and the hemoglobin concentration before
  3. 3. Journal of Burn Care & Research828 Kwan, Gomez, and Cartotto November/December 2006transfusion of blood. If a transfusion involved more imum (worst) score of 24 as a means of adjusting thethan 1 unit of blood, the hemoglobin before the first measured organ dysfunction for death (“the adjustedunit was recorded as representative of all units given MOD score”). The Delta Multiple Organ Dysfunc-at that transfusion, unless the hemoglobin concentra- tion score ( MOD score) is the difference betweention was specifically measured between units, in the MOD score on admission and the overall worstwhich case this value also was recorded for the re- MOD score during hospitalization, and was used tomaining units that were administered at that transfu- measure the change in organ dysfunction over time.sion. For blood transfused in the operating room, The presence of sepsis, as defined by the ACCP/the preoperative hemoglobin concentration was re- SCCM Consensus Criteria20 (ie, 2 or more positivecorded as the pretransfusion hemoglobin, unless the SIRS signs: temperature 36°C or 38°C, heart ratehemoglobin was measured intraoperatively, in which 90 beats/min, white blood cell count 4000/mm3case this value also was recorded as a hemoglobin or 11,000/mm3, and respiratory rate 20 breaths/before transfusion. min or PaCO2 32 mm Hg and the presence of a documented infection), was assessed daily over the en-Transfusion Protocol tire hospital stay for each patient.Because this study was not prospective, patients werenot subjected to a rigid transfusion protocol. In the Statistical AnalysisLIB group, which was treated before 1999, blood was All values are reported as the mean SD unless oth-transfused at an undefined hemoglobin threshold. In erwise stated. The means of continuous variables be-the REST group, which was treated after 1999, a trans- tween groups were compared using a two-tailed Stu-fusion threshold of 7 g/dl was adopted by the physi- dent’s t-test, whereas categorical variables werecians in our burn center. This threshold was not rigidly compared with the 2 test. A P value .05 was con-enforced but was progressively adopted on an empiric sidered statistically significant.basis after publication of the TRICC trial.15 Single ormultiple unit transfusions were allowed, but, unlikethe TRICC trial, hemoglobin concentrations were RESULTSnot measured before and after each and every unit ofblood transfused. Our blood bank supplies units of Study Populationsblood, which range in volume between 240 and 340 Between January 1 1997 and December 1998, thereml, with a hematocrit of approximately 80%. Begin- were 59 patients who were potentially eligible forning in April of 1999, all blood supplied to our facility inclusion in the LIB group. Of these, 6 were excludedby the Canadian Blood Service was in the form of as a result of death within 24 hours of injury, and 16leuko-reduced packed red blood cells. were excluded because of missing or incomplete records. This left 37 subjects who formed the LIBOutcome Measures group. Between April 1, 1999, and May 3, 2004,Outcome measures included mortality from all causes there were 143 patients who potentially were eligibleat 30 days, the in-hospital mortality rate, hospital for inclusion in the REST group. Of these, five werelength of stay, and the duration of mechanical venti- excluded because of death within 24 hours of injury,lation. The duration of mechanical ventilation was two were excluded because of presence of associateddefined as the time from intubation to the time where polytrauma, and one was excluded because of missingthere had been 48 consecutive hours without any records. This left 135 patients who formed the RESTmechanical ventilation support, not including oxygen group. The baseline characteristics of the two groupsadministration by face mask, tracheostomy mask, or are shown in Table 1. There were no significant differ-nasal prongs. ences between the groups with respect to age, total or Organ dysfunction was measured by the raw values full-thickness burn size, presence of inhalation injury,of the PaO2/FiO2 ratio (respiratory system), serum APACHE II score, timing of first wound excision, orcreatinine concentration (renal system), serum biliru- total number of operative procedures (Table 1).bin concentration (hepatic system), and the plateletcount (hematologic system). The Multiple Organ Anemia and TransfusionDysfunction Score, defined by Marshall et al,19 as- The mean daily hemoglobin level over the first 30signs a score of 0 (best) to 4 (worst) to each of 6 organ days after burn was 10.2 2.3 g/dl in the LIB groupsystems (Appendix 1). A daily MOD score was deter- and 8.6 2.2 g/dl in the REST group (P .001).mined for each patient as described by Marshall et Also, the mean hemoglobin concentration was signif-al,19 and then patients who died were assigned a max- icantly lower in the REST group on each day after the
  4. 4. Journal of Burn Care & ResearchVolume 27, Number 6 Kwan, Gomez, and Cartotto 829Table 1. Baseline comparison of the liberal transfusion group (LIB) and the restrictive transfusion group (REST) withrespect to patient age, %TBSA burns, %TBSA full-thickness burns, admission APACHE II score, postburn day of the firstburn wound excision, and total number of operations performed in the first 30 days after burn LIB REST P ValueN 37 135Age SD, years 42 16 42 17 .914%TBSA burn SD 38 17 37 14 .899%TBSA full thickness SD 19 18 15 18 .323Admission APACHE II SD 14 9 16 8 .219Inhalation injury 13/37 (35%) 35/135 (26%) .211Day first wound excision 4.4 3.6 4.4 4.4 .936Total trips to operating room per 30 days 2.6 2.6 3.2 2.3 .15fourth day after burn injury (P .01; Figure 1). The REST group (P .539). Within each group, signif-pretransfusion hemoglobin (ie, the “transfusion trig- icantly more blood was transfused in the burn unit asger”) was 9.2 2.1 g/dl in the LIB group and 7.1 compared with in the operating room (LIB group:1.0 in the REST group (P .001). The %TBSA burn 6.3 7.5 units vs 3.1 4.3 units, respectively, Pdid not affect the transfusion threshold in the REST .03; REST group: 7.1 7.4 units vs 1.6 2.9 units,group. Patients with 40% or greater TBSA (n 51) respectively, P .001). The difference between thehad a pretransfusion hemoglobin of 7.0 10.0 g/dl, LIB and REST groups in the number of burn unitwhereas those with burns less than 40% TBSA (n transfusions was not significant (P .583), but there84) had a pretransfusion hemoglobin of 7.1 10.3 were significantly fewer operating room transfusionsg/dl (P .350). Conversely, patient age did influ- in the REST group (P .02). A post-hoc subgroupence the pre-transfusion hemoglobin threshold in the analysis was performed in the REST group to exam-REST Group: 7.4 8.7 g/dl in patients older than ine only patients who always had a pretransfusion60 years of age (n 23) vs. 6.9 10.0 in patients hemoglobin less than 7.5 g/dl (ie, those that mostyounger than 60 years of age (n 112; P .001). closely followed the restrictive strategy). There were The mean daily transfusion rate over the first 30 80 patients who always met the criteria of a pretrans-days after burn was significantly greater in the LIB fusion hemoglobin less than 7.5 g/dl. This subgroupgroup than in the REST group (0.6 0.6 units/ received a mean of 3.9 5.6 units of blood over thepatient/day vs 0.4 0.4 units/patient/day, P first 30 days after burn, which was significantly lower.03). The postburn day of the first transfusion was 4.9 than the patients in the LIB group (n 37), who2.8 days in the LIB group and 5.3 3.1 days in the received 6.3 7.3 units of blood in the first 30 daysFigure 1. Mean SD daily hemoglobin concentration over the first 30 days after burn in the restrictive group (closed triangles)and the liberal group (closed circles). The mean daily hemoglobin concentration is significantly lower on all days in therestrictive group after postburn day 4 (P .01).
  5. 5. Journal of Burn Care & Research830 Kwan, Gomez, and Cartotto November/December 2006 units transfused to patients in the REST group was 18 8 days. Outcomes The 30-day mortality rate was 38% in the LIB group and 19% in the REST group (P .03). Overall in-hospital mortality also was significantly greater in the LIB group than in the REST group (46% vs 22 %, P .003). The daily % survival rates in each group over the first 30 days after burn are shown in Figure 2. Comparison of demo-Figure 2. Plot of the percent survival on each day post burn graphic data between survivors and nonsurvivors in eachin the restrictive group (closed triangles) and the liberal group is provided in Table (closed circles). The adjusted MOD score was significantly higher (worse) in the LIB Group than in the REST Group (7.9 2.5 vs 6.4 1.0, respectively, P .004),(P .05). Finally, among those patients who had no (Figure 3). However, the MOD score, where atransfusions during the first 30 days after burn, the higher value represents a greater deterioration in or-LIB group had significantly fewer transfusion-free gan function over time, did not differ significantlydays than the REST group: in the LIB group, 8 of 37 between the LIB and REST groups (3.5 3.3 vspatients (22%) received no blood whatsoever over 3.7 2.9, respectively, P .614). It was observed12.6 6.9 days while alive and in hospital, whereas in that despite a 3-fold difference in sample size betweenthe REST group, 35 of 135 patients (26%) received the LIB and REST groups, there was a 6-fold differ-no blood whatsoever over 19.6 8.3 days while alive ence in the number of laboratory measures of vari-and in-hospital (P .03). ables used to determine the MOD score (PaO2/FiO2 ratio, creatinine, platelet count, bilirubin), with 1372Single vs Multiple Unit Transfusions, measures in the LIB group vs 8000 measures in theAge of Blood REST group. In the LIB group, there were 5.3 8.6In the LIB group, 18% of all transfusions were single- separate episodes of consensus criteria defined sepsisunit transfusions, whereas 82% were multiple unit over the entire hospital stay, compared to 4.7 5.4( 2 unit) transfusions. The mean number of units episodes in the REST group (P .624).transfused at a multiunit transfusion was 2.2 0.4 The incidence of mechanical ventilation was 51% inunits. In the REST group, 34% of transfusions were the LIB group and was 74% in the REST group (Psingle unit, and 66% were multiple-unit transfusions. .004). The duration of mechanical ventilation wasThe mean number of units transfused at a multiple- 14 11 days in the LIB group and 20 18 days inunit transfusion in the REST group was 2.1 0.2 the REST group (P .151). Overall hospital lengthunits. The difference in proportion of single vs multiple- of stay was not significantly different between the LIBunit transfusions between the LIB and REST groups and REST groups (45 88 days vs 44 38 days,was statistically significant (P .01). Data for the respectively, P .942). The incidence of acute myo-stored age of blood units transfused in the LIB group cardial infarction over the entire hospital stay was 2.7%were not available, but the mean storage age of all in the LIB group and 2.9 % in the REST group.Table 2. Comparison of mean SD age, %TBSA, %BSA full thickness burn (%BSA full), and incidence of smoke inhalationinjury in survivors and nonsurvivors in the liberal transfusion group (LIB) and the restrictive transfusion group (REST) LIB Group REST Group Survivors Nonsurvivors Survivors NonsurvivorsAge, years 37 12 49 17 40 15 50 18%TBSA burn 37 10 44 20 36 14 45 16%BSA full 11 13 27 18 12 16 26 21Inhalation injury 5/20 (25%) 8/17 (47%) 22/105 (21%) 13/30 (43%)
  6. 6. Journal of Burn Care & ResearchVolume 27, Number 6 Kwan, Gomez, and Cartotto 831Figure 3. Graph showing the daily adjusted Multiple Organ Dysfunction score in the restrictive group (closed Triangles) andthe liberal group (closed circles).DISCUSSION tration of 8.6 1.7 g/dl, suggesting that although transfusion triggers in the critically ill are lower thanIn 1999, after the publication of the TRICC trial,15 the historical level of 10 g/dl, they have not beenwhich recommended a transfusion threshold of 7.0 uniformly or consistently reduced to the level of 7.0g/dl for critically ill patients in the intensive care unit, g/dl identified in the TRICC trial. This alone is anwe empirically adopted a transfusion trigger of 7.0 interesting observation on the relative success or fail-g/dl in our adult regional burn center. The results of ure of adopting evidence based guidelines in clinicalthe present study indicate that among adult burn pa- practice. Furthermore, the significant reduction in in-tients with burns 20% or greater TBSA, we success- cidence of multiple-unit transfusions from 82% in thefully achieved a transfusion trigger very close to 7.0 LIB group to 66% in the REST group is further evi-g/dl and that over the first 30 days after burn, this dence of a profound shift in our clinical approach toresulted in a significantly lower daily hemoglobin transfusion of blood.concentration and significantly less transfusion ofblood than in the 2-year period before 1999, during The appropriate transfusion trigger for a burn pa-which we did not use a 7.0 g/dl trigger. Further- tient is not known. The recent multicenter study ofmore, burn patients treated during the period when transfusion among 666 patients with 20% or greaterwe used a restrictive transfusion protocol demon- TBSA treated in North American Burn Centers re-strated less organ dysfunction and improved survival vealed that the mean hemoglobin concentrations be-compared with their counterparts who were treated fore the first and last transfusions were 9.4 g/dl andwith a more liberal transfusion approach. 9.1 g/dl, respectively. Two small studies in burn pa- We were encouraged to find that the transfusion tients have evaluated the use of lower transfusiontrigger of 7.0 g/dl was successfully implemented de- thresholds than these. Sittig and Deitch16 prospec-spite the absence of a rigid protocol. This finding is in tively compared a restrictive approach to transfusioncontrast to results obtained from two very large pro- (transfusion for hemoglobin 6.0 g/dl) in 14 pa-spective multicenter studies on transfusion in the crit- tients (mean of 28% TBSA burns), with a historicalically ill that were published subsequent to the control group of 38 patients (mean of 26% TBSATRICC trial. In the Anemia and Blood Transfusion in burns), where a liberal transfusion strategy was ap-Critically Ill Patients (ABC) Ttrial,12 3534 patients in plied (hemoglobin maintained 10 g/dl). The re-Western Europe were transfused for a mean ( SD) strictive strategy significantly reduced blood transfu-pretransfusion hemoglobin concentration of 8.5 sions and did not cause any apparent adverse clinical1.1 g/dl. In the CRIT study,21 4892 critically ill pa- effects. In a retrospective study by Mann et al,17 41tients in the United States were transfused blood for patients with burns greater than 10% TBSA treated inat a mean ( SD) pretransfusion hemoglobin concen- 1980 were compared with 38 patients with burns
  7. 7. Journal of Burn Care & Research832 Kwan, Gomez, and Cartotto November/December 2006greater than 10% TBSA treated in 1990. There was a ever, we felt that any clinically relevant change in thesignificant reduction in blood transfused between the variable would have persisted for more than 24 hoursearlier and later time periods. Although transfusion and would have been captured at the next 8 AM re-thresholds were not reported in that study, the au- cording. It should also be noted that this approachthors suggested that the reduction in transfusion was has been used in other well validated studies such aspartially related to a reduction in the hematocrit that used to develop the MOD score, by Marshall ettransfusion threshold from 30% in the earlier period al.19 Also, the REST group had a disproportionatelyto 15% to 20% in the later period. Although both of greater number of laboratory values measured relativethese studies are limited by small size and their retro- to the LIB group. Although we cannot specificallyspective design, they provide an important first step in explain the reason for this, it is possible that patientsconsidering the concept of restricted transfusion in the REST group were being more closely moni-strategies in burn patients. tored, which may have contributed to the improved The results of our study would suggest that for outcomes seen in this group. Also, fewer operatingburn patients with burns 20% TBSA, a restrictive room transfusions were given in the REST grouptransfusion approach using a trigger of 7.0 g/dl is safe than in the LIB group. Therefore, some of the ob-and at least as effective as the previous trigger of 9.2 served reduced transfusion requirements in the RESTg/dl, which we used before 1999. It is essential to group may simply have been from less surgical bloodemphasize, however, that this approach must be loss. However, because intraoperative transfusion intested in a randomized prospective fashion because of our institution is based on measured hemoglobin lev-the limitations inherent in a retrospective analysis els rather than on empiric grounds and because theresuch as this. In particular, the use of a historical con- were no major changes in surgical technique (eg, usetrol group, with a relatively limited number of sub- of tumescence and tourniquets) between the LIB andjects and where several cases were excluded because of REST groups, we believe this is a relatively minormissing records, are all important potential sources of consideration.error. In particular, the small sample size in the LIB We cannot rule out the contributory effects ofgroup may have been partly to blame for the relatively changes in ICU care that have taken place duringthehigh reported mortality rate in this group. Another 7-year span of this study. The difference in the inci-important consideration in the present study is that dence of mechanical ventilation, for example, mightHb was not measured before and after each and every suggest that the REST group was being managedunit of blood transfused, as was done in the TRICC more aggressively. Also, although there were no spe-trial.15 Thus, the transfusion threshold may actually cific changes in protocol over the study period, therehave been greater than that reported because some have been evolving trends in critical care such as use ofunits of blood could have been transfused at a higher lung protective ventilation, and more restricted se-(but unidentified) threshold. We would expect this rum glucose control, that may well have contributedundermeasurement of the transfusion threshold to to the reported differences in outcomes. Finally,have been more profound in the LIB group since the blood transfused after 1999 (ie, that given to patientsvast majority of transfusions in that group (82%) in- in the REST group) was leukoreduced, and it is con-volved two or more units of blood, whereas in the ceivable that this also played a role in the better out-later REST group, we would expect less of an under- come seen in the REST group.measurement of threshold because a significantly lower The much-anticipated randomized prospective studyproportion of transfusions (66%) were multiple-unit of restrictive vs liberal approaches to transfusion in burntransfusions. However, the mean number of units patients, currently being organized through the Burntransfused at a multiple-unit transfusion in both Multi-Center Trials Group of the American Burn As-groups was just more than 2 units per transfusion, so sociation, will address the limitations in our study andit seems unlikely that recording of Hb before each will likely provide more definitive guidelines on trans-and every unit of blood would have produced sub- fusion thresholds for burn patients. However, we be-stantially different results. lieve that the findings of this study support the notion Another limitation in this study was that we col- that a more restrictive approach to transfusion is safelected data closest to 8 AM hours when more than one and well tolerated among adult burn patients.recorded variable was recorded in a 24-hour period. The question of whether a higher transfusionWe did this to be as consistent and standardized as threshold should be used in an elderly burn patient orpossible, but the potential downside of this approach in a burn patient with a known history of coronaryis that we may have not captured deterioration or artery disease has not been answered by this study. Ofimprovement in a variable in some patients. How- interest was that our transfusion threshold was signif-
  8. 8. Journal of Burn Care & ResearchVolume 27, Number 6 Kwan, Gomez, and Cartotto 833icantly higher in patients older than 60 years of age hours after injury was an independent predictor ofcompared to those younger than age 60, despite the MOF and that there was a dose-response relationshipfact that we did not predefine any specific adjustments between early blood transfusion and the severity offor patient age to our restrictive strategy. Interest- later MOF. Thus, transfusion of blood appears to beingly, in the TRICC trial,15 neither age older than 55 harmful in many respects and, therefore, the restric-years nor the presence of cardiac disease had any effect tion of transfusion would be expected to be associ-on mortality in patients treated with a restrictive ated with improved outcomes. The results of thetransfusion strategy. present study support this concept. Although we can- Blood transfusion is not a benign therapy. The use not directly relate the improved survival and reducedof blood products, specifically whole blood and organ dysfunction to the lower transfusion rate in thepacked red blood cells, introduces a variety of risks REST group, our results indicate that a restrictedand morbidities. Risks include transfusion reactions, transfusion policy is at least as safe and effective as atransfusion related bacterial sepsis, and infectious dis- liberal approach to transfusion. The improvements inease transmission from donor to recipient.22–24 The outcome may well have been related to other im-morbidity associated with blood transfusion mainly provements in treatment and accumulation of expe-revolves around immunosuppressive effects on the rience that occurred over the seven year span of thisrecipient.25–29 Studies in animal burn models and hu- study. Nevertheless, the 7.0 g/dl transfusion thresh-mans with burns demonstrate that blood transfusion old identified in the present study provides an impor-depresses immune function and increases the risks of tant preliminary step which must now be more care-infectious complications.30 –34 There was a statisti- fully scrutinized in a prospective randomized study incally insignificant trend toward fewer episodes ofsepsis in the REST group, which may reflect less burn patients.transfusion-related immunosuppression with the re-strictive transfusion strategy. The development oftransfusion-related acute lung injury, defined clini- CONCLUSIONcally as a syndrome of acute lung injury that developsduring or within 6 hours of transfusion, is also an In this study, a restrictive transfusion strategy resultedemerging potential risk now recognized to be associ- in significant decreases in the number of blood trans-ated with transfusion.35 The potential adverse effects fusions given to burn patients accompanied by a sig-associated with blood transfusion have been demon- nificant decrease in 30-day and overall mortality. Thestrated in both the ABC trial12 and the CRIT study21 use of a restrictive transfusion strategy for burn pa-which, when combined, involved more than 8000 tients is recommended. Although the results of thisICU patients. In both of these studies, the amount of study support the use of restrictive blood transfusiontransfused blood was independently associated with strategies in burn patients, a large-scale randomizedincreased mortality. Similarly, among trauma pa- controlled trial is needed to definitively study thetients, blood transfusion increases the risk of subse- problem. The resulting outcomes could help deter-quent multiorgan failure (MOF). In a study of 513 mine whether a restrictive strategy is truly beneficialconsecutive trauma patients, Moore et al36 demon- for burn patients, and potentially which subgroups ofstrated that blood transfusion during the first 12 burn patients would most benefit.Appendix 1. The Multiple Organ Dysfunction Score19 SCORE 0 1 2 3 4PaO2/FiO2 300 226–300 151–225 76–150 75Creatinine ( mol/l) 100 101–200 201–350 351–500 500Bilirubin ( mol/l) 20 21–60 61–120 121–240 240Pulse-adjusted heart rate (PAR) 10 10.1–15.0 15.1–20 20.1–30 30 (heart rate central venous pressure/mean arterial pressure)Platelets/ml, 10–3 120 81–120 51–80 21–50 20Glasgow Coma Scale 15 13–14 10–12 7–9 6
  9. 9. Journal of Burn Care & Research834 Kwan, Gomez, and Cartotto November/December 2006REFERENCES 20. Bone RC, Balk RA, Cerra FB. American College of Chest Physicians/Society of Critical Care Medicine Consensus 1. Shankar R, Amin CS, Gamelli RL. Hematologic, hematopoi- Conference: Definitions for sepsis and organ failure and etic, and acute phase response. In: Herndon DN, editor. guidelines for the use of innovative therapies in sepsis. Chest Total burn care. London: Saunders Co.; 2002. p. 331–2. 1992;101:1644–55. 2. Topley E, Jackson DM, Cason JS, Davies JWL. Assessment of 21. Corwin HL, Gettinger A, Pearl R, et al. The CRIT study: Red Cell Loss in the First Two Days After Severe Burns. Ann anemia and blood transfusion in the critically ill– current clin- Surg 1962;155:581–90. ical practice in the United States. Crit Care Med 2004;32: 3. Loebl EC, Baxter CR, Curreri PW. Erythrocyte survival fol- 39–52. lowing thermal injury J Surg Res 1974;16:96–101. 22. Pomper GJ, Wu Y, EL, Snyder, et al. Risks of transfusion- 4. Robb HJ. Dynamics of the microcirculation during a burn. transmitted infections: 2003. Curr Opin Hematol 2003;10: Arch Surg 1967;94:776–80. 5. Kimber RJ, Lander H. The effect of heat on human red cell 412–8. morphology, fragility, and subsequent survival in vivo. J Lab 23. Kleinman S, Chan P, Robillard P. Risks associated with trans- Clin Med 1964;64:922–3. fusion of cellular blood components in Canada. Trans Med 6. Heatherill RJ, Till GO, Burner LH, Ward PA. Thermal in- Rev 2003;17:120–62. jury, intravascular hemolysis, and toxic oxygen products. 24. Reading FC, Brecher ME. Transfusion-related bacterial sep- J Clin Invest 1986;78:629–36. sis. Curr Opin Hematol 2001; 8:380–6. 7. Deitch EA, Sittig KM. A serial study of the erythropoeitic 25. Chang H, Hall GA, Geerts WH, et al. Allogeneic red blood response to thermal injury. Ann Surg 1993;217:293–9. cell transfusion is an independent risk factor for the develop- 8. Andes WA, Rogers PW, Beason JW, Pruitt BA. The erythro- ment of postoperative bacterial infection. Vox Sanguinis poietin response to the anemia of thermal injury. J. Lab Clin 2000;78:13–8. Med 1976;88:584–92. 26. Triulzi DJ, Blumberg N, Heal JM. Association of transfusion 9. Cartotto R, Musgrave MA, Beveridge M, Fish J, Gomez M. with postoperative bacterial infection. Crit Rev Clin Lab Sci Minimizing blood loss in burn surgery. J Trauma 2000;49: 1990;28:95–107. 1034–9. 27. Kendall SJ, Weir J, Aspinall R, et al. Erythrocyte transfusion10. Sheridan RL, Szyfelbein SK. Trends in blood conservation in causes immunosuppression after total hip replacement. Clin burn care. Burns 2001;27:272–6. Orthop Rel Res 2000 381:145–55.11. Budney PG, Regan PJ, Roberts AHN. The estimation of 28. Salinas JC, Cabezali R, Torcal J, et al. Immune response and blood loss during burns surgery. Burns 1993;19:134–7. cytokines in septic rats undergoing blood transfusion. J Surg12. Vincent JL, Baron JF, Reinhart K, et al. Anemia and blood Res 1998;80:295–9. transfusion in critically ill patients. JAMA 2002;288: 29. Waymack JP, Alexander JW. Blood transfusions as an immu- 1499–507. nomodulator—a review. Comp Immunol Microbiol Infect13. Palmieri TL, Greenhalgh DG. Blood transfusion in burns: Dis 1986; 9: 177–83. what do we do? J Burn Care and Rehabilitation 2004;25: 30. Waymack JP, Rapien J, Garnett D, et al. Effect of transfusion 71–5. on immune function in a traumatized animal model. Arch14. Palmieri TL, Caruso DM, Foster KN, et al. Blood transfusion Surg 1986;121:50–5. practices in major burns: a multicenter study. J Burn Care 31. Waymack JP, Robb E, Alexander JW. Effect of transfusion on Rehabil 2004;25:S47(abstract). immune function in a traumatized animal model. II. Effect on15. Hebert PC, Wells G, Blajchman MA, et al. A multicenter, mortality rate following septic challenge. Arch Surg 1987; randomized, controlled clinical trial of transfusion require- 122:935–9. ments in critical care. Transfusion Requirements in Critical 32. Winslow GA, Shelby J, Nelson EW, et al. Influence of allo- Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999;340:409–17. geneic blood transfusion on natural killer cell activity in burn-16. Sittig KM, Deitch EA. Blood transfusions: for the thermally injured mice. J Burn Care Rehabil 1996;17:117–23. injured or for the doctor? J Trauma 1994;36:369–72. 33. Waymack JP, Gallon L, Barcelli U, et al. Effect of blood17. Mann R, Heimbach DM, Engrav LH, Foy H. Changes in transfusions on macrophage function in a burned animal transfusion practices in burn patients. J Trauma 1994;37: model. Curr Surg 1986;43:305–7. 220–2. 34. Gianotti L, Pyles T, Alexander JW, et al. Impact of blood18. Fitzpatrick JC, Cioffi WG. Diagnosis and treatment of inha- transfusion and burn injury on microbial translocation and lation injury. In: Herndon DN, editor. Total burn care. bacterial survival. Transfusion, 1992;32:312–7. London: Saunders Co.; 2002. p. 232–41. 35. Toy P, Gajic O. Transfusion related acute lung injury. Anesth19. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung C, Analg 2004;99:1623–4. Sibbald WJ. The multiple organ dysfunction score: a reliable 36. Moore FA, Moore EE, Sauaia A. Blood transfusion: an inde- descriptor of a complex clinical outcome. Crit Care Med pendent risk factor for postinjury multiple organ failure. Arch 1995;23:1638–52. Surg 1997;132:620–4.