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  1. 1. How Key Enzyme Repairs Sun-Damaged DNAandDNA Discovery Opens New Door to Develop Tools, Therapies for Hereditary Cancers<br />Andrés Felipe Maya Osorno<br />UPB Faculty of Medicine<br />3th semester<br />2010<br />
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  4. 4. INTRODUCTION<br />the photolyase is an enzyme that protects against damage from sunlight.<br />the photolyase is not in ranging mammals<br />The MutL protein is one that is responsible for repairing damage caused by the sun<br />
  5. 5. How Key Enzyme Repairs Sun-Damaged DNA<br />
  6. 6. How Key Enzyme Repairs Sun-Damaged DNA<br />↓<br /><ul><li>The sun shines its light directly on the cell produces alterations
  7. 7. The cell has mechanisms to repair the damage caused</li></li></ul><li>How Key Enzyme Repairs Sun-Damaged DNA<br />The photolyase is an enzyme found in diverse organisms can protect them from such harm, the human enzyme does not have this.<br />photolyase breaks up those errant bonds in just the right spots to cause the atoms in the DNA to move back into their original positions<br />
  8. 8. How Key Enzyme Repairs Sun-Damaged DNA<br />Humans do possess some enzymes that can undo damage with less efficiency<br />when these enzymes are not capable of repairing the damage are sunburn and DNA mutations<br />
  9. 9. Demonstrations when the sun causes DNA damage<br />
  10. 10. Student opinion<br />
  11. 11. DNA Discovery Opens New Door to Develop Tools, Therapies for Hereditary Cancers<br />
  12. 12. DNA Discovery Opens New Door to Develop Tools, Therapies for Hereditary Cancers<br />Although humans do not have photolyase, the cells have a variety of DNA repair systems to correct these errors or cell death when the damage can not be fixed.<br />The protein is MutL<br />
  13. 13. DNA Discovery Opens New Door to Develop Tools, Therapies for Hereditary Cancers<br />MutL becomes an enzyme that cuts DNA error. PCNA also discovered that another protein inside the track, allowing the DNA that bind MutL so it can be repaired. the mystery is solved after 40 years that had PCNA function in DNA repair. <br />
  14. 14. Student opinion<br />
  15. 15. MEDICAL UTILITY <br />
  16. 16. How Key Enzyme Repairs Sun-Damaged DNA<br />The enzyme is not present in humans but may be using it for greater impact on those products as creams and lotions that prevent burns<br />
  17. 17. DNA Discovery Opens New Door to Develop Tools, Therapies for Hereditary Cancers<br />Inducers used to stimulate the MutL protein to generate apoptosis in those cells that already have damage and can not be repaire.<br />
  18. 18. How Key Enzyme Repairs Sun-Damaged DNAandDNA Discovery Opens New Door to Develop Tools, Therapies for Hereditary Cancers<br />Use both discoveries as a therapy for treating skin cancer by using vectors that may alter the DNA for both proteins<br />
  19. 19. BIBLIOGRAPHY <br />Monica C. Pillon, Jessica J. Lorenowicz, Graham C. Walker, Lyle A. Simmons, Peter Friedhoff, Alba Guarn. Structure of theEndonucleaseDomain of MutL: UnlicensedtoCut. Molecular Cell, July 9, 2010 <br />-Jiang Li, ZheyunLiu, Chuang Tan, XunminGuo, Lijuan Wang, AzizSancar & DongpingZhong. Dynamics and mechanism of repair of ultraviolet-induced (6%u20134) photoproductbyphotolyase. Nature, July 25, 2010 <br /> <br />

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