Personal Neuro Devices:      Medical applications of11/2/2012  mobile EEG           1
Electroencephalography (EEG)             Reads brain activity             Neurofeedback              therapy            ...
Mobile EEG             Not bound to lab             Links to smartphone             Makes EEG monitoring              a...
PND: mobile EEG software                      Mobile EEG beyond games                      Treatment, diagnostics, self-...
PND technologies: BackupBrain             Stores EEG info online             Accessible anywhere             Deeper ana...
PND technologies: Amygdala             Backend for non-game              mobile EEG software             Streamlines mob...
Proof-of-concept: Transcend Neurofeedback-based mobile meditation app Comprehensive meditation tracking & analysis Read...
Introspect EEG self-monitoring Records mental  states via EEG  waveform analysis
Introspect Detects: (e.g.)    Mood    Anxiety    Stress    Acute cognitive     functioning    Sleep quality         ...
Introspect             Detects problem areas             Built-in neurofeedback exercises to              improve specif...
Neurofeedback             Training to directly              alter EEG output             Mindfulness-based              ...
PND: Pharmaceutical uses Based on adaptations of Introspect Introspect malleable for    Research    Diagnostics    Tr...
PND: Pharmaceutical uses1) New drug testing mobile real-time drug efficacy monitoring E.g. observe mood in brain over time
PND: Pharmaceutical uses            2) Aid patient-specific            drug selection             EEG patterns linked to ...
PND: Pharmaceutical uses            3) Monitor patient progress             Ensure continued symptom              control...
PND: Pharmaceutical uses            4) Augment treatments             Raise overall efficacy             Neurofeedback11...
PND: Pharmaceutical uses            5) New class of as-            needed meds             Alarm for impending           ...
PND: Pharmaceutical uses6) Preventative medicine Catch “slipping” mental  health before disorder  develops
PND: Pharmaceutical uses            7) Diagnostics             Link day-to-day mental              states to disorders   ...
Thank you!Any questions?                 20
References•   MacDonald, P. E., Rorsman, P. (2006). Oscillations, intercellular coupling, and insulin secretion in pancrea...
References•   Caat, M. T., Lorist, M. M., Bezdan, E., Roerdink, J. B., & Mauritis, N. M. (2008). High-Density EEG Coherenc...
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Medical and pharmaceutical applications of mobile EEG (brain scanning)

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Uses of inexpensive, personal, commercially-available, and portable EEG devices for medical research. Testing of new drugs, patient-specific drug selection, monitoring of patient progress, augmentation of treatments (via neurofeedback), prediction of 'attacks' in mental illnesses (e.g. panic disorder), and better diagnoses of neurological disorders.

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  • gamification designers, graphic designersBased out of both san jose and ottawa, linked to Neurosky
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  • Medical and pharmaceutical applications of mobile EEG (brain scanning)

    1. 1. Personal Neuro Devices: Medical applications of11/2/2012 mobile EEG 1
    2. 2. Electroencephalography (EEG)  Reads brain activity  Neurofeedback therapy  Can track aspects of thought, emotion11/2/2012 2
    3. 3. Mobile EEG  Not bound to lab  Links to smartphone  Makes EEG monitoring available anywhere  Currently mostly for games11/2/2012 3
    4. 4. PND: mobile EEG software  Mobile EEG beyond games  Treatment, diagnostics, self- monitoring  Team  neuroscientists  software engineers  biomedical engineers  business development experts11/2/2012 4
    5. 5. PND technologies: BackupBrain  Stores EEG info online  Accessible anywhere  Deeper analysis11/2/2012 5
    6. 6. PND technologies: Amygdala  Backend for non-game mobile EEG software  Streamlines mobile EEG development  Algorithms, built-in GUIs, links to BackupBrain, etc.11/2/2012 6
    7. 7. Proof-of-concept: Transcend Neurofeedback-based mobile meditation app Comprehensive meditation tracking & analysis Reads relaxation, concentration, meditation  uses in-house algorithms
    8. 8. Introspect EEG self-monitoring Records mental states via EEG waveform analysis
    9. 9. Introspect Detects: (e.g.)  Mood  Anxiety  Stress  Acute cognitive functioning  Sleep quality Example waveforms linked to mental states  Concentration  Pain „unpleasantness‟
    10. 10. Introspect  Detects problem areas  Built-in neurofeedback exercises to improve specific areas PND neurofeedback game:11/2/2012 psych showdown 10
    11. 11. Neurofeedback  Training to directly alter EEG output  Mindfulness-based  Meditation  Effective treatment  ADHD  depression  Anxiety  etc.11/2/2012 11
    12. 12. PND: Pharmaceutical uses Based on adaptations of Introspect Introspect malleable for  Research  Diagnostics  Treatment  Etc.
    13. 13. PND: Pharmaceutical uses1) New drug testing mobile real-time drug efficacy monitoring E.g. observe mood in brain over time
    14. 14. PND: Pharmaceutical uses 2) Aid patient-specific drug selection  EEG patterns linked to disorder etiologies  Help hospital funding11/2/2012 14
    15. 15. PND: Pharmaceutical uses 3) Monitor patient progress  Ensure continued symptom control  Change treatments as needed Example mood and anxiety chart11/2/2012 15
    16. 16. PND: Pharmaceutical uses 4) Augment treatments  Raise overall efficacy  Neurofeedback11/2/2012 16
    17. 17. PND: Pharmaceutical uses 5) New class of as- needed meds  Alarm for impending “attack”  Preventative drug used upon alarm11/2/2012 17
    18. 18. PND: Pharmaceutical uses6) Preventative medicine Catch “slipping” mental health before disorder develops
    19. 19. PND: Pharmaceutical uses 7) Diagnostics  Link day-to-day mental states to disorders  Reduce reliance on self-report11/2/2012 19
    20. 20. Thank you!Any questions? 20
    21. 21. References• MacDonald, P. E., Rorsman, P. (2006). Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells. PLoS Biol, 4(2): p49.• Tatum, W. O., Husain, A. M., Benbadis, S. R. (2008). Handbook of EEG Interpretation. Demos Medical Publishing.• Niedermeyer E. and da Silva F.L. (2004). Electroencephalography: Basic Principles, Clinical Applications, and Related Fields. Lippincot Williams & Wilkins.• Rubboli, G., Parra, J., Seri, S., Takahashi, T., & Thomas, P. (2004). EEG diagnostic procedures and special investigations in the assessment of photosensitivity. Epilepsia, 45(s1), p35-39.• Appleton, R., Macleod ,S., Martland ,T. (2008). Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children. Cochrane Database of Systematic Reviews, 4: CD001905• Randell T. (2004). "Medical and legal considerations of brain death". Acta Anaesthesiologica Scandinavica 48 (2): 139– 144• Wijdicks EF. Determining brain death in adults. Neurology. 1995 May; 45(5): pp.1003-11• Kupfer, D. J., Foster, F. G., Coble, P., McPartland, R. J., and Ulrich, R. F. (1978). The application of EEG sleep for the differential diagnosis of affective disorders Am J Psychiatry 1978; 135:69-74• Otto, K. A. (2008). EEG power spectrum analysis for monitoring depth of anaesthesia during experimental surgery; Lab Anim , 42: pp. 45-61.• Sterman, M.B.; Friar, L. (1972). "Suppression of seizures in an epileptic following sensorimotor EEG feedback training". Electroencephalogr Clin Neurophysiol 33 (1): 89–95• Basic concepts and clinical findings in the treatment of seizure disorders with EEG operant conditioning". Clin Electroencephalogr 31 (1): 45–55.• Hammond, Corydon D. "Neurofeedback Treatment of Depression and Anxiety." Journal of Adult Development, Vol 12, Nos. 2/3, August 2005• Gastaut, H. (1952). "Etude electrocorticographique de al reactivite des rhytmes rolandiques". Rev. Neurol 87 (2): 176– 182• Sny-der et al. (2008). Blinded, multi-center val-i-da-tion of EEG and rat-ing scales in iden-ti-fy-ing ADHD within a clin-i-cal sam-ple. Psy-chi-a-try Research, 159, 346–358
    22. 22. References• Caat, M. T., Lorist, M. M., Bezdan, E., Roerdink, J. B., & Mauritis, N. M. (2008). High-Density EEG Coherence Analysis Using Functional Units Applied to Mental Fatigue. Journal of Neuroscience Methods, 17, pp. 271-278.• Nuwer, M,, et al, (2005). Routine and Quantitative EEG in Mild Traumatic Brain Injury; Clinical Neurophysiology, 116.• Thatcher, R.W., Camacho, M,, Salazar, A, Linden, C., Biver, C. and Clarke, L.: Quantitative MRI of Gray-White Matter Distribution in Traumatic Brain Injury. Journal of Neurotrauma, Volume 14, No. 1, 1-14, 1997• Thatcher, R.W., Moore, N, John, E.R., et al.: QEEG and Traumatic Brain Injury: Rebuttal of the American Academy of Neurology 1997. A Report by the EEG and Clinical Neuroscience Society, Clinical Electroencephalography, 30(3): 94-98, 1999• Khodayari-Rostamabad, A., Hasey, G. M., Maccrimmon, D. J., Reilly, J. P., & de Bruin, H. (2010). A pilot study to determine whether machine learning methodologies using pre-treatment electroencephalography can predict the symptomatic response to clozapine therapy. Clinical Neurophysiology, 121(12), 1998–2006• Baskaran, A., Milev, R., & McIntyre, R. S. (2012). The neurobiology of the EEG biomarker as a predictor of treatment response in depression. Neuropharmacology, 63(4), 507–13• Thompson, L. et al (2010). Neurofeedback outcomes in clients with Asperger’s syndrome. Applied psychophysiology and biofeedback, 35(1), 63–8• Kouijzer, M., et al. (2009). Neurofeedback Treatment for Autism Spectrum Disorders: Scientific Found- ations and Clinical Practice. Autism Spectrum Disorders – From Genes to Environment (p. 101–122) More available on request

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