Inflammation is associated with virtually all chronic, progressive diseases such as heart disease, vascular disease, asthma, IBS, autoimmune diseases, rheumatoid arthritis, osteoarthritis and even chronic neurological diseases such as Alzheimer’s disease. The signals that induce inflammation are multifactorial. High dose omega 3 has the potential to be as or more effective than pharmaceutical therapies. We will report on a series of omega 3 studies that compared dose response, dose timing, (e.g. once a day or twice a day), and food intake (with or without) in four separate cohorts.