Anwser,s    Dr :ANAS SAHLE   1. Chest xr cases. 2. Chest clinical case.   3. Chest ct cases.  4. Collicum exam.:http://www...
chest xr cases   Dr :anas sahle http://www.facebook.com/dranas224
CXR-26-a
CXR26-b
CXR26-c
CXR26-dDiagnosis for CXR26 is: Ankylosing Spondylitis                             Bamboo spine
CXR27Diagnosis is: Aneurysm Arch of Aorta
CXR28-a
CXR28-bOld film
CXR28:            Aneurysm Arch of Aorta                   Leaking Blood into Pleural Space• Mediastinal mass• Calcificati...
CXR29Diagnosis is: Pectus Excavatum
Pectus Excavatum• Indistinct right heart margin.• Vague density in right lower lung field• Lateral view• reveals protrudin...
CXR30-aDiagnosis is: Pulmonary Sequestration
CXR30-b  Aortogram
CXR30-cAortogram
Pulmonary Sequestration• Anomalous Arterialization of Lung:• Increased vascular markings at right base• Smaller right pulm...
Saturday, December 22, 2012
chest clinical casesDry Cough and Clubbingin a 45-Year-Old WomanSubmitted byJamie L. Garfield, MDFellowPulmonary and Criti...
History•   A 45-year-old white female presents to pulmonary clinic for evaluation of increasing chest    tightness, cough ...
Physical Exam• her heart rate is elevated at 112 beats per minute.• Oxygen saturation on 2 liters of oxygen via nasal  can...
Lab• White blood cell count 12,900/mm3,• Hemoglobin 15.5 mg/dl,• Platelet count 473,000/mm3.• BUN 9 mg/dl, creatinine 1.0 ...
Studies• Echocardiogram:   –   left ventricular ejection fraction was 55-65% and   –   grade 1 diastolic dysfunction was n...
CXR      Saturday, December 22, 2012
Coronal view ofhigh-resolution chest CT                      Saturday, December 22, 2012
Bronchoalveolar lavageSlightly mucoid, tan fluid; cultures revealed no growth; cytology showed no evidenceof malignancy; a...
Question 1• What is the most likely diagnosis?•   A. Idiopathic pulmonary fibrosis•   B. Pulmonary alveolar proteinosis•  ...
Pulmonary Alveolar Microlithiasis                (PAM)•   is a rare disorder of unknown etiology in which microliths occup...
Question 2• Which of the following statements is true regarding  pulmonary alveolar microlithiasis?• A. Dyspnea is describ...
PAM•   is present on all continents with no particular geographic or racial distribution, is    reported equally in males ...
Question 3• PAM may be associated with all of the  following conditions/exposures EXCEPT  which of the following?•   A. Mi...
discussion• PAM has been described in many patients with no discernable risk  factors for the disease.• An increased risk ...
Question 4• Which of the following signs/symptoms  is not commonly associated with PAM?•   A. Pleural plaques•   B. Pneumo...
discussion• On gross pathology, the pleural surfaces are generally  free, though appear granular owing to the sand-like  p...
Question 5• Which of the following statements is FALSE regarding  the underlying pulmonary process in this patient?• A. Mi...
discussion•   The metabolic abnormality in PAM results in precipitation of calciferous salts in an otherwise    normal alv...
Question 6• Treatment for PAM currently includes all  of the following except?•   A. Bilateral lung transplant•   B. Gene ...
discussion• Various treatment regimens have been explored for PAM, most of which  have not altered the natural course of t...
Saturday, December 22, 2012
chest ct cases-6    Dr :anas sahle  http://www.facebook.com/dranas224
HRCT-1
HRCT-1• What is the distribution of the abnormal  densities?•   a) Bronchovascular•   b) Interlobular septal•   c) Pleural...
HRCT-1
HRCT-1• Find an example in the right lung of combined  bronchovascular and interlobular septal  thickening with distortion...
HRCT-1
Gross AppearanceThis slice of lung shows vessels, bronchi, and enlarged lymph nodes.
• Find lymph nodes.• Find the main pulmonary artery.• The adjacent thinner-walled vessel is the vein.• Find and outline a ...
Gross AppearanceThis slice of lung shows vessels, bronchi, and enlarged lymph nodes.
Histologic AppearanceThis picture shows thickening of the interstitium.
• Find an airway and name its type.• Find the accompanying pulmonary artery  branch.• Find and identify 5 rounded, interst...
Histologic Appearance   Bronchiole (airway has no cartilage)This picture shows thickening of the interstitium.
Differential diagnosis• Differential diagnosis of nodular  bronchovascular and interlobular septal  thickening on HRC:.......
Differential diagnosis• Differential diagnosis of nodular  bronchovascular and interlobular septal  thickening on HRC:    ...
Differential diagnosis• Differential diagnosis of nodular bronchovascular and  interlobular septal thickening on HRC:     ...
Diagnosis:Chronic sarcoidosis
Summary of diagnostic features of         sarcoidosis on HRCT• Bronchovascular, interlobular septal and  pleural thickenin...
Saturday, December 22, 2012
Collicum EXAM    Respiratory                  12/22/2012
A1.                                       •                              IDSA    Neutropenia                         Cefep...
A2    . IDSA                                   •                       :Neutropenia                          empiricalAmox...
A3       •     .A     .B     .C     .D      .E
A4                             •           coccidioidal     . Amphotericin-B .A     •          Caspofungin .B     •       ...
A5                    •                   .A                   .B                   .C                   .D     .Prednison...
A6                               •                               •exudate                        •                        ...
A7                                        •                                       .A                amebic liver abscessAs...
A8                                                 •                                                .A                    ...
A9                        •                        •                        •  Cardiac tamponade .A .Dresslers syndrome .B...
A10                                            •obstructive                                .A                             ...
Saturday, December 22, 2012
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  1. 1. Anwser,s Dr :ANAS SAHLE 1. Chest xr cases. 2. Chest clinical case. 3. Chest ct cases. 4. Collicum exam.:http://www.facebook.com/dranas224 Saturday, December 22, 2012
  2. 2. chest xr cases Dr :anas sahle http://www.facebook.com/dranas224
  3. 3. CXR-26-a
  4. 4. CXR26-b
  5. 5. CXR26-c
  6. 6. CXR26-dDiagnosis for CXR26 is: Ankylosing Spondylitis Bamboo spine
  7. 7. CXR27Diagnosis is: Aneurysm Arch of Aorta
  8. 8. CXR28-a
  9. 9. CXR28-bOld film
  10. 10. CXR28: Aneurysm Arch of Aorta Leaking Blood into Pleural Space• Mediastinal mass• Calcification of periphery evident along upper margin• Loss of silhouettes of – aortic knob – left heart margin – left diaphragm• Left pleural effusion• Tracheal indentation• Lateral view• Middle mediastinal mass• Calcification of periphery in lateral view• left diaphragm not visible due to fluid in pleural space Saturday, December 22, 2012
  11. 11. CXR29Diagnosis is: Pectus Excavatum
  12. 12. Pectus Excavatum• Indistinct right heart margin.• Vague density in right lower lung field• Lateral view• reveals protruding sternum and flattening heart Saturday, December 22, 2012
  13. 13. CXR30-aDiagnosis is: Pulmonary Sequestration
  14. 14. CXR30-b Aortogram
  15. 15. CXR30-cAortogram
  16. 16. Pulmonary Sequestration• Anomalous Arterialization of Lung:• Increased vascular markings at right base• Smaller right pulmonary arteryBig anomalous artery arising from aorta supplying right lung Saturday, December 22, 2012
  17. 17. Saturday, December 22, 2012
  18. 18. chest clinical casesDry Cough and Clubbingin a 45-Year-Old WomanSubmitted byJamie L. Garfield, MDFellowPulmonary and Critical Care MedicineTemple University School of MedicinePhiladelphia, PennsylvaniaVictor Kim, MDAssistant Professor of MedicineTemple University School of MedicinePhiladelphia, Pennsylvania
  19. 19. History• A 45-year-old white female presents to pulmonary clinic for evaluation of increasing chest tightness, cough and dyspnea.• She has a history of chronic respiratory symptoms since childhood and frequent exacerbations of bronchitis, but no history of respiratory failure.• She reports that until 1 year ago she was limited by mild pleuritic chest tightness and shortness of breath with heavy exertion.• She now reports daily symptoms of fatigue, dyspnea, and exercise intolerance with minimal exertion.• She has persistent dry cough and occasionally expectorates granular mucus.• She has been using 3 liters per minute of supplemental oxygen via nasal cannula for the past year.• Her past medical history is significant for polycythemia, gastroesophageal reflux disease, fibronodular breast disease, chronic tinnitus with hearing loss and genital herpes.• Her current medications include famotidine, diltiazem, valacyclovir, inhaled fluticasone, salmeterol and albuterol.• She has a 30 pack-year smoking history, having quit smoking 5 years ago.• She drinks 1-2 beers per week and she denies illicit drug use.• She is a homemaker and reports no occupational exposures.• Her parents, siblings and 2 children (ages 16 and 24) are alive and well with no respiratory disease or malignancy. Saturday, December 22, 2012
  20. 20. Physical Exam• her heart rate is elevated at 112 beats per minute.• Oxygen saturation on 2 liters of oxygen via nasal cannula is 89%.• Her vital signs are otherwise normal.• Her head and neck exam is benign.• Her pulmonary exam is significant for diffuse inspiratory and expiratory dry crackles, more prominent at the bases bilaterally.• Cardiac exam reveals regular rhythm with no murmurs, rubs or gallops.• There is clubbing but no cyanosis or edema of her extremities. Saturday, December 22, 2012
  21. 21. Lab• White blood cell count 12,900/mm3,• Hemoglobin 15.5 mg/dl,• Platelet count 473,000/mm3.• BUN 9 mg/dl, creatinine 1.0 mg/dl,• calcium 8.8 mg/dl and phosphate 4.9 mg/dl.• PT, PTT, electrolytes, glucose and liver function tests were within normal limits.• Arterial blood gas on 3L/min supplemental oxygen revealed a – pH of 7.39, PCO2 40 mm Hg and PaO2 62 mm Hg. Saturday, December 22, 2012
  22. 22. Studies• Echocardiogram: – left ventricular ejection fraction was 55-65% and – grade 1 diastolic dysfunction was noted; – right ventricle was mildly dilated and had mildly depressed systolic function; – pulmonary artery systolic pressure was estimated to be 48-52 mm Hg; right atrium was mildly dilated and there was mild tricuspid regurgitation.• Cardiac Catheterization: PAP: 30/6/13; PCWP: 2; CO: 3.38; CI: 2.16.• Pulmonary Function Tests: – FEV1/ FVC: 74%; – FEV1: 0.96 L, 39%; – FVC: 1.29L, 42%; – TLC: 2.27L, 53%; RV: 1.14L, 79%; DLCO: 3.11L, 57%.• 6-Minute Walk Test: – Resting SpO2: 86% RA; 92% on 2L/min; 8L/min was required to maintain oxygen saturation above 90% – at the end of 6 minutes; the patient was able to walk 211 meters. Saturday, December 22, 2012
  23. 23. CXR Saturday, December 22, 2012
  24. 24. Coronal view ofhigh-resolution chest CT Saturday, December 22, 2012
  25. 25. Bronchoalveolar lavageSlightly mucoid, tan fluid; cultures revealed no growth; cytology showed no evidenceof malignancy; a few white blood cells were noted, predominantly macrophages;laminated calcified concretions and debris were also present.Von Kossa stain positive. Saturday, December 22, 2012
  26. 26. Question 1• What is the most likely diagnosis?• A. Idiopathic pulmonary fibrosis• B. Pulmonary alveolar proteinosis• C. Diffuse alveolar hemorrhage syndrome• D. Pulmonary alveolar microlithiasis• E. Broncheoloalveolar carcinomatosis Saturday, December 22, 2012
  27. 27. Pulmonary Alveolar Microlithiasis (PAM)• is a rare disorder of unknown etiology in which microliths occupy the alveolar space (1).• The mean age of diagnosis is in the fourth decade of life, although the onset of disease may occur in childhood (2, 3).• Idiopathic pulmonary fibrosis (IPF) tends to present later in life than PAM.• Dyspnea and hypoxemia are common to both disease entities, but the honeycombing classically seen on HRCT in IPF would not be expected in PAM.• Pulmonary alveolar proteinosis (PAS), another alveolar filling disorder, is also a rare but deadly entity.• Patients with PAS may have dry crackles and clubbing as in PAM.• The patchy ground glass opacities with a “crazy-paving” pattern described in PAS can usually be distinguished from the microcalcifications seen on HRCT in PAM. Rarely, “crazy- paving” can be seen in PAM (4).• Bronchoalveolar carcinomatosis can radiographically mimic many diseases with alveolar infiltrates.• Classically this condition is less diffuse than PAM, and as such, hypoxemia and diffusion impairment are less common.• Diffuse alveolar hemorrhage (DAH) can present with hypoxia and diffuse alveolar infiltrates similar to PAM.• The onset of DAH is usually more abrupt than PAM.• While frank hemoptysis can be absent in up to one third of DAH cases, hemosiderin-laden macrophages are commonly found in BAL. Saturday, December 22, 2012
  28. 28. Question 2• Which of the following statements is true regarding pulmonary alveolar microlithiasis?• A. Dyspnea is described in proportion to the severity of the radiographic abnormalities.• B. The diagnosis can only be made by lung biopsy demonstrating microliths within the alveoli.• C. Pathologically, the lungs are soft and boggy.• D. Familial disease is inherited in an autosomal dominant fashion.• E. PAM is found in all geographic regions, across all races, and equally between men and women. Saturday, December 22, 2012
  29. 29. PAM• is present on all continents with no particular geographic or racial distribution, is reported equally in males and females, and has been described in all age groups, but most frequently from birth to age 40.• A family history was noted in 37% of patients in one large review .• Simultaneous cases of PAM have been described in siblings, supporting an autosomal recessive inheritance pattern.• A hallmark feature of PAM is the striking dissociation between clinical and radiographic findings.• Often there is extensive radiographic evidence of disease and only mild symptomatology• Children that present with PAM are often asymptomatic.• The diagnosis can often be made in the absence of a biopsy, with radiographic imaging demonstrating the classic “sand-storm” appearance.• Bronchoalveolar lavage may demonstrate laminated calcified concretions.• Diagnosis can be confirmed with open, transbronchial or transthoracic needle biopsy.• Histologically, the characteristic finding is that of bluish-violet bodies of varying shape and sizes, many of which are fissured with radial cracks .• On gross pathology, lungs are hard and gritty and do not collapse upon removal from thorax . Saturday, December 22, 2012
  30. 30. Question 3• PAM may be associated with all of the following conditions/exposures EXCEPT which of the following?• A. Milk-alkali syndrome• B. Calcium containing powdered tobacco• C. Inflammatory bowel disease• D. Printing ink• E. Renal transplant Saturday, December 22, 2012
  31. 31. discussion• PAM has been described in many patients with no discernable risk factors for the disease.• An increased risk of PAM has been reported in individuals with exposure to printing ink and among those with a history of smoking powdered tobacco containing calcium salts .• Systemic diseases associated with calcium and phosphate deregulation, such as milk-alkali syndrome renal transplant and nephrolithiasis have been linked to PAM.• It is not known if these associations are causational or coincidental.• Inflammatory bowel disease, while can be associated with electrolyte abnormalities related to malabsorption, has not been described in patients with PAM. Saturday, December 22, 2012
  32. 32. Question 4• Which of the following signs/symptoms is not commonly associated with PAM?• A. Pleural plaques• B. Pneumothorax• C. Hemoptysis• D. Lithoptysis• E. Emphysema Saturday, December 22, 2012
  33. 33. discussion• On gross pathology, the pleural surfaces are generally free, though appear granular owing to the sand-like particles that can be seen and felt beneath.• Pleural plaques are not commonly seen in PAM .• Emphysematous blebs are commonly seen in patients with PAM and may represent early lung fibrosis.• Pneumothorax resulting from bleb rupture is not rare .• Some patients report coughing up blood, while others describe lithoptysis, or expectorating granular-like mucus or microliths with coughing. Saturday, December 22, 2012
  34. 34. Question 5• Which of the following statements is FALSE regarding the underlying pulmonary process in this patient?• A. Microliths are derived from the alveolar capillary blood and not a result of pathological changes in the tissue cells of the alveoli.• B. Inborn errors in metabolism at the alveolar interface leads to local accumulation of calcium salts.• C. Alveolar hemorrhage is commonly associated with this disease.• D. PAM usually occurs in patients without evidence of systemic derangement in calcium metabolism.• E. Dysfunction of SLC34A2 may reduce the clearance of phosphate leading to the formation of microliths. Saturday, December 22, 2012
  35. 35. discussion• The metabolic abnormality in PAM results in precipitation of calciferous salts in an otherwise normal alveolus.• The components of the microliths are therefore thought to be derived from the alveolar capillary blood and not a result of pathological changes in the tissue cells of the alveoli .• It has been suggested that inborn errors in metabolism at the alveolar interface lead to increased alkalinity or mucopolysaccharide deposition, promoting the local accumulation of calcium salts.• Studies of calcium metabolism in affected patients have been consistently normal, suggesting it is unlikely that PAM is due to a systemic derangement of calcium metabolism .• Hemoptysis is not uncommon in PAM when inspissated microliths irritate and erode bronchial epithelium. Diffuse alveolar hemorrhage, however, is not known to be associated with PAM.• Homozygous inactivating mutations in the SLC34A2 gene, are present in patients with PAM.• SLC34A2 encodes a sodium phosphate transporter that is highly expressed in alveolar type II cells.• Normally, type II alveolar cells recycle and degrade surfactant and subsequently release phosphate into the alveolar space.• Dysfunction of this sodium phosphate transporter may reduce the clearance of phosphate from the alveolar space, thereby leading to the formation of microliths . Saturday, December 22, 2012
  36. 36. Question 6• Treatment for PAM currently includes all of the following except?• A. Bilateral lung transplant• B. Gene replacement therapy• C. Whole lung lavage• D. Systemic steroids• E. Dibisphosphonates Saturday, December 22, 2012
  37. 37. discussion• Various treatment regimens have been explored for PAM, most of which have not altered the natural course of the disease.• Borrowing from the therapeutic strategy for PAS, whole lung lavage has been tried without success in patients with PAM.• Systemic corticosteroids and bisphosphonates have also been used but fail to preserve lung function or improve symptoms.• Bilateral lung transplant remains the only option for patients with severe symptoms related to PAM .• There remains very little information on long term survival and whether the disease will return in the donor lungs .• As more is learned about the SLC34A2 gene and its role in PAM, there is growing interest in the possibility of gene replacement therapy to treat PAM .• While this therapy is not available today, early data suggest that targeting phosphate rather than calcium metabolism may be beneficial for the treatment of PAM. Saturday, December 22, 2012
  38. 38. Saturday, December 22, 2012
  39. 39. chest ct cases-6 Dr :anas sahle http://www.facebook.com/dranas224
  40. 40. HRCT-1
  41. 41. HRCT-1• What is the distribution of the abnormal densities?• a) Bronchovascular• b) Interlobular septal• c) Pleural• d) Centrilobular
  42. 42. HRCT-1
  43. 43. HRCT-1• Find an example in the right lung of combined bronchovascular and interlobular septal thickening with distortion of the architecture.• Find an example in the left lung of thickened bronchovascular interstitium.• Find a centrilobular nodule, representing thickening of the terminal bronchiolovascular interstitium, in the left lung.
  44. 44. HRCT-1
  45. 45. Gross AppearanceThis slice of lung shows vessels, bronchi, and enlarged lymph nodes.
  46. 46. • Find lymph nodes.• Find the main pulmonary artery.• The adjacent thinner-walled vessel is the vein.• Find and outline a longitudinally-cut, segmental bronchus with thickened bronchovascular interstitium that narrows the lumen.• This bronchovascular interstitial involvement corresponds to that seen in the HRCT image above.• Architectural distortion may result.• Find other airways cut in cross-section that are also narrowed.
  47. 47. Gross AppearanceThis slice of lung shows vessels, bronchi, and enlarged lymph nodes.
  48. 48. Histologic AppearanceThis picture shows thickening of the interstitium.
  49. 49. • Find an airway and name its type.• Find the accompanying pulmonary artery branch.• Find and identify 5 rounded, interstitial, cellular structures.• Find and identify the composition of the pink matrix.
  50. 50. Histologic Appearance Bronchiole (airway has no cartilage)This picture shows thickening of the interstitium.
  51. 51. Differential diagnosis• Differential diagnosis of nodular bronchovascular and interlobular septal thickening on HRC:............• Histologic differential diagnosis:………
  52. 52. Differential diagnosis• Differential diagnosis of nodular bronchovascular and interlobular septal thickening on HRC: –Sarcoidosis. –lymphangitic tumor. –Lymphoma. –Kaposis sarcoma• Histologic differential diagnosis:………
  53. 53. Differential diagnosis• Differential diagnosis of nodular bronchovascular and interlobular septal thickening on HRC: – Sarcoidosis. – lymphangitic tumor. – Lymphoma. – Kaposis sarcoma• Histologic differential diagnosis: – Infectious granulomatous disease (tuberculous or fungal). – hypersensitivity pneumonia. – reaction to tumor or drug should be considered.
  54. 54. Diagnosis:Chronic sarcoidosis
  55. 55. Summary of diagnostic features of sarcoidosis on HRCT• Bronchovascular, interlobular septal and pleural thickening• Upper lung predominance common• Architectural distortion frequent
  56. 56. Saturday, December 22, 2012
  57. 57. Collicum EXAM Respiratory 12/22/2012
  58. 58. A1. • IDSA Neutropenia Cefepime .A • Ceftazidime .B • Imipenem .C • Meropenem .D •Tazobactam and Piperacillin sodium .E •
  59. 59. A2 . IDSA • :Neutropenia empiricalAmoxicillin-clavulanate + Moxifloxacin .A •Amoxicillin-clavulanate + Ciprofloxacin .B • Amoxicillin-clavulanate + Levofloxacin .C •Amoxicillin-clavulanate + Azithromycin .D • Cefixime .E •
  60. 60. A3 • .A .B .C .D .E
  61. 61. A4 • coccidioidal . Amphotericin-B .A • Caspofungin .B • .Fluconazol .C • .Voriconazole .D •
  62. 62. A5 • .A .B .C .D .Prednisone .E
  63. 63. A6 • •exudate • • . .A parapneumonicPH .B .C .D .E
  64. 64. A7 • .A amebic liver abscessAspergillus .B .C Chylothorax .D pulmonary infarction .E
  65. 65. A8 • .A lupus pleuritis Urinothorax LDH .B .CIU/LD LDH .D .E congestive heart failure
  66. 66. A9 • • • Cardiac tamponade .A .Dresslers syndrome .B Pulmonary Embolus .C .D .E
  67. 67. A10 •obstructive .A atelectasis .B . Nephrotic syndrome .C . Pulmonary Embolus .DHypothyroid .E
  68. 68. Saturday, December 22, 2012

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