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C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
C:\Documents And Settings\User\Desktop\Stomach Histology
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C:\Documents And Settings\User\Desktop\Stomach Histology

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  • 1. DIGESTIVE SYSTEM Stomach Histology Assoc. Prof. Dr. Karim Al-Jashamy IMS/MSU 2010
  • 2. Stomach Anatomy: • Openings – Gastroesophageal : To esophagus – Pyloric: To duodenum • Regions – Cardiac – Fundus – Body – Pyloric
  • 3. Regions of the Stomach
  • 4. Layers of the Gastrointestinal Tract • Mucosa – Epithelium, CT, a little muscle • Submucosa – CT, glands • Muscularis propria – Muscles • Serosa – CT
  • 5. Mucosa Epithelium Differs with location, functions Lamina propria Loose CT, blood and lymph vessels Muscularis mucosae Thin layer with smooth muscle
  • 6. SUBMUCOSA Loose/Dense irregular CT Supports mucosa Contains large blood vessels, nerves, lymphatics MUSCULARIS PROPRIA Two layers Peristaltic contractions
  • 7. SEROSA/ADVENTITIA Loose CT Major vessels, nerves, adipose
  • 8. The Stomach
  • 9. Gastric Glands of Stomach
  • 10. STOMACH x10 LP MM
  • 11. GASTRIC GLAND
  • 12. Stomach Section of the gastric glands in the fundus of the stomach. Note the superficial mucus-secreting epithelium. Parietal cells (light-stained) predominate in the mid and upper regions of the glands; chief (zymogenic) cells (dark-stained) predominate in the lower region of the gland. MM, muscularis mucosae.
  • 13. Histology LAYERS 1. Mucosa • The first main layer. • consists of an epithelium (simple columnar epithelium), the lamina propria underneath, and a thin layer of smooth muscle called the muscularis mucosae 2. Submucosa • Lies under the mucosa • Consists of fibrous connective tissue, separating the mucosa from the next layer. • The submucosal nerve plexus is in this layer.
  • 14. 3. Muscularis externa • Consists of three layers: i. inner oblique layer – responsible for creating the motion that churns and physically breaks down the food i. middle circular layer – constricted at the pylorus forming pyloric sphincter, which controls the movement of chyme into the duodenum i. outer longitudinal layer – Auerbach's plexus is found between this layer and the middle circular layer.
  • 15. 4. Serosa • outside the muscularis externa • consisting of layers of connective tissue continuous with the peritoneum
  • 16. Stomach Histology • Gastric pits: Openings for gastric glands – Contain cells • Surface mucous: Mucus • Mucous neck: Mucus – Parietal: Hydrochloric acid and intrinsic factor – Chief: Pepsinogen – Endocrine: Regulatory hormones
  • 17. Normal Histological Features: • The gastric mucosa consists of surface epithelium, gastric pits and gastric glands. • The gastric glands extend from the muscular mucosa extend into the stomach lumen via gastric pits. • The cells lining the surface and gastric pits are identical throughout the stomach • Glands differ in different regions of the stomach. • Gastric pits occupy approximately 25% of the mucosa. Pits lie parallel to one another. • There is more lamina propria separating the pits than between the glands. • In normal gastric biopsy degree of pit and glandular separation should be same throughout the biopsy.
  • 18. • Cardia- Small area of predominantly mucus secreting glands surrounding the entrance of the esophagus. • The pits are shorter than the antropyloric pits. •Fundus and body Major histological region. Consists of straight, tubular glands.  Strands of muscularis mucosae extend between the glands from the base. The glands secrete gastric juices as well as protective mucus.
  • 19. • FUNDAL PART OF THE STOMACH Stained with haematoxylin and eosin 1 - tunica mucosa 2 - tunica submucosa 3 - tunica muscularis propria 4 - tunica serosa 5 - epithelium of the mucosa 6 - lamina propria of the mucosa (contains glands) 7 - muscularis mucosae
  • 20. • Pylorus- Branched glands open into deep irregular shaped pits. Composed of mucus secreting cells. • Mucus secreted by pyloric glands lubricate and protect entrance to the duodenum. Scattered 'G' cells (endocrine cells), secrete gastrin. • Note: Gastric mucosa forms a barrier to diffuse of gastric acid from the gastric lumen.
  • 21. PYLORIC PART OF THE STOMACH Stained with haematoxylin and eosin 1 - tunica mucosa 2 - tunica submucosa 3 - tunica muscularis propria 5 - lamina propria of the mucosa (contains glands) 7 - gastric pits in the mucosa 8 - muscularis mucosae
  • 22. Types of cells present in the stomach • Mucous secreting cells (goblet cells)- – Line the luminal surface of the stomach and gastric pits and gastric glands. – produce mucus and bicarbonate. •Mucous neck cells- Present in the neck of the gland. Produce mucin. •Parietal cells (oxyntic cells) Distributed throughout the length of the gland, but numerous in the middle portion.  Large, rounded cells with eosinophilic cytoplasm and centrally located nucleus. Produce gastric acid.
  • 23. • Chief cells (peptic or zymogenic cells) – Clustered at the base of the gland. – Identified by basally located nuclei and strongly basophilic granular cytoplasm. Produce pepsinogen, digests protein.
  • 24. The Lamina Propria • Consists of a layer of areolar tissue that contains: – blood vessels – sensory nerve endings – lymphatic vessels – smooth muscle cells – scattered areas of lymphoid tissue
  • 25. Assignment 1

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