14. anaeli. use of cannabis on ibd
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  • IBD. Chronic inflammation of the intestines. Ultimately affects. Immune system. Different types = different symptoms. Abdominal pain, vomiting, diarrhea, loss of appetite, weight loss, rectal pain, fever, night sweats, rectal bleeding.
  • Surgeries and medication: anti-inflammatory agents, topical antibiotics, and immune-modulators.
  • Medicine for 5,000 years. Cannabis-cannabinoids-cannabidiol. Cannabinoids have a direct involvement with the anti-inflammatory effect of cannabis. CB1 receptors are located in the brain and CB2 in the immune system.
  • Most important cannabinoid. THC mimics or blocks the actions of neurotransmitters (chemicals that allows neurons to communicate with each other)
  • Multiple sclerosis, ADHD, AIDS, glaucoma, insomnia, asthma, migraines, etc.
  • Positive feedback. Use of cannabidiol is helpful in normalizing intestinal functions. Abdominal pain in inflammatory diseases was reduced with the use of cannabis.
  • Abdominal pain in inflammatory diseases was reduced with the use of cannabis.Endocannabinoids (substances that are produced within the body that activate cannabinoid receptors) agonists are involved in the protection of the gut against inflammation. Reduced drugs and surgeries.
  • Still not considered safe for human consumption. Different cannabinoid structures than actual cannabinoids.The synthetic cannabinoids are liquid in their original state and solidify when they are combined with dry herbs. Unknown.
  • IBD. Marijuana, cannabinoids, THC. CB1 and CB2. Different parts of the brain. Cannabinoids, cannabidiol and endocannabinoids = reduced symptoms, specially inflammation.

14. anaeli. use of cannabis on ibd 14. anaeli. use of cannabis on ibd Presentation Transcript

  • A N A E L I S H O C K E Y L Ó P E ZU N I V E R S I T Y O F P U E R T O R I C OD E P A R T M E N T O F C H E M I S T R YB I O L 3 0 9 5The use of Cannabis sativa as an anti-inflammatory for Crohn’s Disease.
  • Crohn’s Disease What is it? Inflammatory Bowel Disease (IBD) Symptoms Abdominal pain Inflammation Immune system Vomiting Diarrhea Loss of appetite/weight loss Rectal pain/rectal bleeding
  • Crohn’s Disease Reasons Treatments Anti-inflammatory agents Topical Antibiotics Immune-modulators No medical cure. (Schoenfeld & Wu. 2010)
  • Cannabis sativa What is it? Composition Cannabinoids Direct involvement with the anti-inflammatory effect (Burstein,Zurier. 2009) Cannabidiol Cannabinoid receptors CB1 and CB2 (Pertwee. 2008) CB1 = brain CB2 = immune system
  •  THC (Δ9-tetrahydrocannabinol) Mediated by the CB1 receptor (Cooper, Haney. 2009) How does THC affect the brain? Neurotransmiters Specific effects on each part of the brain
  • Cannabis sativa Other sicknesses Multiple sclerosis ADHD AIDS Glaucoma Insomnia Asthma Migraines
  • Cannabis on IBD Recent treatment Studies Mice Inflammation Croton oil Dinitrobenzene acid Results: Cannabidiol is active when there is an inflammatory stimulus.(Capasso, et al. 2008) Cannabidiol reduces colon injury. (Borrelli, et al. 2009)
  • Cannabis on IBD Humans Surveys Results Relieved abdominal pain, diarrhea and reduced appetite. (Lal,et al. 2011)• Endocannabinoids Protection of the gut against inflammation. (Sabatino, et al. 2011) Reduced symptoms• Amount of drugs and surgeries needed were reduced. (Naftali, et al.2011)
  • Legalization Issues Countries Synthetic cannabis Structure State Health effects Unknown according to the Drug Foundation.
  • Conclusion Crohn’s Disease IBD Cannabis sativa Cannabinoids Cannabidiol Cannabinoid receptors The brain and immune system Reduced symptoms
  • References 1. Borrelli F, Aviello G, Romano B, Orlando P, Capasso R, Maiello F, Guadagno F,Petrosino S, Capasso F, Di Marzo V, Izzo A. 2009. Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in amurine model of colitis. J Mol Med 87:1111–1121. Doi :10.1007/s00109-009-0512-x 2. Burstein S, Zurier R. 2009. Cannabinoids, Endocannabinoids, and RelatedAnalogs in Inflammation. [Internet] [Cited 2012 Nov 24] AAPS J.11(1): 109–119.doi: 10.1208/s12248-009-9084-5 Available from:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664885/ 3. Capasso R, Borrelli F, Aviello G, Romano B, Scalisi C, Capasso F, Izzo AA. 2008.Cannabidiol, extracted from cannabis sativa, selectively inhibits inflammatoryhypermotility in mice. Br J Pharmacol 154(5):1001-8. 4. Cooper Z, Haney M. 2009. Actions of delta-9-tetrahydrocannabinol in cannabis.Int Rev Psychiatry. [Internet] [Cited 2012 Nov 24] 21(2): 104–112. doi:10.1080/09540260902782752 Available from:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731700/
  • References 5. Di Sabatino A, Battista N, Biancheri P, Rapino C, Rovedatti L, Astarita G, Vanoli A, DaineseE, Guerci M, Piomelli D, Pender S, Pender L, Pender F, MacDonald T, MacDonald T,Maccarrone M, Corazza G, Corazza R. 2011. Mucosal Immunology 4: 574–583;doi:10.1038/mi.2011.18 Available from:http://www.nature.com/mi/journal/v4/n5/full/mi201118a.html 6. Lal S, Prasad N, Ryan M, Tangri S, Silverberg M, Gordon A, Steinhart H. 2011. Cannabis useamongst patients with inflammatory bowel disease. European Journal of Gastroenterology &Hepatology 23(10):891-896 7. Naftali T, Bar Lev L, Yableknovitz D, Half E and Konikoff F. 2011. Treatment of Crohn’sDisease with Cannabis: An Observational Study. [Internet]. [Cited 2012 Nov 24] 13:455-457Available from: http://www.letfreedomgrow.com/cmu/Crohns-ar11aug-01.pdf 8. Pertwee RG. 2008. Ligands that target cannabinoid receptors in the brain: from THC toanandamide and beyond. Institute of Medical Sciences, Aberdeen, UK. 13(2):147-59. 9. Schoenfeld A, Wu G. 2010. Crohn’s Disease. [Internet] [Cited 2012 Nov 24] Available from:http://www.medicinenet.com/crohns_disease/article.htm 10. Synthetic cannabinoids. Available from: http://www.drugfoundation.org.nz/synthetic-cannabinoids
  • Questions?