IBD. Chronic inflammation of the intestines. Ultimately affects. Immune system. Different types = different symptoms. Abdominal pain, vomiting, diarrhea, loss of appetite, weight loss, rectal pain, fever, night sweats, rectal bleeding.
Surgeries and medication: anti-inflammatory agents, topical antibiotics, and immune-modulators.
Medicine for 5,000 years. Cannabis-cannabinoids-cannabidiol. Cannabinoids have a direct involvement with the anti-inflammatory effect of cannabis. CB1 receptors are located in the brain and CB2 in the immune system.
Most important cannabinoid. THC mimics or blocks the actions of neurotransmitters (chemicals that allows neurons to communicate with each other)
Multiple sclerosis, ADHD, AIDS, glaucoma, insomnia, asthma, migraines, etc.
Positive feedback. Use of cannabidiol is helpful in normalizing intestinal functions. Abdominal pain in inflammatory diseases was reduced with the use of cannabis.
Abdominal pain in inflammatory diseases was reduced with the use of cannabis.Endocannabinoids (substances that are produced within the body that activate cannabinoid receptors) agonists are involved in the protection of the gut against inflammation. Reduced drugs and surgeries.
Still not considered safe for human consumption. Different cannabinoid structures than actual cannabinoids.The synthetic cannabinoids are liquid in their original state and solidify when they are combined with dry herbs. Unknown.
IBD. Marijuana, cannabinoids, THC. CB1 and CB2. Different parts of the brain. Cannabinoids, cannabidiol and endocannabinoids = reduced symptoms, specially inflammation.
14. anaeli. use of cannabis on ibd
A N A E L I S H O C K E Y L Ó P E ZU N I V E R S I T Y O F P U E R T O R I C OD E P A R T M E N T O F C H E M I S T R YB I O L 3 0 9 5The use of Cannabis sativa as an anti-inflammatory for Crohn’s Disease.
Crohn’s Disease What is it? Inflammatory Bowel Disease (IBD) Symptoms Abdominal pain Inflammation Immune system Vomiting Diarrhea Loss of appetite/weight loss Rectal pain/rectal bleeding
Crohn’s Disease Reasons Treatments Anti-inflammatory agents Topical Antibiotics Immune-modulators No medical cure. (Schoenfeld & Wu. 2010)
Cannabis sativa What is it? Composition Cannabinoids Direct involvement with the anti-inflammatory effect (Burstein,Zurier. 2009) Cannabidiol Cannabinoid receptors CB1 and CB2 (Pertwee. 2008) CB1 = brain CB2 = immune system
THC (Δ9-tetrahydrocannabinol) Mediated by the CB1 receptor (Cooper, Haney. 2009) How does THC affect the brain? Neurotransmiters Specific effects on each part of the brain
Cannabis on IBD Recent treatment Studies Mice Inflammation Croton oil Dinitrobenzene acid Results: Cannabidiol is active when there is an inflammatory stimulus.(Capasso, et al. 2008) Cannabidiol reduces colon injury. (Borrelli, et al. 2009)
Cannabis on IBD Humans Surveys Results Relieved abdominal pain, diarrhea and reduced appetite. (Lal,et al. 2011)• Endocannabinoids Protection of the gut against inflammation. (Sabatino, et al. 2011) Reduced symptoms• Amount of drugs and surgeries needed were reduced. (Naftali, et al.2011)
Legalization Issues Countries Synthetic cannabis Structure State Health effects Unknown according to the Drug Foundation.
Conclusion Crohn’s Disease IBD Cannabis sativa Cannabinoids Cannabidiol Cannabinoid receptors The brain and immune system Reduced symptoms
References 1. Borrelli F, Aviello G, Romano B, Orlando P, Capasso R, Maiello F, Guadagno F,Petrosino S, Capasso F, Di Marzo V, Izzo A. 2009. Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in amurine model of colitis. J Mol Med 87:1111–1121. Doi :10.1007/s00109-009-0512-x 2. Burstein S, Zurier R. 2009. Cannabinoids, Endocannabinoids, and RelatedAnalogs in Inflammation. [Internet] [Cited 2012 Nov 24] AAPS J.11(1): 109–119.doi: 10.1208/s12248-009-9084-5 Available from:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664885/ 3. Capasso R, Borrelli F, Aviello G, Romano B, Scalisi C, Capasso F, Izzo AA. 2008.Cannabidiol, extracted from cannabis sativa, selectively inhibits inflammatoryhypermotility in mice. Br J Pharmacol 154(5):1001-8. 4. Cooper Z, Haney M. 2009. Actions of delta-9-tetrahydrocannabinol in cannabis.Int Rev Psychiatry. [Internet] [Cited 2012 Nov 24] 21(2): 104–112. doi:10.1080/09540260902782752 Available from:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731700/
References 5. Di Sabatino A, Battista N, Biancheri P, Rapino C, Rovedatti L, Astarita G, Vanoli A, DaineseE, Guerci M, Piomelli D, Pender S, Pender L, Pender F, MacDonald T, MacDonald T,Maccarrone M, Corazza G, Corazza R. 2011. Mucosal Immunology 4: 574–583;doi:10.1038/mi.2011.18 Available from:http://www.nature.com/mi/journal/v4/n5/full/mi201118a.html 6. Lal S, Prasad N, Ryan M, Tangri S, Silverberg M, Gordon A, Steinhart H. 2011. Cannabis useamongst patients with inflammatory bowel disease. European Journal of Gastroenterology &Hepatology 23(10):891-896 7. Naftali T, Bar Lev L, Yableknovitz D, Half E and Konikoff F. 2011. Treatment of Crohn’sDisease with Cannabis: An Observational Study. [Internet]. [Cited 2012 Nov 24] 13:455-457Available from: http://www.letfreedomgrow.com/cmu/Crohns-ar11aug-01.pdf 8. Pertwee RG. 2008. Ligands that target cannabinoid receptors in the brain: from THC toanandamide and beyond. Institute of Medical Sciences, Aberdeen, UK. 13(2):147-59. 9. Schoenfeld A, Wu G. 2010. Crohn’s Disease. [Internet] [Cited 2012 Nov 24] Available from:http://www.medicinenet.com/crohns_disease/article.htm 10. Synthetic cannabinoids. Available from: http://www.drugfoundation.org.nz/synthetic-cannabinoids