CROMOLYN SODIUMAmitsinh ViholExam No-43                     1
CROMOLYN SODIUMAccording to WHO,• Worldwide 235 millions patient of asthma• In India, 15-20 million patient (15-20% are 5-...
CROMOLYN SODIUMPHARMACOLOGY• Pharmacologic class: Chromone derivative• Therapeutic class: Mast cell  stabilizer, antiasthm...
CROMOLYN SODIUMAdverse reactions• CNS: headache, dizziness• Respiratory: wheezing, cough, nasal irritation, stuffy  nose, ...
CROMOLYN SODIUMINDICATION-• Prophylactic in the management of patients with bronchial  asthma.• Prevention of exercise-ind...
CROMOLYN SODIUMDOSAGE-Usual Adult Dose for Asthma -- Maintenance:• Nebulization solution: 20 mg 4 times a day at regular i...
CROMOLYN SODIUMCOMPETITOR-• Fintal(Abbot)-(94RS/5 vial of each 2ml)• Nalcrom (Sanofi-Aventis)-($10/20ml)• Nasalcrom(Presti...
CROMOLYN SODIUMSTORAGE & LABELLING-•   Store at 20°-25°C (68°-77°F).•   Do not use if solution is discolored or contains a...
CROMOLYN SODIUMPACKAGING & AVAILABLE DOSAGE FORM-• Packed in vial which is made from a low density polyethylene  (LDPE) re...
CROMOLYN SODIUMPRICING• 90Rs/5 vial Each contain 2ml• 999Rs/Cartoon of 60 Vials• 1999Rs/Cartoon of 120 vials              ...
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CROMOLYN SODIUM• REFRENCE-• Rang & Dale’s Pharmacology by H.P.Rang, M.M.Dale, et all.,6th  edition, Page no-364-365• http:...
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Cromolyn sodium

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Cromolyn sodium

  1. 1. CROMOLYN SODIUMAmitsinh ViholExam No-43 1
  2. 2. CROMOLYN SODIUMAccording to WHO,• Worldwide 235 millions patient of asthma• In India, 15-20 million patient (15-20% are 5-11 year old children)• 1,80,000 death every year in the world.• First line agent into mild to moderate asthma• Safer treatment, less adverse effect. 2
  3. 3. CROMOLYN SODIUMPHARMACOLOGY• Pharmacologic class: Chromone derivative• Therapeutic class: Mast cell stabilizer, antiasthmatic, ophthalmic decongestant.• Pregnancy risk category B• Mechanism of Action-Inhibits release of histamine and reacting substances of anaphylaxis from mast cells, stabilizing the cell membrane and reducing the allergic response and inflammatory reaction. 3
  4. 4. CROMOLYN SODIUMAdverse reactions• CNS: headache, dizziness• Respiratory: wheezing, cough, nasal irritation, stuffy nose, sneezing, sore throat• GI: nausea, diarrhea, stomachache• Urinay: difficult or painful urination• Skin: rash• Other: altered taste, substernal burning, allergic reactions. 4
  5. 5. CROMOLYN SODIUMINDICATION-• Prophylactic in the management of patients with bronchial asthma.• Prevention of exercise-induced bronchospasm;• Adjunct in prevention of allergic disorders including rhinitisCONTRAINDICATIONS-• Contraindicated in those patients who have shown hypersensitivity to cromolyn sodium. 5
  6. 6. CROMOLYN SODIUMDOSAGE-Usual Adult Dose for Asthma -- Maintenance:• Nebulization solution: 20 mg 4 times a day at regular intervals.• Metered dose inhaler: 2 puffs 4 times a day at regular intervals.Usual Pediatric Dose for Asthma -- Maintenance:• Nebulization solution: > 2 years: 20 mg 4 times a day at regular intervals.• Metered dose inhaler: > 5 years: 2 puffs 4 times a day at regular intervals. 6
  7. 7. CROMOLYN SODIUMCOMPETITOR-• Fintal(Abbot)-(94RS/5 vial of each 2ml)• Nalcrom (Sanofi-Aventis)-($10/20ml)• Nasalcrom(Prestige Brands)-($9/13ml) 7
  8. 8. CROMOLYN SODIUMSTORAGE & LABELLING-• Store at 20°-25°C (68°-77°F).• Do not use if solution is discolored or contains a precipitate.• Retain in foil pouch until time of use.• PROTECT FROM LIGHT.• KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN. 8
  9. 9. CROMOLYN SODIUMPACKAGING & AVAILABLE DOSAGE FORM-• Packed in vial which is made from a low density polyethylene (LDPE) resin.• Cromolyn Sodium Inhalation Solution Unit-Dose 2 mL Vial is supplied as a colorless to pale yellow solution containing 20 mg cromolyn sodium, USP, in water for injection, USP, with 5 vials per foil pouch in cartons as listed below.• 60 vials per carton.• 120 vials per carton. 9
  10. 10. CROMOLYN SODIUMPRICING• 90Rs/5 vial Each contain 2ml• 999Rs/Cartoon of 60 Vials• 1999Rs/Cartoon of 120 vials 10
  11. 11. 11
  12. 12. CROMOLYN SODIUM• REFRENCE-• Rang & Dale’s Pharmacology by H.P.Rang, M.M.Dale, et all.,6th edition, Page no-364-365• http://www.nlm.nih.gov/medlineplus/druginfo/meds/a60104 2.html• http://www.drugs.com/mtm/cromolyn-sodium- inhalation.html• http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=AEC 8F12A-B778-4AB5-A932-FDFB620FD50B#section-10 12
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