Occur primarily children & young
Definition is based on :
Mesangial & endothelial cell
Expansion of mesangial matrix
Thickened peripheral capillary wall
Mesangial interposition into the Cap
beneath the capillary
cells with formation
of "double contours"
There is bright
peripheral loop staining
with antibody to C3 as
well as mesangial
staining. Staining for
often less intense
There are prominent
Mesangial expansion and proliferation
Primary or secondary which is more
Idiopathic type :
I , II , III depending on:
IF staining ,ultrastructural
appearance & complement profiles.
characteristic due to decrease
synthesis & consumption.
- Diagnosis by exclusion.
- There is discrete deposition in the
mesangium & subendothelial space.
- NS progressive ESRD
- non NS 85% renal survival at 10ys
- 30 – 70 % recurrence in RXT
Dense deposits disease
Deposition along the memb, tubules &
- IF +ve for C3 –ve for Ig & complexes
- Tram track C3 deposition
- High rate of recurrence in RXT 50 –
** C3,C5 & properdin deposition.
** Recurrence is unknown in RXT
Reserved for those with:
– proteinuria >3gm/day
- interstitial disease
- impaired renal function
Normal renal function :
normal protein 1 gm/kg/day +urine
Renal impairment :
0.65 – 0.8 gm/day + urine loss
Low cholesterol diet
Non specific treatment
Hyperlipidaemia < 100 mg/dl LDL
2 mg/kg every other day for 1yr
then tapered to maintenance of
20 mg every other day for 3 – 10 ys
120 mg on alternate days for12–16 /52 with
follow up .
taper to 20 – 30 mg alternate days for
Can slow the progression
*-* Aspirin 975mg/day + dipyridamol
*-* Asprin 500 mg/day + dipyridamol
75 mg/day for 3ys.
It is not felt that addition
of this group would provide further