IgG4-MGN can occur alone
Associated with IgG4-TIN
Patients with IgG4 with proteinuria
IgG4-MGN is similar to idiopathic
Thick capillary loops
GBM spikes on silver stain
IgG4 antibodies undergo ‘half-antibody
in vivo, resulting in recombined antibodies
two different binding specificities.
IgG4 does not activate complement pathways
has reduced effector function relative to other
IgG4 production is driven in part by Th2
The role of IgG4 antibodies in the
IgG4-RSD remains unclear at this time.
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