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ASHWAGANDHA - WITHANIA SOMNIFERA HERB EXTRACT ASHWAGANDHA Ashwagandha which is botanically known as Withania Somnifera has been used as a rejuvenating tonic, an anti-inflammatory agent, aphrodisiac and as an immune booster. It is especially beneficial in stress related disorders such as arthritis, hypertension, diabetes and general debility. It has also shown impressive results when used as stimulants for the immune system. It is considered as an adaptogen that stimulates the immune system and improves the memory. Ashwagandha revitalizes body and decreases untimely fatigue caused due weak body strength. Ashwagandha provides energy and a rejuvenating lift while at the same time offering a calming effect. The name Ashwagandha in sanskrit means the Power of Stallion. Ashwagandha is also known as Indian Ginseng. The chemical components in ashwagandha known as Withanolides are remarkably similar to those found in ginseng. Studies have demonstrated its superiority in stress relieving and stamina boosting abilities when compared to its Korean cousin. Ayurvedic healers have long prescribed the herb to treat exhaustion caused by both physical and mental strain. Recently Ashwagandha has been conclusively found to in crease cognition in patients with brain degenerative diseases like Alzheimers. Benefits of Ashwagandha - Withania Somnifera ADAPTOGEN Ashwagandha has been shown to attenuate the negative effects of chronic stress in rats, including hyperglycemia, glucose intolerance, increase in plasma corticosteroid, levels, gastric ulceration, male sexual dysfunction, cognitive deficits, immunosuppression and mental depression (Bhattacharya & Muruganandam 2003). Animal trials have shown that a withanolide-free hydrosoluble fraction of Withania Somnifera reduces the stress response induced both chemically and physically (Singh et al 2003). Animal studies also suggest an ability to reduce adrenal weight and plasma cortisol levels (Kurandikar et al 1986), thus potentially protecting against the negative effects of elevated cortisol levels in chronic stress and allostasis. NERVOUS SYSTEM ACTIVITY OF ASHWAGANDHA Cognitive enhancement Memory enhancement properties of Ashwagandha has been confirmed by animal studies and appears to be mediated by a cholinergic effect (Dhuley 2001). Increased cortical muscarinic acetylcholine receptor capacity has been observed in animals and humans with extracts of withania (Schliebs et al 1997). Several withanolides exert calcium antagonistic ability, together with anticholinesterase activity, by inhibiting butyrylcholinesterase and acetylcholinesterase enzymes (Choudhary MI et al 2004,2005). The presence of choline in the herb may also contribute to the production of acetylcholine and further increase cholinergic effects. NEUROPROTECTIVE Several animal studies indicate the potential for protection of neurons (Jain et al 2001), including protection from neuronal injury in Parkinson’s disease (Ahmad et al 2005) and promotion of dendrite formation (Tohda et al 2000). One possible explanation is due to the antioxidant properties of withania (Parihar & Hemnani 2003). In animal models of haloperidol-induced dyskinesia (chewing movements, tongue protrusion and buccal tremors), the reported benefits of withania appear to be due to its antioxidant action (Bhattacharya SK et al 2002; Naidu et al 2003). In vitro results suggest that withanolide A is able to reconstruct neuronal networks, including axons, dendrites, pre- and post synapses, in the neurons. Generated with www.html-to-pdf.net Page 1 / 4
ANTIOXIDANT ACTIVITY OF ASHWAGANDHA Ashwagandha exerts an indirect antioxidant action in vivo (Bhattacharya SK et al 1997,Bhattacharya A et al 2001). Daily administration of Ashwagandha root extract increases hepatic glucose-6-phosphatase activity and decreases hepatic lipid peroxidation, most likely by increasing the activity of endogenous antioxidant enzymes (Panda & Kar 1997, 1998, 1999). In vitro Ashwagandha inhibits both the lipid peroxidation and the protein oxidative modification induced by copper (Gupta et al 2003). In animal studies the antioxidant actions have been proposed as a possible mechanism for Ashwagandha preventing the negative effects of stroke induced by middle cerebral artery occlusion (Choudhary G et al 2003). ASHWAGANDHA INCREASES HAEMATOPOIESIS Animal trials indicate the Ashwagandha herb increases hemoglobin and red blood cell levels (Ziauddin et al 1996) and increases haematopoiesis (Aphale et al 1998). The iron content of the herb may further contribute to its role in red blood cell formation. The herb is used in the treatment of iron deficiency anemia due to its effects on haemopoeisis and natural iron content (Aphale et al 1998; Ziauddin et al 1996). This use has been supported by studies showing increased hemoglobin levels in children, induced by withania. ANTI-INFLAMMATORY ACTIVITY OF ASHWAGANDHA The withanolides in Ashwagandha extract (steroidal lactones) are considered to have anti-inflammatory effects (Chevallier 1996). Several withanolides exert selective COX-2 enzyme inhibition (Jayaprakasam & Nair 2003) and withania has been found to decrease alpha-2- macroglobulin, a liver-synthesised plasma protein that increases during inflammation (Anbalagan & Sadique 1985). A reduction in the erythrocyte sedimentation rate has also been noted. Withania is traditionally incorporated into herbal combination formulations for symptom relief in osteoarthritis and rheumatoid arthritis. Its documented anti-inflammatory and antioxidant activities provide support for this use. ANTICANCER (ANTINEOPLASTIC AND CHEMOPREVENTION) PROPERTIES OF ASHWAGANDHA Studies show that Ashwagandha can stimulate the production of cytotoxic T-lymphocytes in vivo and in vitro, and that it may prevent or reduce tumor growth (Davis & Kuttan 2002; Jayaprakasam et al 2003). Withania was found in animal models to prevent skin carcinoma induced by UVB radiation (Mathur et al 2004) and forestomach tumors (Padmavathi et al 2005); Ashwagandha reduces the incidence, number and size of tumors. The withaferin A fraction appears to exert anti-angiogenic activity (Mohan et al 2004) and may be partly responsible for the antineoplastic effects observed in vitro and in vivo studies (Uma Devi 1995, 1996). The antioxidant effects aid in the prevention of DNA damage by mutagens (Khanam & Devi 2005) and this in combination with detoxifying properties, anti-inflammatory and immunomodulatory effects, determined in animal studies, are likely to contribute to its chemopreventive action (Prakash et al 2001, 2002). ASHWAGANDHA AS AN ANXIOLYTIC AND ANTIDEPRESSANT Animal studies have found that withanolides in the Ashwagandha herb exert anxiolytic effects comparable to those of lorazepam, and antidepressant effects comparable to those of the antidepressant drug, imipramine (Bhattacharya SK et al 2000). Home CARDIOPROTECTIVE BENEFITS OF ASHWAGANDHA Shilajit Fulvic Acid Cardioprotective effects of Ashwagandha has been noted in animal studies (Dhuley 2000, Mohanty et al 2004), significantly reducing Shilajit myocardial injury after ischaemia and reperfusion (Gupta SK et al 2004). The alkaloids are considered to be sedative and reduce blood Vidoes pressure and heart rate (Chevallier 1996, Malhotra et al 1965a). The withanolides have a chemical structure similar to cardiac glycosides and Ashwagandha have demonstrated mild ionotropic and chronotropic effects on the heart (Roja et al 1991, Tripathi et al 1996). Antiaging Site Map THYROID MODULATING BENEFITS OF ASHWAGANDHA An in vivo study reported that daily administration of Ashwagandha root extract enhanced serum T4 concentration (Panda & Kar 1998, 1999).Generated with www.html-to-pdf.net Page 2 / 4
ASHWAGANDHA AS A SEXUAL ENHANCER Traditionally used for this purpose, one double-blind clinical trial found that a dose of 3 g taken daily for 1 year improved the sexual performance of 71.4% of healthy aging males (Kupparajan et al 1980). HEPATOPROTECTIVE BENEFITS OF ASHWAGANDHA Animal studies have demonstrated hepatoprotective effects (Bhattacharya A et al 2000, Sudhir et al 1986) and that withania inhibits phase I, and activates phase II and antioxidant enzymes in the liver (Padmavathi et al 2005). What do we offer? In What way our product is different from others? 1. Ours is an ISO 9002 Accredited and Good Manufacturing Procedure (GMP) certified factory. 2. We offer the concentrated extract of Ashwagandha - Withania Somnifera herb. The roots and leaves of Ashwagandha herb is juiced. The juice is flash dried (removing water content at room temperature by creating vacuum). The active concentrated extract of Ashwagandha is encapsulated in soft vegetarian capsules. 3. We offer lowest price guarantee. We operate on a very low or cost to cost margin as we make and ship large number of ASHWAGANDHA HILLS. Our Ashwagandha Hills IS NOT a crushed and dried Ashwagandha powder extruded as tablets or in capsules as offered by most others. Our Ashwagandha Hills is a concentrated extract of Withanolides - the active ingredient of Ashwagandha herb. All commercial transactions done through used by 300 million worldwide Your credit cards and purchases are protected and insured. Order - ASHWAGANDHA HILLS U.S.$12/- 1 Bottle- 1 Months Course. One Time shipping cost: U.S.$6/- You can order 1 bottle or 100 bottles. Shipping will always be same low U.S.$6/- Delivery within 12 days from the date of ordering. Each Bottle contains 60 Capsules of Ashwagandha herb extract. One capsule taken 2 times day. Generated with www.html-to-pdf.net Page 3 / 4
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