Zetterberg plasmatau2013

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Zetterberg plasmatau2013

  1. 1. Plasma tau in acute brain injury andAlzheimer’s diseaseHenrik Zetterberg, MD, PhDProfessor of Neurochemistry
  2. 2. Plasma tau as a biomarker of neuronal injury – the Simoatechnique by QuanterixAEB ~ 0.1 AEB ~ 0.6 AEB ~ 3.0Rissin et al., Anal Chem. 2011Randall et al., Resuscitation, 2013AEB = Average number of Enzymes per BeadHT7Tau5BT2 Detection: β-galCapture: magnetic beads
  3. 3. Plasma tau in cardiac arrest survivorsRandall et al., Resuscitation, 2013
  4. 4. P=.038P=.030Plasma tau in boxers• Study design: 30 amateur (olympic) boxers25 healthy age-matched controlsPlasma samples A) After bout (1-6 days)B) After a rest period (> 2 weeks)• Study design: 30 amateur (olympic) boxers25 healthy age-matched controlsPlasma samples A) After bout (1-6 days)B) After a rest period (> 2 weeks)Neselius et al., Brain Injury, 2013
  5. 5. Plasma tau in concussed hockey players of the Swedish NHLPre-season vs 1 hrUnpaired 2-tail t testP=0.0011Pre-season vs 12 hrUnpaired 2-tail t testP=0.0717Randall et al., unpublished
  6. 6. Plasma tau in concussed hockey players –sample series indicate biphasic releaseRandall et al., unpublished
  7. 7. Plasma tau in Alzheimer’s diseaseZetterberg et al., Alz Res & Ther. 2013
  8. 8. Plasma tau in Alzheimer’s disease – no correlation to CSF…
  9. 9. Hesse et al., JAD 2000CSF tau stays elevated for weeks following acute stroke
  10. 10. …but tau changes fast and is rapidly cleared in bloodInterpretation: different clearance rates of tau in CSF and blood may explainlack of correlation and lack of clear plasma tau changes in AD?
  11. 11. Clinical Neurochemistry LaboratorySahlgrenska University HospitalMölndal/Gothenburg, SwedenAcknowledgementsDave Wilson, Jeff Randalland colleagues atQuanterix Corporation

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