Zetterberg plasmatau2013

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  • 1. Plasma tau in acute brain injury andAlzheimer’s diseaseHenrik Zetterberg, MD, PhDProfessor of Neurochemistry
  • 2. Plasma tau as a biomarker of neuronal injury – the Simoatechnique by QuanterixAEB ~ 0.1 AEB ~ 0.6 AEB ~ 3.0Rissin et al., Anal Chem. 2011Randall et al., Resuscitation, 2013AEB = Average number of Enzymes per BeadHT7Tau5BT2 Detection: β-galCapture: magnetic beads
  • 3. Plasma tau in cardiac arrest survivorsRandall et al., Resuscitation, 2013
  • 4. P=.038P=.030Plasma tau in boxers• Study design: 30 amateur (olympic) boxers25 healthy age-matched controlsPlasma samples A) After bout (1-6 days)B) After a rest period (> 2 weeks)• Study design: 30 amateur (olympic) boxers25 healthy age-matched controlsPlasma samples A) After bout (1-6 days)B) After a rest period (> 2 weeks)Neselius et al., Brain Injury, 2013
  • 5. Plasma tau in concussed hockey players of the Swedish NHLPre-season vs 1 hrUnpaired 2-tail t testP=0.0011Pre-season vs 12 hrUnpaired 2-tail t testP=0.0717Randall et al., unpublished
  • 6. Plasma tau in concussed hockey players –sample series indicate biphasic releaseRandall et al., unpublished
  • 7. Plasma tau in Alzheimer’s diseaseZetterberg et al., Alz Res & Ther. 2013
  • 8. Plasma tau in Alzheimer’s disease – no correlation to CSF…
  • 9. Hesse et al., JAD 2000CSF tau stays elevated for weeks following acute stroke
  • 10. …but tau changes fast and is rapidly cleared in bloodInterpretation: different clearance rates of tau in CSF and blood may explainlack of correlation and lack of clear plasma tau changes in AD?
  • 11. Clinical Neurochemistry LaboratorySahlgrenska University HospitalMölndal/Gothenburg, SwedenAcknowledgementsDave Wilson, Jeff Randalland colleagues atQuanterix Corporation