Trans-synaptic signaling by activity dependent cleavage of                       Neuroligin-1    Rui T. Peixoto, Portia A....
Activity dependent regulation of Neuroligin-1                               GM6001: Broad spectrum Matrix                 ...
NLG1 is cleaved in vivo and in vitro
NLG1 cleavage is regulated by activity and mediated by            NMDAR and CaMK signaling
NLG1-CTF cleavage is regulated by -secretase activity
Activity dependent cleavage of NLG1 is mediated by MMP9
NLG1 ectodomain cleavage occurs in the juxtamembrane region
NLG1 cleavage is regulated locally and occurs in time scales of minutes
Acute NLG1 cleavage reduces mEPSC frequency
NLG1 cleavage modulates release probability
NLG1 cleavage destabilizes pre-synaptic Neurexin-1
Activity dependent NLG1 cleavage in mature and developing circuits
NLG1 cleavage:Homeostatic mechanismSynaptic/circuit remodeling                              Dalva et al. (2007) Nature Neu...
Neural       Development          NLGsASDs                 Epilepsy  Neurodegeneration      Alzheimer          ?
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Rui Peixoto

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Presentation made by Dr. Rui Peixoto, November 1, 2012 on Alzheimer Research Forum (www.alzforum.org)

Published in: Health & Medicine
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Rui Peixoto

  1. 1. Trans-synaptic signaling by activity dependent cleavage of Neuroligin-1 Rui T. Peixoto, Portia A. Kunz, Hyungbae Kwon, Angela M. Mabb, Bernardo L. Sabatini, Benjamin D. Philpot, Michael D. Ehlers Alzheimer Research Forum Webinar 11/1/2012
  2. 2. Activity dependent regulation of Neuroligin-1 GM6001: Broad spectrum Matrix Metalloprotease Inhibitor
  3. 3. NLG1 is cleaved in vivo and in vitro
  4. 4. NLG1 cleavage is regulated by activity and mediated by NMDAR and CaMK signaling
  5. 5. NLG1-CTF cleavage is regulated by -secretase activity
  6. 6. Activity dependent cleavage of NLG1 is mediated by MMP9
  7. 7. NLG1 ectodomain cleavage occurs in the juxtamembrane region
  8. 8. NLG1 cleavage is regulated locally and occurs in time scales of minutes
  9. 9. Acute NLG1 cleavage reduces mEPSC frequency
  10. 10. NLG1 cleavage modulates release probability
  11. 11. NLG1 cleavage destabilizes pre-synaptic Neurexin-1
  12. 12. Activity dependent NLG1 cleavage in mature and developing circuits
  13. 13. NLG1 cleavage:Homeostatic mechanismSynaptic/circuit remodeling Dalva et al. (2007) Nature Neuroscience
  14. 14. Neural Development NLGsASDs Epilepsy Neurodegeneration Alzheimer ?

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