• Share
  • Email
  • Embed
  • Like
  • Save
  • Private Content
Microglial networks in alzheimer’s disease
 

Microglial networks in alzheimer’s disease

on

  • 2,567 views

 

Statistics

Views

Total Views
2,567
Views on SlideShare
640
Embed Views
1,927

Actions

Likes
0
Downloads
12
Comments
0

8 Embeds 1,927

http://www.alzforum.org 1790
http://devlocal.alzforum.com 51
http://alzforum.org 50
http://brfroot.prod.acquia-sites.com 29
http://legacy.alzforum.org 4
http://10.170.30.107 1
http://translate.googleusercontent.com 1
http://brfrootstg.prod.acquia-sites.com 1
More...

Accessibility

Upload Details

Uploaded via as Adobe PDF

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

    Microglial networks in alzheimer’s disease Microglial networks in alzheimer’s disease Presentation Transcript

    • Microglial Networks inAlzheimer’s diseaseJohn Hardy j.hardy@ucl.ac.ukUCL Institute of Neurology UnitedKingdom
    • Risk Loci for Alzheimer’s Disease (~6000Samples: General Lessons hold true as Samplenumbers increase)BIN1, bridging integrator 1; OR, odds ratio.Harold D, et al. Nat Genet. 2009;41:1088-1093; Hollingworth P, et al. Nat Genet. 2011;43:429-435; Lambert JC, et al. Nat Genet.2009;41:1094-1099.Apolipoprotein E4 OR ~4Cholesterol metabolism: coding andexpressionCLU OR ~1.4Cholesterol metabolism: complementcascade—not coding, not simpleexpressionPICALM OR ~1.4 Endosomal vesicle recycling? Not codingABCA7 OR ~1.3Cholesterol metabolism: not known butGly1527Ala is possibleCR1 OR ~1.4Complement cascade: verycomplicated—probably sequence andexpressionBIN1 OR ~1.2 Endosomal vesicle recycling? Not codingMS4AE OR ~1.2 Cell surface protein: not coding
    • Normal Functioning CR1 and TREM2Promote Neuroprotection by Microglia
    • Loss of Function of CR1 and TREM2Promotes Inflammation and NeurotoxicityTNFa, tumor necrosis factor alpha.
    • An introduction to the UK Brain ExpressionConsortium (UKBEC) data setFrontal cortex (n=83)Temporal cortex (n=72)Occipital cortex (n=77)Hippocampus (n=86)Intralobular white matter (n=83)Cerebellar cortex (n=76)Thalamus (n=81)Putamen (n=77)Substantia nigra (n=65)Medulla (inf. olivary nuc, n=88)GENOME-WIDEEXPRESSIONFrom EACH brainsample 10 brain regionsAffy HumanExon 1.0 STarraysCONTROLHUMANBRAINSN = 134ONLY samples coming from a single brain bank, MRC Sudden Death Brain Bank
    • TREM2 is a “hub” gene within its module inmultiple brain regions including hippocampus(Forabosco et al. NBA June 2013)Hippocampus