Alzforum webinar m heneka 20 03 2013

Uploaded on

Presentation made by Dr. Michael Heneka at the Alzheimer Research Forum Live Webinar of March 20, 2013 -

Presentation made by Dr. Michael Heneka at the Alzheimer Research Forum Live Webinar of March 20, 2013 -

  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Be the first to comment
    Be the first to like this
No Downloads


Total Views
On Slideshare
From Embeds
Number of Embeds



Embeds 0

No embeds

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

    No notes for slide


  • 1. Impact of Locus Coeruleus Degeneration in Alzheimer´s DiseaseMichael T. HenekaClincal Neuroscience Unit, University of Bonn andGerman center for Neurodegenerative DiseaseAlzforum, 20.03.2013
  • 2. Anatomy and function
  • 3. LC pathology in ADCON AD
  • 4. Aggravating spatial memory dysfunction 6 *** 3.5 ## *** reference memory errors working memory errors 3.0 ### 4 ** 2.5 2.0 ** 1.5 2 1.0 0.5 0 0.0 on tg n on 4 4 4 4 tg n sp sp sp sp o o t-c -c t-c -c t-d -d t-d -d tg tg w w w wdsp4 – induced LC degeneration in APP23 mice Heneka et al. J.Neurosci. , 2006
  • 5. Social memory dysfunction• Mice were habituated to the apparatus for 4 days.• A male mouse was presented for 5 minutes at the test day.• One hour later the same animal was represented.
  • 6. Ear2 ko (LC loss) vs DBH ko (NA loss) Hammerschmidt et al. Biol.Psychiatry, 2012
  • 7. Effects on synaptic plasticity
  • 8. L-threo-DOPS restores NE in the cortex and hippocampus Thomas et al. J.Neurochem. 1998 Heneka et al. PNAS 2010
  • 9. Behavioural improvement by L-threo DOPS
  • 10. Modulation of the synaptosome
  • 11. Partial protection of β-CaMKIIpThr286
  • 12. SummaryLocus ceruleus degeneration represents an early event in ADLoss of LC and NE in LC projection areas may cause early memorydysfunctionIF EE mediated effects are mediated by LC derived NA – can they beexpected in AD patients?Could EE/cognitive strategies slow disease progression more effectivelywhen patients receive NA substitution by L-threo DOPS?What´s the cause of LC degeneration and does EE delay/prevent it?