Allergy

Allergy Degranulation Process

Allergy
Activated mast cells go through a process called degranulation. They release histamine and other chemicals causing inflammation.

Allergy
The antigen floats around the body …

Allergy
IgE antibod ies find allergen and attach themselves to it.

Allergy
IgE binds to IgE receptors on surface of mast cells (a type of immune cell)
This is a kind of FC receptor.

Allergy
Stored mediators (4) such as histamine, proteases, chemokines and heparine are released from granules (5)

Allergy
N ewly formed mediators also released (prostaglandins, leukotrienes, thromboxanes amd PAF)

Allergy
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Material from Wikipedia
Image by Paweł Kuźniar

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