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Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
Pr bouchard
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Pr bouchard

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  • 1. Charles Edouard Brown Sequard (1817- 1894)
  • 2. Science 1997
  • 3. & GH
  • 4. GH-IGF1-Insulin <ul><li>1- Les données de la recherche sont sans equivoque. </li></ul>
  • 5. INSULIN / IGFs Signaling
  • 6. INSULIN / IGFs Signaling KO GH KO GHRH KO GHR KO KO IGF1 KO IGF1-R KO IRS 1 &amp; 2, PI3 K Yeasts, caenorhabditis elegans, insects, mice &amp; centenarial model
  • 7. Endocrine Reviews 2011
  • 8. Des taux bas d ’IGF1 sont associés à une longévité accrue <ul><li>Déficit en GH </li></ul><ul><li>KO des récepteurs de la GH </li></ul><ul><li>KO des récepteurs de l ’IGF1(Bartke A Cur Top Dev Biol 63:189, 2004) </li></ul>
  • 9. &nbsp;
  • 10. &nbsp;
  • 11. &nbsp;
  • 12. &nbsp;
  • 13. &nbsp;
  • 14. + 18 %
  • 15. &nbsp;
  • 16. GH-IGF1-Insulin <ul><li>2- Chez l’homme… </li></ul>
  • 17. &nbsp;
  • 18. Endocrine Reviews 2010, 31: 301-342.
  • 19. &nbsp;
  • 20. JCEM 18: 901- 903, 1958 NATURE 1979
  • 21. There is now a substantial body of evidence that indicates that GH Replacement Therapy has a beneficial effect upon many parameters: Body composition improves, lean mass increases, and fat mass decreases sgnificantly. <ul><li>Fasting lipid profile improves with reduction on total cholesterol, LDL </li></ul><ul><li>while HDL increases. </li></ul><ul><li>GHT improves endothelial function as well as the markers of inflammation </li></ul><ul><li>- Carotid IMT also demonstrates a significant improvement during therapy </li></ul>
  • 22. Swerdlow AJ, Higgins CD, Adlard P, Preece MA 2002 Risk of cancer in patients treated with 17 human pituitary growth hormone in the UK, 1959-85: a cohort study. Lancet 360:273-277 <ul><li>Insulin resistance is Increased </li></ul><ul><li>There is no data demonstrating </li></ul><ul><li>that GHT reduces cardiovascular mortality </li></ul><ul><li>in hypopituitary adults </li></ul><ul><li>- In addition: cancer risk may be increased </li></ul>HOWEVER
  • 23. JCEM 2012 SAGhE : Safety and Appropriateness of Growth hormone treatments in Europe
  • 24. &nbsp;
  • 25. &nbsp;
  • 26. &nbsp;
  • 27. &nbsp;
  • 28. &nbsp;
  • 29. Les Fondamentaux <ul><li>« Apprends d’hier, vis pour aujourd’hui, espère pour demain. </li></ul><ul><li>L’important est de ne jamais arrêter de poser des question. » </li></ul><ul><li>Albert Einstein </li></ul>
  • 30. www.ice-ece2012.com

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