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Breast Cancer VS Coffee

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Presentation Discuss affect of coffee consumption against breast cancer

Presentation Discuss affect of coffee consumption against breast cancer

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  • 1. Breast cancer VS Coffee*** Supervised by : Mrs. Dara Al Disi Presented by : Samar Al Dhamadi
  • 2. Introduction ♀ What is cancer ? Cancer is the name given to a large number of diseases. ♀ The most common form of cancer among women . ♀ 2nd most common cause of cancer related mortality.
  • 3. 12 signs of breast cancer : 1. Hardening. 2. Growing vein. 3. Redness or hotness. 4. Skin erosion/rash. 5. Visible bump. 6. Puckering or dimpling. 7. Retracted nipple. 8. New asymmetry. 9. Change in shape or size. 10. Unusual fluid. 11. Invisible lump. 12. Skin that looks like an orange.
  • 4. What does breast cancer look like ?
  • 5. Rational ♀1/3 of women with breast cancer die from breast cancer . ♀Coffee is among the most widely consumed beverages in the world and is a major source of dietary caffeine.
  • 6. Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers. st
  • 7. Objectives of the study * ♀ Over the last 2 decades, coffee and caffeine have been studied with regard to their potential role in breast cancer etiology. ♀ A number of animal studies have reported caffeine to both stimulate and to suppress breast tumors, depending upon the species and the phase of administration. *Wiley-Liss , International Journal of Cancer 2006 http://www3.interscience.wiley.com/journal/110572608/abstract?CRETRY=1&SRETRY=0
  • 8. Objectives of the study * Coffee consumption (or caffeine intake) has been directly associated with : ♀ Plasma estradiol . ♀ Estrone . ♀ Sex hormone-binding globulin levels . ♀ Inversely testosterone. Coffee consumption also induces cell differentiation4 and may inhibit mitosis. *Wiley-Liss , International Journal of Cancer 2006 http://www3.interscience.wiley.com/journal/110572608/abstract?CRETRY=1&SRETRY=0
  • 9. Material and method * ♀ Eligible study subjects included women who were currently alive and were known to be carriers of deleterious mutations of the BRCA1 or BRCA2 gene. ♀ These women were identified from 40 participating clinical cancer genetics centers in 4 countries and were participants in prior and ongoing clinical research protocols at the host institutions. *Wiley-Liss , International Journal of Cancer 2006 http://www3.interscience.wiley.com/journal/110572608/abstract?CRETRY=1&SRETRY=0
  • 10. Material and method * ♀Total of 2,474 eligible women, including 1,371 women with a history of invasive breast cancer diagnosed between 1970 and 2002 (potential cases) and 1,103 women who never had breast cancer and who were carriers of a mutation in the BRCA1 or BRCA2 gene (potential controls). *Wiley-Liss , International Journal of Cancer 2006 http://www3.interscience.wiley.com/journal/110572608/abstract?CRETRY=1&SRETRY=0
  • 11. Material and method * ♀Control subjects were women who never had breast cancer but were known to be carriers of a mutation in the BRCA1 or BRCA2 gene. ♀A single control subject was selected for each case subject matched according to mutation in the same gene (BRCA1 or BRCA2), year of birth . *Wiley-Liss , International Journal of Cancer 2006 http://www3.interscience.wiley.com/journal/110572608/abstract?CRETRY=1&SRETRY=0
  • 12. Material and method * ♀A diagnosis of ovarian or other form of cancer in the control had to be after the year of diagnosis of the matched case subject. ♀The date of interview of the controls was after the breast cancer diagnosis of the case. *Wiley-Liss , International Journal of Cancer 2006 http://www3.interscience.wiley.com/journal/110572608/abstract?CRETRY=1&SRETRY=0
  • 13. Material and method * ♀ A total of 845 matched case-control pairs were generated for the analysis, including 652 pairs with BRCA1 mutations and 193 pairs with BRCA2 mutations. ♀ The questionnaires were completed between 1977 and 2002. For the cases, an average of 7.8 years had elapsed from the date of diagnosis of breast cancer until the date the questionnaire was completed (range 0–42 years). *Wiley-Liss , International Journal of Cancer 2006 http://www3.interscience.wiley.com/journal/110572608/abstract?CRETRY=1&SRETRY=0
  • 14. Material and method * Case and control subjects at all participating centers completed a standardized questionnaire that asked for all relevant information regarding: ♀ Family history. ♀ Reproductive and medical histories . ♀ Selected lifestyle factors ; smoking history. ♀ Use of oral contraceptives. *Wiley-Liss , International Journal of Cancer 2006 http://www3.interscience.wiley.com/journal/110572608/abstract?CRETRY=1&SRETRY=0
  • 15. Material and method * ♀ Additional variables ♀ Demography. ♀ Ethnicity. ♀ Alcohol and coffee consumption. Questionnaire was completed at the time blood was drawn for genetic testing or within a year of receiving the test result. *Wiley-Liss , International Journal of Cancer 2006 http://www3.interscience.wiley.com/journal/110572608/abstract?CRETRY=1&SRETRY=0
  • 16. Material and method * The study subjects were asked : ♀ Ever consumed coffee. ♀ Currently consumed coffee. ♀ At what age they 1st began coffee consumption. ♀ At what age they stopped drinking coffee. ♀ Average daily coffee consumption over this period. Questions were asked separately for caffeinated and decaffeinated coffee. *Wiley-Liss , International Journal of Cancer 2006 http://www3.interscience.wiley.com/journal/110572608/abstract?CRETRY=1&SRETRY=0
  • 17. Result * ♀The protective effect was significant for women diagnosed ⬇ the age of 50, and a trend was apparent. ♀ A significant risk reduction was not seen for women diagnosed with breast cancer after age 50, but this study group was small. *Wiley-Liss , International Journal of Cancer 2006 http://www3.interscience.wiley.com/journal/110572608/abstract?CRETRY=1&SRETRY=0
  • 18. Discussion * ♀ Study indicates that women with BRCA1 or BRCA2 mutations who consumed at least 6 cups of coffee per day appeared to have a statistically significant reduction in breast cancer risk, relative to BRCA mutation carriers who have never drunk coffee. ♀ The stronger effect observed among BRCA1 mutation carriers is likely attributed to a larger sample size. There was no clear protective effect of coffee consumed at levels less than this. *Wiley-Liss , International Journal of Cancer 2006 http://www3.interscience.wiley.com/journal/110572608/abstract?CRETRY=1&SRETRY=0
  • 19. Discussion * ♀1st study to our knowledge of coffee consumption and breast cancer risk in BRCA mutation carriers—previous studies have been in the nontested population (which are mostly noncarriers). *Wiley-Liss , International Journal of Cancer 2006 http://www3.interscience.wiley.com/journal/110572608/abstract?CRETRY=1&SRETRY=0
  • 20. Discussion * ♀The protective effect associated with coffee consumption may be due to the ability of caffeine to influence estrogen metabolism. *Wiley-Liss , International Journal of Cancer 2006 http://www3.interscience.wiley.com/journal/110572608/abstract?CRETRY=1&SRETRY=0
  • 21. Conclusion * ♀findings suggest that relatively ⬆ coffee consumption may ⬇ breast cancer risk among women with BRCA1 and/or BRCA2 gene mutations. * *Wiley-Liss , International Journal of Cancer 2006 http://www3.interscience.wiley.com/journal/110572608/abstract?CRETRY=1&SRETRY=0
  • 22. Caffeine consumption and risk of breast cancer in a large prospective cohort of women . nd
  • 23. Objective ** ♀Given the ⬆ prevalence of consumption of caffeinated beverages and foods, an association between caffeine intake and risk of breast cancer would be of great public health importance. **K. Ishitani,. J Clin Oncol 26: 2008 http://www.asco.org/ASCO/Abstracts+&+Virtual+Meeting/Abstracts?&vmview=abst_detail_view&confID=55&abstractID=30195
  • 24. Material and method ** ♀ Detailed dietary information was obtained by the food frequency questionnaire at baseline (1992-1995) among 38,453 women who were aged 45 years or older and free of cancer and cardiovascular disease. ♀ An average of 10 years of follow-up, we identified 1188 invasive breast cancer cases. **K. Ishitani,. J Clin Oncol 26: 2008 http://www.asco.org/ASCO/Abstracts+&+Virtual+Meeting/Abstracts?&vmview=abst_detail_view&confID=55&abstractID=30195
  • 25. Results ** Consumption of caffeine was Not statistically significantly associated with overall risk of breast cancer. **K. Ishitani,. J Clin Oncol 26: 2008 http://www.asco.org/ASCO/Abstracts+&+Virtual+Meeting/Abstracts?&vmview=abst_detail_view&confID=55&abstractID=30195
  • 26. Conclusion ** No Overall association between consumption of caffeine and caffeinated beverages & foods and risk of breast cancer. ** Caffeine consumption and risk of breast cancer in a large prospective cohort of women
  • 27. Recommendation ♀ Drinking 1 – 3 cops of coffee daily can ⬇ breast cancer risk among women with BRCA1 and/or BRCA2 gene mutations. ♀ Coffee dose not increase risk of breast cancer .
  • 28. References * Wiley-Liss , Inc. Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers. Int. J. Cancer. 2006; 118: 103–107. Site : International Journal of Cancer : http://www3.interscience.wiley.com/journal/110572608/abstract?CRETRY=1&SRETRY=0 ** K. Ishitani, J. Lin, J. E. Manson, J. E. Buring, S. M. Zhang . Caffeine consumption and risk of breast cancer in a large prospective cohort of women . J Clin Oncol 26: 2008 (May 20 suppl; abstr 11060) Site : American Society of clinical oncology ASCO , 2008 ASCO Annual Meeting http://www.asco.org/ASCO/Abstracts+&+Virtual+Meeting/Abstracts?&vmview=abst_detail_view&confID=55&abstractID =30195 *** Handbook of Nutraceuticals and functional foods , 2nd edition ,
  • 29. Thank you 
  • 30. Health Education
  • 31. Screening time
  • 32. Breast Self Exam
  • 33. Biopsy :
  • 34. Find Early can cure rates exceeds 90 %

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