P R E P A R A T I O N O F S U P P O S I T O R I E S

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P R E P A R A T I O N O F S U P P O S I T O R I E S

  1. 1. PREPARATION OF SUPPOSITORIES BY: Daniel Thomas A. Berberabe
  2. 2. How to prepare suppositories?? <ul><li>Molding from a melt </li></ul><ul><li>2. Compression </li></ul><ul><li>3. Hand rolling and Shaping </li></ul>
  3. 3. Preparation by Molding <ul><li>STEPS! </li></ul><ul><li>Melting the base </li></ul><ul><li>Incorporating any required medicaments </li></ul><ul><li>Pouring the melt into molds </li></ul><ul><li>Allowing the melt to cool and congeal into suppositories </li></ul><ul><li>Removing the formed suppositories from the mold </li></ul>
  4. 4. Preparation by Molding <ul><li>Cocoa butter , Glycerinated gelatin , Polyethylene glycol and most other bases are suitable for MOLDING </li></ul>
  5. 5. What are Suppository Molds? <ul><li>Molds are use to produce individual or large number of suppositories of various shapes and sizes. </li></ul>
  6. 6. Suppository Mold
  7. 7. Plastic Molds <ul><li>Individual plastic molds may be used to form a single suppository </li></ul>
  8. 8. Industrial Molds <ul><li>Produces hundreds of suppositories from a single batch </li></ul>
  9. 9. Molds <ul><li>Care must be exercised in cleaning molds. </li></ul><ul><li>Any scratches on the molding surface will take away from the desired smoothness of the suppositories </li></ul>
  10. 10. Temporary Molds <ul><li>Pressing heavy aluminum foil about an object having the shape of the desired suppository. </li></ul>
  11. 11. Tips! <ul><li>Round pencils or pens may be used to form molds for rectal suppositories. </li></ul><ul><li>Stirring rods for urethral suppositories </li></ul><ul><li>Any cone-shaped object for vaginal suppositories </li></ul>
  12. 12. Lubrication of the Mold <ul><li>Lubrication is required before the melt is poured to facilitate clean and easy removal of the molded suppositories </li></ul>
  13. 13. Lubrication of the Mold <ul><li>Lubrication is seldom necessary when the base is cocoa butter or polyethylene glycol. </li></ul><ul><li>Lubrication is necessary with glycerinated gelatin. </li></ul><ul><li>Mineral Oil applied on the molding surfaces is enough to lubricate it. </li></ul>
  14. 14. Calibration of the Mold <ul><li>The first step is to prepare molded suppositories from base material alone </li></ul><ul><li>The suppository's combined and average weight is recorded. </li></ul>
  15. 15. Calibration of the Mold <ul><li>To determine the volume of the mold, the suppositories are melted in a calibrated beaker, and the volume of the melt is determined </li></ul>
  16. 16. How to determine the amount of base required? <ul><li>The physician indicates the amount of medicinal substance desired in a suppository </li></ul><ul><li>The pharmacist determines the amount of base in a suppository </li></ul>
  17. 17. Three methods in determining the amount of base required <ul><li>Volume of the drug substance subtracted to the total volume of the mold = Volume of the base </li></ul><ul><li>Dissolve the active ingredient in a portion of the melted base and add the remaining base to fill one cavity </li></ul>
  18. 18. Three methods in determining the amount of base required <ul><li>3. Place all the required medicaments for the preparation of the total number of suppositories in a calibrated beaker. Incorporate the drug substance with a portion of the melt base. Add enough melted base to fill all the required volume of the molds </li></ul>
  19. 19. Preparing and Pouring the Melt <ul><li>The weighed suppository based material is melted in a water bath. </li></ul><ul><li>Prevent undissolved or suspended material to settle by stirring </li></ul>
  20. 20. Preparing and Pouring the Melt <ul><li>Small quantity of silica gel can be incorporated to keep the active drug suspended </li></ul><ul><li>Pour excessively in each opening to ensure a completely filled mold upon congealing </li></ul>
  21. 21. Preparation by Compression <ul><li>Forcing the mixed mass of the base and the medicaments into special molds using suppository making machines </li></ul>
  22. 22. Suppository-making machine
  23. 23. Compression <ul><li>Compression is especially suited for making suppositories that contain heat-labile medicinal substances or substances that are insoluble in the base </li></ul>
  24. 24. Disadvantages of Compression Method <ul><li>Suppository Machine is required </li></ul><ul><li>There are some limitation as to shapes of suppositories that can be made </li></ul>
  25. 25. Preparation by Hand Rolling and Shaping <ul><li>A historic part of the art of pharmacist </li></ul><ul><li>With ready availability of suppository molds, there is little requirement for pharmacist to shape suppositories by hand </li></ul>

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