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Pemphigus vulgaris
 

Pemphigus vulgaris

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UST - Touch Of Creativity

UST - Touch Of Creativity
Oral Medicine
pemphigus vulgaris
By: Dr.Shaima Alkasem

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    Pemphigus vulgaris Pemphigus vulgaris Presentation Transcript

    • Definition : An autoimmune vesiculobullous blistering disease characterized by intra-epithelial blister formation.
    • Aetiopathogenesis : Circulating autoantibodies of (IgG) type target the desmosomal complexes, Desmoglein 3 and 1 .
    • Epidemiology : - Equal Incidence rate in both genders . - Most patient presenting during the 4th and 5th decades of life . - Genetic and ethnic factors: Ashkenazic Jews and Mediterranean patients .
    • Clinical features : - Painful ulcers . - Intra oral: Bullae apprear on any part of oral mucosa and becomes ulcers, fig (1-2) . - Extra oral : blisters appear on skin of face, back or chest, fig(3) . - Positive Nikolsky`s sign .
    • Clinical features : Fig(1): ulcers in lower lip
    • Clinical features : Fig(2): ulcers in buccal mucosa
    • Clinical features : Fig(3): ulcers in skin of back
    • Diagnosis : - Direct Immunofluorescence fig(4) . - Indirect Immunofluorescence .
    • Diagnosis : fig(4): Direct Immunofluorescence .
    • Differential Diagnosis : - Mucous membrane pemphigoid . - Erythema Multiforme . - Paraneoplastic pemphigus . - Pemphigus vegetans .
    • Treatment : Based on disease severity : * Mild : - Topical corticosteroids .
    • Treatment : * Moderate to sever : systemic agents include : - prednisone . - mycophenolate mofetil . - azathioprine . - cyclosporine .