0
Human  Metapneumovirus Prof. Dr. Saad S Al Ani Senior Pediatric Consultant Head of Pediatric Department Khorfakkan Hospita...
Human Metapneumovirus (hMPV) <ul><li>hMPV is associated with a substantial number of upper respiratory infections  ( URI )...
Cont. <ul><li>hMPV was first described in 2001 by Dutch investigators. (1)  </li></ul><ul><li>It is a member of the  Pneum...
Cont. <ul><li>It is pleomorphic with a lipid envelope. </li></ul><ul><li>Single-stranded RNA genome   </li></ul>( 1)van de...
Cont. <ul><li>These illnesses are neither clinically nor radiographically distinct from the same clinical syndromes caused...
Cont. <ul><li>Clinical manifestations of hMPV infection  are generally similar to those caused by other respiratory viruse...
Cont. <ul><li>Hospitalizations occur more common in children or adults with underlying conditions such as: </li></ul><ul><...
Bar in the image represents 10 nm.   Glycoprotein spikes are visible in viral membrane and extruded nucleocapsid is visibl...
Epidemiology <ul><li>Annual epidemics during the  late winter  and  early spring  months in temperate locations </li></ul>...
Cont. <ul><li>Peak age of hospitalization for hMPV occurs between  6 and 12 months  of age  </li></ul><ul><li>hMPV - infec...
Clinical Manifestations <ul><li>* Upper respiratory tract symptoms, including: </li></ul><ul><li>- Rhinorrhea </li></ul><u...
Cont. <ul><li>*  Lower respiratory tract syndromes most frequently associated with hMPV infection are: </li></ul><ul><li>-...
<ul><li>Infancy </li></ul><ul><li>1.Bronchiolitis </li></ul><ul><li>2.Pneumonia  </li></ul><ul><li>3.Croup  </li></ul><ul>...
Cont. <ul><li>Older children  / adults </li></ul><ul><li>1. Croup </li></ul><ul><li>   2. Laryngitis  </li></ul><ul><li>  ...
Diagnosis <ul><li>There is no commercially available rapid antigen test for hMPV  </li></ul><ul><li>In general, reliable d...
Treatment  <ul><li>The majority of children infected with hMPV can be managed at home with supportive care. </li></ul><ul>...
Prevention <ul><li>Recombinant hMPV strains that lack various genes </li></ul><ul><li>Highly immunogenic, inducing neutral...
<ul><li>Thank you </li></ul>
Upcoming SlideShare
Loading in...5
×

Human metapneumovirus

2,144

Published on

What is human metapneumovirus ,features,presentation ,diagnosis ,treatment and prevention

Published in: Health & Medicine
0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total Views
2,144
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
45
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide

Transcript of "Human metapneumovirus"

  1. 1. Human Metapneumovirus Prof. Dr. Saad S Al Ani Senior Pediatric Consultant Head of Pediatric Department Khorfakkan Hospital Sharjah ,UAE [email_address]
  2. 2. Human Metapneumovirus (hMPV) <ul><li>hMPV is associated with a substantial number of upper respiratory infections ( URI ) and episodes of acute otitis media ( AOM ). </li></ul>Williams JV, Wang CK, Yang CF, et al :  The role of human metapneumovirus in upper respiratory tract infections in children: a 20-year experience.   J Infect Dis   2006; 193:387-395
  3. 3. Cont. <ul><li>hMPV was first described in 2001 by Dutch investigators. (1) </li></ul><ul><li>It is a member of the Pneumovirus subfamily of the Paramyxoviridae that includes respiratory syncytial virus (RSV) . </li></ul>( 1)van den Hoogen BG, de Jong JC, Groen J, et al: A newly discovered human pneumovirus isolated from young children with respiratory tract disease.   Nat Med  2001; 7:719-724.
  4. 4. Cont. <ul><li>It is pleomorphic with a lipid envelope. </li></ul><ul><li>Single-stranded RNA genome </li></ul>( 1)van den Hoogen BG, de Jong JC, Groen J, et al: A newly discovered human pneumovirus isolated from young children with respiratory tract disease.   Nat Med  2001; 7:719-724.
  5. 5. Cont. <ul><li>These illnesses are neither clinically nor radiographically distinct from the same clinical syndromes caused by other common respiratory viruses . </li></ul><ul><li>hMPV can cause severe infections in immunocompromised hosts </li></ul><ul><li>Transmission of hMPV likely occurs via respiratory droplets and secretions, similar to RSV </li></ul>van den Hoogen BG, de Jong JC, Groen J, et al :  A newly discovered human pneumovirus isolated from young children with respiratory tract disease .   Nat Med   2001; 7:719-724.
  6. 6. Cont. <ul><li>Clinical manifestations of hMPV infection are generally similar to those caused by other respiratory viruses and include: </li></ul><ul><li>* Bronchiolitis </li></ul><ul><li>* Croup </li></ul><ul><li>* Pneumonia </li></ul><ul><li>* Asthma exacerbation. </li></ul>Osterhaus A, Fouchier R :  Human metapneumovirus in the community.   Lancet   2003; 361:890-891.
  7. 7. Cont. <ul><li>Hospitalizations occur more common in children or adults with underlying conditions such as: </li></ul><ul><li>* Prematurety </li></ul><ul><li>* Asthma </li></ul><ul><li>* Immune compromisation </li></ul><ul><li>* Cardiopulmonary disease s . </li></ul>Williams JV, Tollefson SJ, Heymann PW, et al :  Human metapneumovirus infection in children hospitalized for wheezing.   J Allergy Clin Immunol   2005; 115:1311-1312
  8. 8. Bar in the image represents 10 nm. Glycoprotein spikes are visible in viral membrane and extruded nucleocapsid is visible below Human Metapneumovirus
  9. 9. Epidemiology <ul><li>Annual epidemics during the late winter and early spring months in temperate locations </li></ul><ul><li>The peak incidence of hMPV usually occurs 1 to 2 months later than the peak of RSV . </li></ul><ul><li>The percentage of hMPV detection varies from 6% to 15% among patients with acute respiratory tract infection </li></ul><ul><li>van den Hoogen BG, van Doornum GJ, Fockens JC, et al: Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients.   J Infect Dis   2003; 188:1571-1577. </li></ul><ul><li>Esper F, Martinello RA, Boucher D, et al: A 1-year experience with human metapneumovirus in children aged < 5 years. J Infect Dis 2004; 189:1388-1396 </li></ul><ul><li>Osterhaus A, Fouchier R: Human metapneumovirus in the community.   Lancet   2003; 361:890-891 . </li></ul>
  10. 10. Cont. <ul><li>Peak age of hospitalization for hMPV occurs between 6 and 12 months of age </li></ul><ul><li>hMPV - infected children have higher rates of underlying disease than RSV - infected children . </li></ul><ul><li>Thanasugarn W, Samransamruajkit R, Vanapongtipagorn P, et al :  Human metapneumovirus infection in Thai children.   Scand J Infect Dis   2003; 35:754-756 </li></ul><ul><li>Bosis S, Esposito S, Niesters HG, et al :  Impact of human metapneumovirus in childhood: comparison with respiratory syncytial virus and influenza viruses.   J Med Virol   2005; 75:101-104. </li></ul>
  11. 11. Clinical Manifestations <ul><li>* Upper respiratory tract symptoms, including: </li></ul><ul><li>- Rhinorrhea </li></ul><ul><li>- Cough </li></ul><ul><li>- Fever . </li></ul><ul><li>- Conjunctivitis </li></ul><ul><li>- Vomiting, Diarrhea , Rash are occasionally </li></ul><ul><li>reported </li></ul>Noyola DE, Alpuche - Solis AG, Herrera - Diaz A, et al :  Human metapneumovirus infections in Mexico: epidemiological and clinical characteristics.   J Med Microbiol   2005; 54:969-974
  12. 12. Cont. <ul><li>* Lower respiratory tract syndromes most frequently associated with hMPV infection are: </li></ul><ul><li>- bronchiolitis </li></ul><ul><li>- croup </li></ul><ul><li>- pneumonia </li></ul><ul><li>- asthma exacerbation . </li></ul>Noyola DE, Alpuche - Solis AG, Herrera - Diaz A, et al :  Human metapneumovirus infections in Mexico: epidemiological and clinical characteristics.   J Med Microbiol   2005; 54:969-974
  13. 13. <ul><li>Infancy </li></ul><ul><li>1.Bronchiolitis </li></ul><ul><li>2.Pneumonia  </li></ul><ul><li>3.Croup  </li></ul><ul><li>4.Exacerbation of asthma  </li></ul><ul><li>5. Upper respiratory tract infection  </li></ul><ul><li>6.Acute otitis media </li></ul>Clinical Manifestations at Various Ages Takao S, Shimozono H, Kashiwa H, et al :  Clinical study of pediatric cases of acute respiratory diseases associated with human metapneumovirus in Japan.   Jpn J Infect Dis   2003; 56:127-129.
  14. 14. Cont. <ul><li>Older children / adults </li></ul><ul><li>1. Croup </li></ul><ul><li>  2. Laryngitis  </li></ul><ul><li>  3. Bronchitis  </li></ul><ul><li>  4. Asthma exacerbation  </li></ul><ul><li>  5. Pneumonia (elderly)  </li></ul><ul><li>  6.Exacerbation of chronic obstructive pulmonary </li></ul><ul><li>disease (elderly) </li></ul>Takao S, Shimozono H, Kashiwa H, et al :  Clinical study of pediatric cases of acute respiratory diseases associated with human metapneumovirus in Japan.   Jpn J Infect Dis   2003; 56:127-129.
  15. 15. Diagnosis <ul><li>There is no commercially available rapid antigen test for hMPV </li></ul><ul><li>In general, reliable diagnosis of hMPV currently depends on molecular techniques based on standard or real-time RT-PCR assays. </li></ul><ul><li>Bellau - Pujol S, Vabret A, Legrand L, et al :  Development of three multiplex RT - PCR assays for the detection of 12 respiratory RNA viruses .   J Virol Methods   2005; 126:53-63. </li></ul><ul><li>Lopez - Huertas MR, Casas I, Acosta - Herrera B, et al :  Two RT - PCR based assays to detect human metapneumovirus in nasopharyngeal aspirates.   J Virol Methods   2005; 129:1-7. </li></ul>
  16. 16. Treatment <ul><li>The majority of children infected with hMPV can be managed at home with supportive care. </li></ul><ul><li>For hospitalized infants and children the primary therapies are supplementary oxygen and intravenous hydration. </li></ul><ul><li>Bronchodilators and corticosteroids ? </li></ul><ul><li>Ribavirin and polyclonal human immunoglobulin?(1) </li></ul>(1)Hamelin ME, Prince GA, Boivin G :  Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection.   Antimicrob Agents Chemother   2006; 50:774-777.
  17. 17. Prevention <ul><li>Recombinant hMPV strains that lack various genes </li></ul><ul><li>Highly immunogenic, inducing neutralizing antibodies and protection against challenge with wild-type hMPV. </li></ul><ul><li>Several potential vaccine candidates are in development within 3 years of the discovery of hMPV, </li></ul><ul><li>Tang RS, Mahmood K, Macphail M, et al :  A host - range restricted parainfluenza virus type 3 ( PIV3 ) expressing the human metapneumovirus (hMPV) fusion protein elicits protective immunity in African green monkeys.   Vaccine   2005; 23:1657-1667. </li></ul><ul><li>Biacchesi S, Skiadopoulos MH, Yang L, et al: Recombinant human metapneumovirus lacking the small hydrophobic SH and/or attachment G glycoprotein: deletion of G yields a promising vaccine candidate. J Virol 2004; 78:12877-12887 . </li></ul>
  18. 18. <ul><li>Thank you </li></ul>
  1. A particular slide catching your eye?

    Clipping is a handy way to collect important slides you want to go back to later.

×