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Types of Bioreactors / Fermenters
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Types of Bioreactors / Fermenters

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The heart of the fermentation or bioprocess technology is the Fermentor or Bioreactor. A bioreactor is basically a device in which the organisms are cultivated to form the desired products. it is a ...

The heart of the fermentation or bioprocess technology is the Fermentor or Bioreactor. A bioreactor is basically a device in which the organisms are cultivated to form the desired products. it is a containment system designed to give right environment for optimal growth and metabolic activity of the organism.
A fermentor usually refers to the containment system for the cultivation of prokaryotic cells, while a bioreactor grows the eukaryotic cells (mammalian, insect cells, etc).

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Types of Bioreactors / Fermenters Types of Bioreactors / Fermenters Presentation Transcript

  • Types of Bioreactor / Fermenter www.technologyinscience.blogspot.com Powerpoint Templates Page 1
  • Bioreactor / Fermenter A bioreactor is basically a device in which the organisms are cultivated to form the desired products. It is a containment system designed to give right environment for optimal growth and metabolic activity of the organism. Powerpoint Templates www.technologyinscience.blogspot.com Page 2
  • Bioreactor / Fermenter Powerpoint Templates Page 3
  • Types of Bioreactors • • • • • • • • Stirred Tank Bioreactor Airlift Bioreactor Packed Bed Bioreactor Fluidized Bed Bioreactor Photo Bioreactor Membrane Bioreactor Rotary Drum Bioreactor Mist Bioreactor Powerpoint Templates www.technologyinscience.blogspot.com Page 4
  • Stirred Tank Bioreactor Powerpoint Templates www.technologyinscience.blogspot.com Page 5
  • Advantages of Stirred Tank Bioreactor • • • • • • • Continuous operation. Good temperature control. Easily adapts to two phase runs. Good control. Simplicity of construction. Low operating cost. Easy to clean. Powerpoint Templates Page 6
  • Disadvantages of Stirred Tank Bioreactor • • The need for shaft seals and bearings. Size limitation by motor size, shaft length & weight. Powerpoint Templates www.technologyinscience.blogspot.com Page 7
  • Airlift Bioreactor Powerpoint Templates Page 8
  • Advantages of Airlift Fermenter • • • • • Simple design Easier sterilization (no agitator shaft parts) Low Energy requirement vs stirred tank Greater heat-removal vs stirred tank Very low cost Powerpoint Templates www.technologyinscience.blogspot.com Page 9
  • Disadvantages of Airlift Fermenter • Greater air throughput and higher pressures needed. • Inefficient break the foam when foaming occurs. • NO bubbles breaker Powerpoint Templates Page 10
  • Packed Bed Bioreactor Powerpoint Templates Page 11
  • Advantages of Packed Bed Reactor • Higher conversion per unit mass of catalyst than other catalytic reactors • Low operating cost • Continuous operation • No moving parts to wear out • Catalyst stays in the reactor • Reaction mixture/catalyst separation is easy • Effective at high temperatures and pressures Powerpoint Templates Page 12
  • Disadvantages of Packed Bed Reactor • • • • • Undesired heat gradients Poor temperature control Difficult to clean Difficult to replace catalyst Undesirable side reactions Powerpoint Templates Page 13
  • Fluidized Bed Bioreactor Powerpoint Templates Page 14
  • Advantages of Fluidized Bed Reactor • Uniform Particle Mixing: • Uniform Temperature Gradients • Ability to Operate Reactor in Continuous State Powerpoint Templates www.technologyinscience.blogspot.com Page 15
  • Disadvantages of Fluidized Bed Reactor • Increased Reactor Vessel Size • Pumping Requirements and Pressure Drop • Particle Entrainment • Lack of Current Understanding • Erosion of Internal Components • Pressure Loss Scenarios Powerpoint Templates www.technologyinscience.blogspot.com Page 16
  • Photo Bioreactor Powerpoint Templates Page 17
  • Advantages of Photobioreactor • • • • Higher productivity Large surface-to-volume ratio Better control of gas transfer. Reduction in evaporation of growth medium. • More uniform temperature. Powerpoint Templates www.technologyinscience.blogspot.com Page 18
  • Disadvantages of Photobioreactor • Capital cost is very high. • The productivity and production cost in some enclosed photobioreactor systems are not much better than those achievable in open-pond cultures. • The technical difficulty in sterilizing Powerpoint Templates www.technologyinscience.blogspot.com Page 19
  • Membrane Bioreactor Powerpoint Templates Page 20
  • Advantages of membrane bioreactor • The loss of enzyme is reduced. • Enzyme lost by denaturation can be made up by periodic addition of enzyme. • Substrate and enzyme can be easily replaced. Powerpoint Templates www.technologyinscience.blogspot.com Page 21
  • Rotary Drum Bioreactor Powerpoint Templates Page 22
  • Advantages of Rotary Drum Reactor • High oxygen transfer. • Good mixing facilitates better growth and impart less hydrodynamic stress. Powerpoint Templates www.technologyinscience.blogspot.com Page 23
  • Disadvantages of Rotary Drum Reactor • Difficult to scale up. Powerpoint Templates www.technologyinscience.blogspot.com Page 24
  • Mist Bioreactor Powerpoint Templates Page 25
  • Advantages of Mist Bioreactor • High oxygen transfer. • Hydrodynamic stress elimination. • Low production cost. Powerpoint Templates www.technologyinscience.blogspot.com Page 26
  • Disadvantages of Mist Bioreactor • Mesh trays and cylindrical stainless steel meshes are required Powerpoint Templates www.technologyinscience.blogspot.com Page 27
  • Click here to read more on Types of Biore www.technologyinscience.blogspot.com Powerpoint Templates Page 28