BOSS 12 conference report Siti Aishah Hasbullah

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Conference report BOSS12 Siti Aishah Hasbullah

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BOSS 12 conference report Siti Aishah Hasbullah

  1. 1. CONFERENCE REPORT BOSS 12 Siti Aishah Hasbullah 20 th October 2010
  2. 2. Prof. Eric JACOBSEN (HARVARD UNIVERSITY, Cambridge, United States) Prof. David MACMILLAN (PRINCETON UNIVERSITY, Princeton, United States)
  3. 3. Tetrahedron Lecture Prof. David MacMillan Princeton University
  4. 4. Tetrahedron Lecture 1: The Advent and Growth of Organocatalysis and Iminium Catalysis <ul><li>The Roots of Organocatalysis: 19 th Century Reaction Discovery </li></ul>Basic for carbene catalysis
  5. 5. The Early Use of Organic Catalysis in Enantioselective Synthesis: Hajos-Parrish <ul><li>Intramolecular Aldol: Hajos-Parrish, JOC , 1974 ,39,1615 </li></ul><ul><li>Extraordinary result that was well received by the chemical synthesis community </li></ul><ul><li>Betweeen 1960 – 2001, no review articles on the collective use of organocatalyst. </li></ul>
  6. 6. Enantioselective Catalysis using Small Organic Molecules: Epoxidation <ul><li>Employed ketones as enantioselectives catalysts </li></ul><ul><li>Demonstrated that organic catalyst could be employed to solve major chemical problems </li></ul><ul><li>Involved the invention of a single catalyst for a single reaction type </li></ul>
  7. 7. MacMillan: The Advent of Iminium Catalysis and the Field of Organocatalysis New Strategies for Organic Catalysis: The First Highly Enantioselective Organocatalytic Diels - Alder Reaction
  8. 8. MacMillan: The Advent of Iminium Catalysis and the Field of Organocatalysis..Cont….. <ul><li>This manuscript conceptualized the field of organocatalysis for the first time in 3 important ways: </li></ul><ul><li>Outlined the potential benefits of using organic molecules as asymmetric catalysts for industry or academia based on cost, availability and ease to use </li></ul><ul><li>Introduced the concept of generic mode of activation for organic catalysis that could be used over many reaction types </li></ul><ul><li>Introduced for the first time, the terminology organocatalysis, organic catalysis and organocatalytic </li></ul>
  9. 9. Tetrahedron Lecture 2: Enamine Catalysis: Teaching and Old Dog Some Tricks Enamine Catalysis : Early Adoption in Catalysis - Woodward-Wieland-Miescher enamine cyclization for steroid synthesis JACS , 1952, 74 , 4223 Helv. Chim. Acta , 1950, 33 , 2215
  10. 10. Bifunctional Enamine Catalysis: Generic Induction Platform Use of proline or proline-type activation a widely exploited mode of ketone activation
  11. 11. Unconventional Reactivity Profiles Induced by Chiral Primary Amines Catalysis Paolo Melchiorre, Inst. Chem Research of Catalonia
  12. 13. Recent Advances in Stereoselectives Synthesis Ilan Marek Technion-Israel Institute of Technology
  13. 15. Directed Evolution of Enzymes: New Biocatalysts for Organic Synthesis Nicholas J. Turner, University of Manchester Enantioselective Biocatalytic Oxidative Desymmetrization of Substituted Pyrrolidines
  14. 17. Seeking Fundamental Insights and Practical Reaction: Asymmetric Catalysis as a Synthetic and Mechanistic Tool Eric Jacobsen, Harvard University Enantioselective Thiourea-Catalyzed Cationic Polycyclizations
  15. 19. Ruthenium Catalyzed Directing Group-Free C2-Selective Carbenoid Functionalization of Indoles by α -Aryldiazoesters Org. Lett, 2010, 12, 604
  16. 20. Ruthenium Diversity: Alkynes, Carbenes and C-H Bonds Pierre H. Dixneuf, Rennes, Frances
  17. 22. Sequential Synthesis of Furans from Alkynes
  18. 24. National University of Malaysia
  19. 25. Welcome to Kuala Lumpur, Malaysia

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