Dengue Hemorrhagic Fever

1,062 views

Published on

Published in: Health & Medicine
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
1,062
On SlideShare
0
From Embeds
0
Number of Embeds
17
Actions
Shares
0
Downloads
33
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Dengue Hemorrhagic Fever

  1. 1. DENGUE
  2. 2. Key point: Early recognition and timely intervention Airamsherlyn P. Natinga, M.D.
  3. 3. DISCUSSION
  4. 4. Epidemiology  estimated 50 million dengue infections occur annually  approximately 2.5 billion people live in dengue endemic countries
  5. 5. Epidemiology  From 1993 to 2007, a total of 307,850 cases of dengue with 3,406 deaths were reported in the Philippines.  Most of the cases occur in children between 1 to 10 years old with a case fatality rate of 1.7%.
  6. 6. “Dengue is one disease entity with different clinical presentations and often with unpredictable clinical evolution and outcome.” Expert consensus groups
  7. 7. Case Classification Expert group (Geneva, Switzerland, 2008)
  8. 8. Criteria for Dengue ± Warning Signs
  9. 9. Herman’s Rash
  10. 10. Dengue with warning signs Severe dengue
  11. 11. Transmission
  12. 12. Dengue virus (DEN)  small single-stranded RNA virus comprising four distinct serotypes (DEN-1 to -4)  genus Flavivirus, family Flaviviridae  Asian genotypes of DEN-2 and DEN-3 are frequently associated with severe disease accompanying secondary dengue infections Dengue virus (DEN)
  13. 13. Vector: Aedes aegypti
  14. 14.  immature stages are found in water-filled habitats, mostly in artificial containers closely associated with human dwellings and often indoors.
  15. 15. Host  After an incubation period of 4-10 days, infection by any of the four virus serotypes can produce a wide spectrum of illness, although most infections are asymptomatic or subclinical
  16. 16. Individual Risk factors  Age  Ethnicity  Chronic illnesses
  17. 17. Blood meal viremia Immune response Genetic Virus Severe dengue Plasma leakage Transient and reversible imbalance of inflammatory mediators, cytokines and chemokines Endothelial cell dysfunction Derangement of hemocoagulation system Shock Bleeding
  18. 18. Course of dengue illness
  19. 19. Clinical problems
  20. 20. Management
  21. 21. Group A  able to tolerate adequate volumes of oral fluids and pass urine at least once every six hours, and do not have any of the warning signs, particularly when fever subsides.  Sent home
  22. 22. Group B  Referred for in-hospital management
  23. 23. Group C  Emergency treatment and urgent referral
  24. 24. Prevention
  25. 25.  Vector control - controlling larval habitats and combatting adult mosquitos by screening widows and doors and using household insecticide space sprays.
  26. 26.  Provision of reliable potable water.  Sanitation  Solid waste management  Health education  COMMUNITY PARTICIPATION
  27. 27. New Avenues  Tetravalent dengue vaccines are under development.

×