Albumin deficiency is termed as ‘Hypoalbuminemia’. It is a condition of abnormally low level of the protein albumin in the blood of human body. The normal range for albumin is 3.5 to 4.5 mg/dL in one single human. If your albumin level is less than 3.5 mg/dL, it is considered low and deficient.

1. Deficiency of Human Serum Albumin in the body
Human Serum Albumin is the most abundant protein in human blood plasma. It is produced in
the liver of human body and constitutes about half of the Human Serum protein. Human
Serum contains dissolved protein like albumin in it for proper flow of blood in the body. It is
responsible to carry out vital substances in the human body like hormones, fatty acids, and
other essential compounds, buffers pH, and to maintain the osmotic pressure, and other major
functions of human body.
In humans, Human Serum Albumin is the most abundant plasma protein, accounting for 55–
60% of the measured serum protein. It consists of a single polypeptide chain of 585 amino acids
with a molecular weight of 66 500 Da. Albumin synthesis takes place only in the liver of human
body and it is not stored by the liver but is secreted into the portal circulation as soon as it is
manufactured.
In healthy young adults, the rate of synthesis is 194 (sd 37) mg per day, or about 12–25 gm of
albumin per day. The rate of synthesis rate varies with nutritional and disease states. The liver
can increase albumin synthesis to only 2–2.7 times normal because most of the liver’s synthetic
machinery is already devoted to albumin at rest. However, there are some conditions where
the production of the substance is lowered and as of this less synthesis the human body is
affected by many diseases.
Albumin deficiency is termed as ‘hypoalbuminemia’. It is a condition of abnormally low level of
the protein albumin in the blood of human body. The normal range for albumin is 3.5 to 4.5
mg/dL in one single human. If your albumin level is less than 3.5 mg/dL, it is considered low and
deficient. Many potential causes of low albumin can be at work, including malnutrition, liver
disease, kidney disease or a stress response etc.
Sometimes, Human Serum Albumin levels are estimated low in the human body because
albumin is being lost from the body as of many other reasons. This majorly happens if you
suffer from a kidney disease such as nephrotic syndrome. In this, tiny blood vessels in the
kidneys called as glomeruli are damaged and allow albumin to leak out into the urine resulting
its loss from the body. Albumin can also be lost from the body due to mal absorption
syndromes such as protein losing enteropathy, inflammatory bowel disease or lymphoma, in
which protein is lost in the stool.
However, in the bloodstream, the Human Serum Albumin transports bilirubin, fatty acids,
metals, ions, hormones and drugs and if it’s content is low, it can affect how the medications
work on the human body. Low albumin levels can also cause edema, or swelling of the tissues
of the human body. Other symptoms include muscle weakness, fatigue, cramps and poor
appetite. In hospitalized patients, a low serum albumin level is associated with increased risk of
morbidity and mortality.

2. Treatment of Hypoalbuminemia or the deficiency of Human Serum Albumin can be treated by
estimating the actual cause of the albumin deficiency and thus by providing proper medications
made from the substitutes along with the adequate dietary intake of protein and calories to the
patients. Human albumin is often used to replace lost fluid and help restore blood volume in
trauma, burns and surgery patients. There are many medications developed recently to replace
the deficiency of all such blood components in the human body, by getting the substances from
healthy humans and preserving them in clinical conditions for future use of it for such lacking
patients. All such substances prove to be life saving for the ailing and deficient persons.
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