Stimulus-triggered fate conversion of
somatic cells into pluripotency
Japanese research team discovered an unexpected
phenomenon of somatic cell reprogramming into pluripotent cells
Introduction
• Stem cells : ability to develop to any kind of cells
• Can be found in body or induced in laboratory
Why stem cells ?
• Cell-based Therapy .. Replace failed systems
• Research tool .. Study development
• resource for testin...
Sources of stem cells
• Naturally :
When cells mature from embryo , some still immature
Bone marrow , blood , adipose tiss...
What is new in this research ?
• Researcher develop a way to generate SC* from adult cells ( acid bath )
• Easy
• Fast
• N...
Designing the experiment
• Cell model : hematopoietic spleen (CD 45+)
• Animal model : mouse
• Conditions : acidic
• pluri...
No study so far has proven that such pluripotent cells can arise from
differentiated somatic cells
Results and discussion
Conclusion
This study show that when adult cells put in sub-lethal conditions it would not die ,
Instead it would converte...
References
Haruko, Obokata, Wakayama Teruhiko, Kojima Koji, Vacanti Martin P, Niwa Hitoshi,
Yamato Masayuki, and Vacanti C...
Done by : Belal Abu Haneya
Hashemite University – Jordan
Supervisor : Dr. Abd Allatif Al Ghzawi
19 - 3 - 2014
Stimulus triggered fate conversion into pluripotency
Stimulus triggered fate conversion into pluripotency
Stimulus triggered fate conversion into pluripotency
Stimulus triggered fate conversion into pluripotency
Stimulus triggered fate conversion into pluripotency
Stimulus triggered fate conversion into pluripotency
Stimulus triggered fate conversion into pluripotency
Stimulus triggered fate conversion into pluripotency
Upcoming SlideShare
Loading in...5
×

Stimulus triggered fate conversion into pluripotency

142

Published on

Stimulus triggered fate conversion into pluripotency

Published in: Education
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total Views
142
On Slideshare
0
From Embeds
0
Number of Embeds
1
Actions
Shares
0
Downloads
3
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide
  • – immune , RBCs* , burned skin , hair loss..The development of embryology and body organs-
  • Transcript of "Stimulus triggered fate conversion into pluripotency"

    1. 1. Stimulus-triggered fate conversion of somatic cells into pluripotency
    2. 2. Japanese research team discovered an unexpected phenomenon of somatic cell reprogramming into pluripotent cells
    3. 3. Introduction • Stem cells : ability to develop to any kind of cells • Can be found in body or induced in laboratory
    4. 4. Why stem cells ? • Cell-based Therapy .. Replace failed systems • Research tool .. Study development • resource for testing new medical treatments
    5. 5. Sources of stem cells • Naturally : When cells mature from embryo , some still immature Bone marrow , blood , adipose tissue • Induced : • Transplantation of nuclei • Modification of somatic cells • Harsh conditions . . Acid bath
    6. 6. What is new in this research ? • Researcher develop a way to generate SC* from adult cells ( acid bath ) • Easy • Fast • No risk
    7. 7. Designing the experiment • Cell model : hematopoietic spleen (CD 45+) • Animal model : mouse • Conditions : acidic • pluripotency markers : Oct 4 ( Nanog, Sax2, Ecat1, Esg1, Dax1 )
    8. 8. No study so far has proven that such pluripotent cells can arise from differentiated somatic cells
    9. 9. Results and discussion
    10. 10. Conclusion This study show that when adult cells put in sub-lethal conditions it would not die , Instead it would converted to the un differentiated situation in which it Would develop to any kind of cells
    11. 11. References Haruko, Obokata, Wakayama Teruhiko, Kojima Koji, Vacanti Martin P, Niwa Hitoshi, Yamato Masayuki, and Vacanti Charles A. "Stimulus-triggered Fate Conversion of Somatic Cells into Pluripotency." Nature.com. Nature Publishing Group, 29 Jan. 2014. Web. 18 Mar. 2014.
    12. 12. Done by : Belal Abu Haneya Hashemite University – Jordan Supervisor : Dr. Abd Allatif Al Ghzawi 19 - 3 - 2014
    1. A particular slide catching your eye?

      Clipping is a handy way to collect important slides you want to go back to later.

    ×