Pancreas

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  • Pancreatic enzymes are only activated once they reach the small intestine
  • Pancreas

    1. 1. PANCREAS
    2. 2. ANATOMY DELICATE LOOSE C.T CAPSULE SOFT LOBULATED HEAD NECK & TAIL PANCREATIC DUCT HEPATO PANCREATIC AMPULLA
    3. 3. PANCREASPARENCHYMA ENDOCRINE EXOCRINESTROMA LOOSE C.T. WITH NUMEROUS B.V. MAST CELLS
    4. 4. EXOCRINE PANCREAS PANCREATIC ENZYMES SEROUS GLAND BRANCHED ACINAR SPHERICAL CLUSTER OF PYRAMIDAL CELLS CENTROACINAR CELLS  INTRAACINAR PART OF INTERCALATED DUCT
    5. 5. SEROUS MUCOUS PYRAMIDAL  COLUMNAR PURPLISH RED WITH BASAL  LIGHTLY EOSINOPHILIC BASOPHILIA ROUND BASAL NUCLEUS  FLATTENED PERIPHERAL NUCLEUS CELL OUTLINES NOT CLEAR  CLEAR LUMEN INDISTINCT ZYMOGEN GRANULES  DISTINCT MYOEPITHELIAL CELLS are  MUCINOGEN VESICLES PROMINENT  NOT PROMINENT
    6. 6. SEROUS MUCOUS
    7. 7. SEROUS MUCOUS Apical microvilli  Apical plasma Laterally intercellur membrane smooth canaliculi, junctional  Intercellular canaliculi complexes & rare infoldings  Dense large closely Golgi complex, Rer packed & ill defined Small discrete  > AGAGS granules secretion < AGAGS
    8. 8. SEROUS MUCOUS
    9. 9. DUCT SYSTEM INTERCALATED SIMPLE CUBOIDA; INTRALOBULAR NO STRIATED DUCT INTERLOBULAR LOW COLUMNAR ENTERO ENDOCRINE GOBLET MAIN PANCREATIC DUCT
    10. 10. CONTROL OF EXOCRINE SECRETION HORMONAL  SECRETIN,CCK NEURONAL SYMPATHETIC REGULATION OF PANCREATIC BLOOD FLOW PARASYMPATHETIC --- ACINAR & CENTROACINAR CELLS HCO3 & H2O  DUCTAL & CENTROACINAR CELLS  VAGAL CHOLINERGIC HORMONAL SECRETIN ENZYMES ACINAR CELLS  VAGAL CHOLINERGIC HORMONAL CCK
    11. 11. ENDOCRINE PANCREAS ISLETS OF LANGERHANS CLUSTERS OF PALE STAINING POLYHEDRAL CELLS > TAIL FENESTRATED CAPILLARIES AUTONOMIC INNERVATION ALPHA BETA & DELTA ( MALLORY AZAN) BETA 70% CENTRE INSULIN ALPHA 10-15% PERIPHERY GLUCAGON,. GIP, CCK, ACTH DELTA 10-15% PERIPHERY SOMATOSTATIN GASTRIN CONTROL OF ENDOCRINE PANCREAS PARASYMPATHETIC INCREASES SECRETION OF INSULIN & GLUCAGON SYMPATHETIC INCREASES GLUCAGON BUT INHIBITS INSULIN
    12. 12. GALL BLADDER
    13. 13. HISTOLOGY MUCOSAL FOLDS (EMPTY) COLUMNAR EPITHELIUM WITH MICROVILLI APICAL JUNCTIONAL COMPLEX & MITOCHONDRIA Na K ATPase LAMINA PROPRIA VASCULAR FENESTRATEDCAPILLARIES & CELLULAR (PLASMA CELLS & LYMPHOCYTES) MUSCULARIS EXTERNA RANDOMLY ORIENTED SMOOTH MUSCLES WITH BUNDLES OF COLLAGEN & ELASTIC FIBER SEROSA / ADVENTITIA  THICK DENSE C.T. BLOOD & LYMPH VESSELS & NERVES ABSORPTION OF H2O & ELECTROLYTE
    14. 14. BILIARY TREE BILE CANALI CULI CANALS OF HERRING INTER LOBULAR BILE DUCTS RIGHT & LEFT HEPATIC DUCTS CYSTIC DUCT BILE DUCT
    15. 15. HISTOLOGY GROOVES B/W ADJACENT HEPATOCYTES JUNCTIONAL COMPLEX SIMPLE CUBOIDAL EPITHELIUM WITH BASAL LAMINA MICROVILLI CUBOIDAL TO COLUMNAR DENSE CONNECTIVE INVESTMENT WITH SMOOTH MUSCLE

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