823998 structure-of-ampiphatic-lipids-and-the-different-complexes
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823998 structure-of-ampiphatic-lipids-and-the-different-complexes

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823998 structure-of-ampiphatic-lipids-and-the-different-complexes 823998 structure-of-ampiphatic-lipids-and-the-different-complexes Presentation Transcript

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    • lipids are insoluble (hydrophobic) in water
    • due to the predominant presence of hydrocarbon groups
    • however, some possess polar or hydrophilic groups which tend to be soluble in water
    • molecules which contain both hydrophobic and hydrophilic groups
    • (Greek – amphi – (both), pathos – passion)
    amphipathic
    • Examples:
    •  
    • Fatty acids
    • Phospholipids
    • Sphingolipids
    • Bile salts
    • Cholesterol (to some extent)
    • Fatty Acids – contain a hydrocarbon chain which is hydrophobic and a carboxyl (COO¯) group which is hydrophilic
    • Phospholipids – have a hydrophilic head
    • ( phosphate group attached to choline, ethanolamine, inositol etc.) and a long hydrophobic tail
    • when the amphipathic lipids are mixed in water
    • (aqueous phase)
    • the polar groups (heads) orient themselves towards aqueous phase while the non polar (tails) orient towards the opposite directions
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    • leads to the formation of micelles
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    • micelle formation, facilitated by bile salts is very important for lipid digestion & absorption
    • represented as a polar or hydrophilic head with a non-polar or hydrophobic tail
    • in case of biological membranes, a bilayer of lipids is formed orienting the polar heads to the outer aqueous phase on either side and the nonpolar tails into the interior
    • the formation of a lipid bilayer is the basis of membrane structure
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    • are produced when amphipathic lipids in aqueous medium are subjected to sonifications
    • they have intermittent aqueous phases in the lipid bilayer
    • liposomes in combination with tissue specific antigens are used as carriers of drugs to target tissues
    • are produced when non polar lipids (e.g. triacylglycerols) are mixed with water
    • the particles are larger in size and stabilized by emulsifying agents (usually amphipathic lipids, - bile salts & phospholipids )
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