Defects in ion channels caused by gene mutations may lead to many diseases, because these disorders affect the movement of ions across the plasma membrane of excitable cells, thus reduce the ability of these cells to develop or transmit impulses.
Victims of CF produce a thickened, sticky mucus( 粘液 ) that is very hard to propel( 推 ) out of the airways( 呼吸道 ). The patients often suffer from chronic( 慢性的 ) lung infections and inflammation, which progressively destroy the lung’s function.
The protein was purified and incorporated into artificial lipid bilayers, it acts as a cAMP-regulated chloride (Cl ˉ ) channel rather than a transporter and also functions in conductance of bicarbonate ions(HCO 3 ˉ ).
It has 12 transmembrane spanning domains, two nucleotide binding domains, and a regulatory domain in the center.
2 ． p.aeruginosa （绿脓杆菌） belongs to the pseudomonas( 假单胞菌属 ). It can bind to the extracellular end of the CFTR protein, which leads to the ingestion and destruction of the bacterium by the epithelial cells. Patients who lack the CFTR can’t clear the bacterium out.
It is also speculated( 推测 ) that the decreased HCO 3 ˉsecretion could lower the pH of the fluid in the airway and provide a more hospitable environment for the bacterium.
To solve the problem of the intracellular decrease of the normal DNA, we can first wipe off the virose gene of AD virus and then link it to the plasmids by covalent bond （共价键） .Thus we produce a new kind of carrier.
To improve the targeted transfer （定向转运）， we can combine certain antibodies or peculiar components to the carrier.