Application of bio implant & biomedical devices-recent advancement and bio-medical science

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Application of bio implant & biomedical devices-recent advancement and bio-medical science

  1. 1. Application  Adverse effects. Recent Advancement Current Priority Research  Conclusion.
  2. 2. Application Of Bio-materials/ medical devices. Adverse effects of Biomaterials/Bio-devices. Recent Advancement of Bio-materials/ Bio- medical Science. Current Priority Research on Biomaterial/ bio-medical science.
  3. 3. Prepared By- Dr. Md Nazrul Islam. MBBS, M.sc.(BME). Supervised By-Associate Prof. ZiaulHaq -MBBS, MS (Orthopedic). 2
  4. 4. Application Of Bio-implant & Biomedical Devices- Biodegradable cranial implant made of PLA-β-TCP produced using SLM.1. Implants for Eye, ENT, Brain2. Implants for Heart, Liver and Kidney.3. Implants for Orthopedic and Dental.
  5. 5. Application OfBio-implant & Biomedical Devices-Implants forEye, ENT, Brain- Lens(ocular) Prosthesis Retinal Prosthesis The Bio-eye (HA) ARTIFICIAL-CORNEA Hydroxyapatite Ocular implant
  6. 6. Application OfBio-implant & BiomedicalImplantsDevices- forEye, ENT, Brain- implanted device Cochlear Implant: to treat balance disorder Most Commonly Used Ear Implant.
  7. 7. Application OfBio-implant & BiomedicalImplantsDevices- forHeart, Liverand Kidney. Implant for Heart:. Stent for Heart:. Implant for Kidney: First Implantable artificial kidney / Technology . Metallic Heart Valve:. Collagen Heart Valve:.
  8. 8. Application OfBio-implant & Biomedical ImplantsDevices- forDental andOrthopedic-BiomaterialFor Hard Tissue- β-tricalcium synthetic•Bone Repair Osteoset—calcium bone product. sulfate pellets.• Joint Implants• Joint Replacements Resorbable Tricalcium Phosphate (β-TCP) Implants for bone void Collagen Bone Graft
  9. 9. Application OfBio-implant & BiomedicalDevices-DentalBiomedical Implants: Metallic Glass- Glass Orthopedic Bone New Bioabsorbable Graft Option for Bone Implants Material For New Bone Growth, Timeline of the recent past, near future, and far future for the use of synthetic dental biomaterials versus truly biological materials An artificial dental crown
  10. 10. Application OfBio-implant & BiomedicalDevices-OrthopedicBiomedical Implants:BiomaterialFor Hard Tissue- Limbs • Bone Repair • Joint Implants • Joint Replacements Orthopedic Implant Finger Plate
  11. 11. Application OfBio-implant & BiomedicalDevices-OrthopedicBiomedical Implants: Biomaterial For Hard Tissue- Lower Limbs KNEE- prosthesis. HIP- prosthesis. ANKLE- prosthesis.
  12. 12. Application OfBio-implant & BiomedicalDevices-OrthopedicBiomedical Implants: Biomaterial- For Hard Tissue- Lower Limbs: Application 5 Composite–(Metal ,Polymer And Ceramic) Hip prostheses. Composite–(Metal ,Polymer And Ceramic) Knee prostheses.
  13. 13. Application OfBio-implant & BiomedicalDevices-OrthopedicBiomedical Implants:Biomaterial-For Hard Tissue- Limbs Patellar Augmentation implant. Ankle- Synthetic Biomaterial Replacement-Prosthesis for Tendon Replacement
  14. 14. Application OfBio-implant & BiomedicalDevices-OrthopedicBiomedical Implants:BiomaterialFor Hard Tissue- Limbs: Application
  15. 15. Application OfBio-implant & BiomedicalDevices-OrthopedicBiomedical Implants: Biomaterial: For Hard Tissue- Spine
  16. 16. Application OfBio-implant & BiomedicalDevices-OrthopedicBiomedical Implants:Biomaterial-For Hard Tissue- Spine: Application Baguera L - Lumbar Disc Prosthesis. MRI compatible
  17. 17. Application OfBio-implant & BiomedicalDevices-OrthopedicBiomedical Implants:Biomaterial- Biodegradable:For Hard Tissue- Limbs & Spine 5
  18. 18. Application OfBio-implant & BiomedicalDevices-Biomaterial-For Soft Tissue- Tissue Engineering Of Skin - Withy Polymer Scaffold Polyform® Synthetic Mesh Bio-Engineering Hydro-gel for Tissue Repair
  19. 19. Application OfBio-implant & BiomedicalDevices-Biomaterial-For Soft Tissue- Tissue Engineering Of Skin – for Burn Patients
  20. 20. Application OfBio-implant & BiomedicalDevices- Cancer detection from an implantable device, Insulin Pumps - Diabetes 1. Artificial Device / Organs for Eye, ENT, Brain 2. Artificial Device / Organs for Heart, Lungs, Liver and Kidney. 3. Artificial Device/Organs for Dental, Maxillofacial and Orthopedic.
  21. 21. Classification:  Class I: General controls.  Class II: General controls with special controls (infusion pumps, and surgical drapes…).  Class III: General controls and premarket approval (implantable pacemaker, pulse generators, automated external defibrillators).
  22. 22. Application OfBio-implant & Biomedical ArtificialDevices-Device/ OrgansforEye, ENT, Brain Scientists Set Sights on an Implantable Prosthetic for the Blind . Implantable Miniature Telescope for Macular Degeneration Implantable Smart Chip implantable- device- seizure Fights Chronic Pain -
  23. 23. Application OfArtificial Device/Bio-implant & BiomedicalOrgansDevices-ForHeart,Lungs,Liver,Kidney and Stomach. Artificial Lung Without Need for Extra Oxygen Artificial Heart iv ad Device blocking stomach n signals shows promise in o
  24. 24. Application OfBio-implant & BiomedicalDevices- Application: Pace-maker in-situ. First_pacemaker_ Siemens-Elema_19581 Blood-power-hydroelectric-turbine... devices that use Small turbines designed to fit inside a human artery.
  25. 25. Application OfBio-implant & BiomedicalArtificialDevices- Device/OrgansFor Heart, Lungs, Liverand Kidney. Liver device helps man survive until transplant – FGate 6
  26. 26. Application OfBio-implant & BiomedicalArtificialDevices- Device/OrgansFor Heart, Lungs, Liverand Kidney. 5 Artificial mechanical kidney
  27. 27. Application OfArtificialBio-implant & Biomedical Device/Devices-Organsfor Dental andOrthopedicImplantation. Surgically implanted titanium And stainless steel plates Flexible (nylon) dental prostheses. Composite– (Metal and Orthopedic /Dental Ceramic) dental prostheses. Implants Pulse Generators (CRM
  28. 28. Application OfArtificialBio-implant & Biomedical Device/Devices-Organsfor Dental andOrthopedicImplantation. Wireless Implantable Chip Delivers Osteoporosis Drug- When It Is Needed. Remote Control- Microchips ... 9
  29. 29. AdverseEffects Of Biomaterial/Bio-device: Hemolysis,Thrombosis & Coagulation. (Exaggerated)  Inflammation Acute Inflammation (Exaggerated) Chronic Inflammation (Specific for foreign body)  Immunogenicity and toxicity  Infection  Corrosion/ Wear/ Tear  Loosening  Fracture of implant and bone  Rejection of Implant  Tumorogenesis /Carcinogenesis.
  30. 30. Recent Advancement Of Biomaterial/Biomedical Science.Mesh_Titanium_orthopedic implant.
  31. 31. Recent AdvancementOf BiomaterialScience.Biodegradable Biomaterial.
  32. 32. Recent AdvancementOf BiomaterialScience. Biomaterials that form bonds with the living tissues and perform specific biological response at the interface - • Capable of direct chemical bonding with the host tissue. • Stimulatory effects on bone-building cells. IdealBioglass SiO2, cement filler and o as bone coating due Na2its biological activity– oCaO and to O, Cannot Calcium Phosphate. o be used for load bearing Bone ingrowth around applications- synthetic hydroxyapatite
  33. 33. Recent AdvancementOf BiomaterialBiologicScience.Biomaterials. Are Biological components- either from- Natural (Plant), or xeno, allo or auto biological components- Whole /part of Cell- adult /stem, Cell-secreted extracellular matrix or fluid, Living Tissue Components (e.g. Collagen, liver or pancreatic tissue) or Lab grown biological cell, fluid/ tissue or organ to augment, regenerate, replace or implantation in the living biological system. Implantation of cell / tissue / fluid for regeneration. Research of interest  Restorable Collagen- Based Medical Implant/ tissue. -  Tissue Engineering for Tissue and Organ Regeneration.
  34. 34. Recent Advancement Of Biomaterial Science. Tissue Engineering For Tissue and Organ Regeneration. Stem Cell Researchers – An artificial human trachea implanted in A Step Closer to Sweden: A cancer patient has received the first synthetic windpipe transplant. Growing New Organs- 5The synthetic scaffold of an ear sits bathed in cartilage-producing cells, part of an effort to grow new ears forwounded soldiers.
  35. 35. Recent Advancement Of Biomaterial Science. RestorableCollagen- BasedMedicalImplant. Collagen is an important ECM molecule and is the major structural component in the body. 5 It is biocompatible and degrades into harmless products that are metabolized or excreted. a very Pulpal poor antigen , non- toxic. Regeneration -
  36. 36. Antibiotic- coatedRecent Advancement Bio-Of BiomaterialScience. implants/de vice -  New multifunctional ciprofloxacin-releasing SR-PLGA 80/20 screws (A).  Screws that do not contain ciprofloxacin (B).
  37. 37. Recent AdvancementOf BiomaterialAesthetic/Science.CosmeticBiomaterial. Nose implants Popular- cosmetic-dental- treatments- Porous-polyethylene-implant-Reconstruction of the total external ear has two major approaches- alloplastic prosthesis implantation. Cosmetic-dentistry-
  38. 38. Recent AdvancementOf BiomaterialScience.AestheticBiomaterial. Popular- Aesthetic Replacement of Testis- 5
  39. 39. Recent AdvancementOf BiomaterialScience.CosmeticBiomaterial.Biomaterialsin plastic -surgery- Saline-breast implant 5 Autogenous-cartilage-graft Silicone-breast implant in-situ
  40. 40. RecentAdvancementMicro-chipOf BiomaterialScience.ControlledBionic Devices. Bionic bodies have been depicted in science fiction for decades. Now, researchers are making bionics the new frontier of medical science, by creating hi-tech devices to help people walk, see and hear again. 8
  41. 41. RecentAdvancement • Positron emission tomography (PET)Of Biomaterial • Single photon emission computedInnovation-Science. tomography (SPECT) • Magnetic resonance imaging (MRI)MolecularImaging Technique› • Computed tomography (CT) • Optical bioluminescence imaging • Optical fluorescence imaging • Ultrasound. Molecular imaging is a new biomedical research discipline enabling the visualization, characterization, and quantification of biologic processes taking place at the cellular and sub- cellular levels. Human Bone Osteosarcoma Cells (Fluorescent Digital Image technology) It provides a number of unique advantages over more traditional tools such as histology: Non-Invasive  Real-Time  Physiological Conditions  Intact Tissue  Living Subject  Longitudinal and Quantitative  Assessments Complementary to Histology. Bimolecular Image of Chest-
  42. 42. Current Priority ResearchOn Biomedical/ BiomaterialScience. Application:  Genomic and personalized medicine. Nano -technology oriented Medical science and Regenerative Medicine.  3rd And 4th Generation Biomaterial – • Tissue Engineered- Cell and Gene activating Biomaterials. • Adult/Stem Cell derived Advance d cell, tissue/Organ and Medication. Biomate rial-  Innovation: Regener ative  Biodegradable and Bioactive- medicin e, able biomaterial8 /drug delivery system. to  Biocompatible and comfortable bionic interac t with living limbs/ Organs. cells,  Newer technology for and to promote Aesthetic,Cosmetic,Dental,Orthopedic & tissue repair. Maxillofacial Surgery.  Bio-fuel/auto-fueled/ Self controlled Biomedical devices.
  43. 43. Current Priority ResearchOn Biomedical/ Biomaterial Science-Stem CellResearch:Live human lungs grown in lab using stemcells in potential transplant breakthrough - 8
  44. 44. Current Priority ResearchOn Biomedical/ Biomaterial Science-Stem CellResearch:Live human heart grown in lab using stemcells in potential transplant breakthrough- 6
  45. 45. Current Priority ResearchOn Biomedical/ Biomaterial Science-Stem CellResearch:Dr. Anthony Ata-la and his team has grownbladders and blood vessels using Stem Cell. Tissue Engineered Bladder
  46. 46. Current Priority ResearchOn Biomedical/ Biomaterial Science-Stem CellResearch: Spray On Stem Cells for Treating Burns and Open Wounds–Regenerative
  47. 47.  Most current applications of biomaterials /biomedical device involve structural functions, or very simple chemical or electrical functions. Complex chemical functions (e.g., those of liver), and Complex electrical or electrochemical functions (e.g., those of brain and sense organs) – cannot be carried out by biomaterials.Regenerative Medicine  Transplantation of organs and tissuesIn 2012- Assessing Predictions is inevitable when biomaterials are not
  48. 48. Tissue engineering will change the faceof biomaterials. Regenerative medicine will reduce theneed for synthetic materials in the body. In the near-future, biomaterials will beincorporated with biological factors(such as bone growth) directly into animplant’s surface to improvebiocompatibility and bioactivity. Bionic device- Now researchers aremaking bionics, the new frontier ofmedical science, by creating hi-techdevices to help people walk, see andhear again.
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