Application of  bio implant & biomedical devices-recent advancement and bio-medical science
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Application of bio implant & biomedical devices-recent advancement and bio-medical science

Application of bio implant & biomedical devices-recent advancement and bio-medical science

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Application of bio implant & biomedical devices-recent advancement and bio-medical science Presentation Transcript

  • 1. Application  Adverse effects. Recent Advancement Current Priority Research  Conclusion.
  • 2. Application Of Bio-materials/ medical devices. Adverse effects of Biomaterials/Bio-devices. Recent Advancement of Bio-materials/ Bio- medical Science. Current Priority Research on Biomaterial/ bio-medical science.
  • 3. Prepared By- Dr. Md Nazrul Islam. MBBS, M.sc.(BME). Supervised By-Associate Prof. ZiaulHaq -MBBS, MS (Orthopedic). 2
  • 4. Application Of Bio-implant & Biomedical Devices- Biodegradable cranial implant made of PLA-β-TCP produced using SLM.1. Implants for Eye, ENT, Brain2. Implants for Heart, Liver and Kidney.3. Implants for Orthopedic and Dental.
  • 5. Application OfBio-implant & Biomedical Devices-Implants forEye, ENT, Brain- Lens(ocular) Prosthesis Retinal Prosthesis The Bio-eye (HA) ARTIFICIAL-CORNEA Hydroxyapatite Ocular implant
  • 6. Application OfBio-implant & BiomedicalImplantsDevices- forEye, ENT, Brain- implanted device Cochlear Implant: to treat balance disorder Most Commonly Used Ear Implant.
  • 7. Application OfBio-implant & BiomedicalImplantsDevices- forHeart, Liverand Kidney. Implant for Heart:. Stent for Heart:. Implant for Kidney: First Implantable artificial kidney / Technology . Metallic Heart Valve:. Collagen Heart Valve:.
  • 8. Application OfBio-implant & Biomedical ImplantsDevices- forDental andOrthopedic-BiomaterialFor Hard Tissue- β-tricalcium synthetic•Bone Repair Osteoset—calcium bone product. sulfate pellets.• Joint Implants• Joint Replacements Resorbable Tricalcium Phosphate (β-TCP) Implants for bone void Collagen Bone Graft
  • 9. Application OfBio-implant & BiomedicalDevices-DentalBiomedical Implants: Metallic Glass- Glass Orthopedic Bone New Bioabsorbable Graft Option for Bone Implants Material For New Bone Growth, Timeline of the recent past, near future, and far future for the use of synthetic dental biomaterials versus truly biological materials An artificial dental crown
  • 10. Application OfBio-implant & BiomedicalDevices-OrthopedicBiomedical Implants:BiomaterialFor Hard Tissue- Limbs • Bone Repair • Joint Implants • Joint Replacements Orthopedic Implant Finger Plate
  • 11. Application OfBio-implant & BiomedicalDevices-OrthopedicBiomedical Implants: Biomaterial For Hard Tissue- Lower Limbs KNEE- prosthesis. HIP- prosthesis. ANKLE- prosthesis.
  • 12. Application OfBio-implant & BiomedicalDevices-OrthopedicBiomedical Implants: Biomaterial- For Hard Tissue- Lower Limbs: Application 5 Composite–(Metal ,Polymer And Ceramic) Hip prostheses. Composite–(Metal ,Polymer And Ceramic) Knee prostheses.
  • 13. Application OfBio-implant & BiomedicalDevices-OrthopedicBiomedical Implants:Biomaterial-For Hard Tissue- Limbs Patellar Augmentation implant. Ankle- Synthetic Biomaterial Replacement-Prosthesis for Tendon Replacement
  • 14. Application OfBio-implant & BiomedicalDevices-OrthopedicBiomedical Implants:BiomaterialFor Hard Tissue- Limbs: Application
  • 15. Application OfBio-implant & BiomedicalDevices-OrthopedicBiomedical Implants: Biomaterial: For Hard Tissue- Spine
  • 16. Application OfBio-implant & BiomedicalDevices-OrthopedicBiomedical Implants:Biomaterial-For Hard Tissue- Spine: Application Baguera L - Lumbar Disc Prosthesis. MRI compatible
  • 17. Application OfBio-implant & BiomedicalDevices-OrthopedicBiomedical Implants:Biomaterial- Biodegradable:For Hard Tissue- Limbs & Spine 5
  • 18. Application OfBio-implant & BiomedicalDevices-Biomaterial-For Soft Tissue- Tissue Engineering Of Skin - Withy Polymer Scaffold Polyform® Synthetic Mesh Bio-Engineering Hydro-gel for Tissue Repair
  • 19. Application OfBio-implant & BiomedicalDevices-Biomaterial-For Soft Tissue- Tissue Engineering Of Skin – for Burn Patients
  • 20. Application OfBio-implant & BiomedicalDevices- Cancer detection from an implantable device, Insulin Pumps - Diabetes 1. Artificial Device / Organs for Eye, ENT, Brain 2. Artificial Device / Organs for Heart, Lungs, Liver and Kidney. 3. Artificial Device/Organs for Dental, Maxillofacial and Orthopedic.
  • 21. Classification:  Class I: General controls.  Class II: General controls with special controls (infusion pumps, and surgical drapes…).  Class III: General controls and premarket approval (implantable pacemaker, pulse generators, automated external defibrillators).
  • 22. Application OfBio-implant & Biomedical ArtificialDevices-Device/ OrgansforEye, ENT, Brain Scientists Set Sights on an Implantable Prosthetic for the Blind . Implantable Miniature Telescope for Macular Degeneration Implantable Smart Chip implantable- device- seizure Fights Chronic Pain -
  • 23. Application OfArtificial Device/Bio-implant & BiomedicalOrgansDevices-ForHeart,Lungs,Liver,Kidney and Stomach. Artificial Lung Without Need for Extra Oxygen Artificial Heart iv ad Device blocking stomach n signals shows promise in o
  • 24. Application OfBio-implant & BiomedicalDevices- Application: Pace-maker in-situ. First_pacemaker_ Siemens-Elema_19581 Blood-power-hydroelectric-turbine... devices that use Small turbines designed to fit inside a human artery.
  • 25. Application OfBio-implant & BiomedicalArtificialDevices- Device/OrgansFor Heart, Lungs, Liverand Kidney. Liver device helps man survive until transplant – FGate 6
  • 26. Application OfBio-implant & BiomedicalArtificialDevices- Device/OrgansFor Heart, Lungs, Liverand Kidney. 5 Artificial mechanical kidney
  • 27. Application OfArtificialBio-implant & Biomedical Device/Devices-Organsfor Dental andOrthopedicImplantation. Surgically implanted titanium And stainless steel plates Flexible (nylon) dental prostheses. Composite– (Metal and Orthopedic /Dental Ceramic) dental prostheses. Implants Pulse Generators (CRM
  • 28. Application OfArtificialBio-implant & Biomedical Device/Devices-Organsfor Dental andOrthopedicImplantation. Wireless Implantable Chip Delivers Osteoporosis Drug- When It Is Needed. Remote Control- Microchips ... 9
  • 29. AdverseEffects Of Biomaterial/Bio-device: Hemolysis,Thrombosis & Coagulation. (Exaggerated)  Inflammation Acute Inflammation (Exaggerated) Chronic Inflammation (Specific for foreign body)  Immunogenicity and toxicity  Infection  Corrosion/ Wear/ Tear  Loosening  Fracture of implant and bone  Rejection of Implant  Tumorogenesis /Carcinogenesis.
  • 30. Recent Advancement Of Biomaterial/Biomedical Science.Mesh_Titanium_orthopedic implant.
  • 31. Recent AdvancementOf BiomaterialScience.Biodegradable Biomaterial.
  • 32. Recent AdvancementOf BiomaterialScience. Biomaterials that form bonds with the living tissues and perform specific biological response at the interface - • Capable of direct chemical bonding with the host tissue. • Stimulatory effects on bone-building cells. IdealBioglass SiO2, cement filler and o as bone coating due Na2its biological activity– oCaO and to O, Cannot Calcium Phosphate. o be used for load bearing Bone ingrowth around applications- synthetic hydroxyapatite
  • 33. Recent AdvancementOf BiomaterialBiologicScience.Biomaterials. Are Biological components- either from- Natural (Plant), or xeno, allo or auto biological components- Whole /part of Cell- adult /stem, Cell-secreted extracellular matrix or fluid, Living Tissue Components (e.g. Collagen, liver or pancreatic tissue) or Lab grown biological cell, fluid/ tissue or organ to augment, regenerate, replace or implantation in the living biological system. Implantation of cell / tissue / fluid for regeneration. Research of interest  Restorable Collagen- Based Medical Implant/ tissue. -  Tissue Engineering for Tissue and Organ Regeneration.
  • 34. Recent Advancement Of Biomaterial Science. Tissue Engineering For Tissue and Organ Regeneration. Stem Cell Researchers – An artificial human trachea implanted in A Step Closer to Sweden: A cancer patient has received the first synthetic windpipe transplant. Growing New Organs- 5The synthetic scaffold of an ear sits bathed in cartilage-producing cells, part of an effort to grow new ears forwounded soldiers.
  • 35. Recent Advancement Of Biomaterial Science. RestorableCollagen- BasedMedicalImplant. Collagen is an important ECM molecule and is the major structural component in the body. 5 It is biocompatible and degrades into harmless products that are metabolized or excreted. a very Pulpal poor antigen , non- toxic. Regeneration -
  • 36. Antibiotic- coatedRecent Advancement Bio-Of BiomaterialScience. implants/de vice -  New multifunctional ciprofloxacin-releasing SR-PLGA 80/20 screws (A).  Screws that do not contain ciprofloxacin (B).
  • 37. Recent AdvancementOf BiomaterialAesthetic/Science.CosmeticBiomaterial. Nose implants Popular- cosmetic-dental- treatments- Porous-polyethylene-implant-Reconstruction of the total external ear has two major approaches- alloplastic prosthesis implantation. Cosmetic-dentistry-
  • 38. Recent AdvancementOf BiomaterialScience.AestheticBiomaterial. Popular- Aesthetic Replacement of Testis- 5
  • 39. Recent AdvancementOf BiomaterialScience.CosmeticBiomaterial.Biomaterialsin plastic -surgery- Saline-breast implant 5 Autogenous-cartilage-graft Silicone-breast implant in-situ
  • 40. RecentAdvancementMicro-chipOf BiomaterialScience.ControlledBionic Devices. Bionic bodies have been depicted in science fiction for decades. Now, researchers are making bionics the new frontier of medical science, by creating hi-tech devices to help people walk, see and hear again. 8
  • 41. RecentAdvancement • Positron emission tomography (PET)Of Biomaterial • Single photon emission computedInnovation-Science. tomography (SPECT) • Magnetic resonance imaging (MRI)MolecularImaging Technique› • Computed tomography (CT) • Optical bioluminescence imaging • Optical fluorescence imaging • Ultrasound. Molecular imaging is a new biomedical research discipline enabling the visualization, characterization, and quantification of biologic processes taking place at the cellular and sub- cellular levels. Human Bone Osteosarcoma Cells (Fluorescent Digital Image technology) It provides a number of unique advantages over more traditional tools such as histology: Non-Invasive  Real-Time  Physiological Conditions  Intact Tissue  Living Subject  Longitudinal and Quantitative  Assessments Complementary to Histology. Bimolecular Image of Chest-
  • 42. Current Priority ResearchOn Biomedical/ BiomaterialScience. Application:  Genomic and personalized medicine. Nano -technology oriented Medical science and Regenerative Medicine.  3rd And 4th Generation Biomaterial – • Tissue Engineered- Cell and Gene activating Biomaterials. • Adult/Stem Cell derived Advance d cell, tissue/Organ and Medication. Biomate rial-  Innovation: Regener ative  Biodegradable and Bioactive- medicin e, able biomaterial8 /drug delivery system. to  Biocompatible and comfortable bionic interac t with living limbs/ Organs. cells,  Newer technology for and to promote Aesthetic,Cosmetic,Dental,Orthopedic & tissue repair. Maxillofacial Surgery.  Bio-fuel/auto-fueled/ Self controlled Biomedical devices.
  • 43. Current Priority ResearchOn Biomedical/ Biomaterial Science-Stem CellResearch:Live human lungs grown in lab using stemcells in potential transplant breakthrough - 8
  • 44. Current Priority ResearchOn Biomedical/ Biomaterial Science-Stem CellResearch:Live human heart grown in lab using stemcells in potential transplant breakthrough- 6
  • 45. Current Priority ResearchOn Biomedical/ Biomaterial Science-Stem CellResearch:Dr. Anthony Ata-la and his team has grownbladders and blood vessels using Stem Cell. Tissue Engineered Bladder
  • 46. Current Priority ResearchOn Biomedical/ Biomaterial Science-Stem CellResearch: Spray On Stem Cells for Treating Burns and Open Wounds–Regenerative
  • 47.  Most current applications of biomaterials /biomedical device involve structural functions, or very simple chemical or electrical functions. Complex chemical functions (e.g., those of liver), and Complex electrical or electrochemical functions (e.g., those of brain and sense organs) – cannot be carried out by biomaterials.Regenerative Medicine  Transplantation of organs and tissuesIn 2012- Assessing Predictions is inevitable when biomaterials are not
  • 48. Tissue engineering will change the faceof biomaterials. Regenerative medicine will reduce theneed for synthetic materials in the body. In the near-future, biomaterials will beincorporated with biological factors(such as bone growth) directly into animplant’s surface to improvebiocompatibility and bioactivity. Bionic device- Now researchers aremaking bionics, the new frontier ofmedical science, by creating hi-techdevices to help people walk, see andhear again.
  • 49. &
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