Meningitis

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this is a series of lectures on microbiology useful for undergraduate and postgraduate, medical and paramedical students

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Meningitis

  1. 1. Meningitis Dr. Ashish V. Jawarkar
  2. 2. The Central nervous system Consists of: Brain Spinal cord ventricles CSF Peripheral nerves Dr. Ashish V. Jawarkar
  3. 3. Meningitis Inflammation of the membranes surrounding the brain and spinal cord Most common organisms    Haemophilus influenzae Streptococcus pneumoniae Neisseria meningitidis Dr. Ashish V. Jawarkar
  4. 4. H. Influenzae Morphology   Gram negative Cocco-bacillary Dr. Ashish V. Jawarkar
  5. 5. Growth requirements on culture Factor X – haemin Factor V – NAD – nicotineamide adenine dinucleotide Dr. Ashish V. Jawarkar
  6. 6. Sattelitism Dr. Ashish V. Jawarkar
  7. 7. Types Capsulated (type B) – cause meningitis, conjunctivitis, bacteriemia, pneumonia, arthritis, endocarditis  children Non capsulated – infections of respiratory tract  adults Dr. Ashish V. Jawarkar
  8. 8. Meningitis Dr. Ashish V. Jawarkar
  9. 9. Lab diagnosis Sample – CSF Lumbar puncture Gram stain – gram negative cocco bacilli Latex particle agglutination test Culture – blood agar or chocolate agar with added factor X and V Dr. Ashish V. Jawarkar
  10. 10. Treatment Cefotaxime Augmentin Cotrimoxazole Dr. Ashish V. Jawarkar
  11. 11. Neisseria Two types   N. meningitidis (meningococci) - meningitis N. gonorrhoe – Uro genital infections Dr. Ashish V. Jawarkar
  12. 12. Meningococci Morphology   Gram negative diplococci Dr. Ashish V. Jawarkar
  13. 13. Pathogenicity Cerebrospinal meningitis   Acute fever with chills Rash Meningococcal septicemia   Shock Multisystem failure Dr. Ashish V. Jawarkar
  14. 14. Dr. Ashish V. Jawarkar
  15. 15. Lab diagnosis Sample – CSF Gram stain Latex agglutination test Culture Nasal swab for detection of carriers Dr. Ashish V. Jawarkar
  16. 16. Treatment IV penicillin G Third generation cephalosporin Dr. Ashish V. Jawarkar
  17. 17. Dr. Ashish V. Jawarkar

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