Meningitis
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Meningitis

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this is a series of lectures on microbiology useful for undergraduate and postgraduate, medical and paramedical students

this is a series of lectures on microbiology useful for undergraduate and postgraduate, medical and paramedical students

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Meningitis Meningitis Presentation Transcript

  • Meningitis Dr. Ashish V. Jawarkar
  • The Central nervous system Consists of: Brain Spinal cord ventricles CSF Peripheral nerves Dr. Ashish V. Jawarkar
  • Meningitis Inflammation of the membranes surrounding the brain and spinal cord Most common organisms    Haemophilus influenzae Streptococcus pneumoniae Neisseria meningitidis Dr. Ashish V. Jawarkar
  • H. Influenzae Morphology   Gram negative Cocco-bacillary Dr. Ashish V. Jawarkar
  • Growth requirements on culture Factor X – haemin Factor V – NAD – nicotineamide adenine dinucleotide Dr. Ashish V. Jawarkar
  • Sattelitism Dr. Ashish V. Jawarkar
  • Types Capsulated (type B) – cause meningitis, conjunctivitis, bacteriemia, pneumonia, arthritis, endocarditis  children Non capsulated – infections of respiratory tract  adults Dr. Ashish V. Jawarkar
  • Meningitis Dr. Ashish V. Jawarkar
  • Lab diagnosis Sample – CSF Lumbar puncture Gram stain – gram negative cocco bacilli Latex particle agglutination test Culture – blood agar or chocolate agar with added factor X and V Dr. Ashish V. Jawarkar
  • Treatment Cefotaxime Augmentin Cotrimoxazole Dr. Ashish V. Jawarkar
  • Neisseria Two types   N. meningitidis (meningococci) - meningitis N. gonorrhoe – Uro genital infections Dr. Ashish V. Jawarkar
  • Meningococci Morphology   Gram negative diplococci Dr. Ashish V. Jawarkar
  • Pathogenicity Cerebrospinal meningitis   Acute fever with chills Rash Meningococcal septicemia   Shock Multisystem failure Dr. Ashish V. Jawarkar
  • Dr. Ashish V. Jawarkar
  • Lab diagnosis Sample – CSF Gram stain Latex agglutination test Culture Nasal swab for detection of carriers Dr. Ashish V. Jawarkar
  • Treatment IV penicillin G Third generation cephalosporin Dr. Ashish V. Jawarkar
  • Dr. Ashish V. Jawarkar