• Like


Flash Player 9 (or above) is needed to view presentations.
We have detected that you do not have it on your computer. To install it, go here.

What is Thalassemia?

Uploaded on


  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Be the first to comment
    Be the first to like this
No Downloads


Total Views
On Slideshare
From Embeds
Number of Embeds



Embeds 0

No embeds

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

    No notes for slide


  • 1. What is Thalassemia?
  • 2. What is Thalassemia?
    Thalassemia is the name of a group of inherited blood disorders. Hemoglobin, the part of red blood cells that carries the oxygen, is made up of 2 proteins, Alpha and Beta. If the body has an imbalance, the red blood cells cannot carry enough oxygen.
  • 3. Alpha Thalassemia is when you do not have enough protein in your hemoglobin. It is commonly found in people from Africa, the Middle East, India, Southeast Asia, Southern China and sometimes the Mediterranean. There are several types of Alpha Thalassemia, ranging from mild to severe:
    Silent Carrier State: Only a small lack of Alpha protein, so generally there are no health problems.
    Alpha Thalassemia Trait or Mild Alpha Thalassemia: Lacking enough protein to cause mild symptoms sometimes, which are similar to iron deficiency anemia.
    Hemoglobin H disease: Enough Alpha protein lacking to cause severe anemia and significant health problems. Such as bone deformities, enlarged spleen and fatigue. The most severe form of Alpha Thalassemia Major causes stillbirth (death of an unborn fetus during pregnancy). Children born with Thalassemia Major, (Cooley’s Anemia), are normal at birth and develop Thalassemia during the first year of their life.
  • 4. Symptoms
    symptoms include:
    Bone deformities in the face
    Growth Failure
    Yellow Skin
    *Persons with the minor form of Alpha Beta Thalassemia have small red blood cells, but no symptoms.  
  • 5. Treatment
    Patients with thalassemia minor usually do not require any specific treatment.
    Treatment for patients with thalassemia major includes chronic blood transfusion therapy, iron chelation, splenectomy, and allogeneic hematopoietic transplantation.
  • 6. Medication
    Medical therapy for beta thalassemia primarily involves iron chelation. Deferoxamine is the intravenously or subcutaneously administered chelation agent currently approved for use in the United States. Deferasirox (Exjade) is an oral iron chelation drug also approved in the US in 2005. Deferoprone is an oral iron chelator that has been approved in Europe since 1999 and many other countries. It is available under compassionate use guidelines in the United States.
  • 7. Benefits
    Being a carrier of the disease may confer a degree of protection against malaria, as it is quite common among people of Italian or Greek origin, and also in some African and Indian regions. This is probably by making the red blood cells more susceptible to the less lethal species Plasmodium vivax, simultaneously making the host's red blood cell (RBC) environment unsuitable for the merozoites of the more lethal strain Plasmodium falciparum. This is believed to be a selective survival advantage for patients with the various thalassemia traits. In that respect it resembles another genetic disorder, sickle-cell disease.