Loading…

Flash Player 9 (or above) is needed to view presentations.
We have detected that you do not have it on your computer. To install it, go here.

Like this document? Why not share!

Alpha Thalassemia

on

  • 1,244 views

 

Statistics

Views

Total Views
1,244
Views on SlideShare
1,244
Embed Views
0

Actions

Likes
0
Downloads
13
Comments
0

0 Embeds 0

No embeds

Accessibility

Categories

Upload Details

Uploaded via as Adobe PDF

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

    Alpha Thalassemia Alpha Thalassemia Document Transcript

    • Alpha Thalassemia Physicians often People who do not produce enough alpha globin protein chains have alpha thalassemia. It is commonly found in mistake Africa, the Middle East, India, Southeast Asia, southern alpha thalassemia α α China, and occasionally the Mediterranean region. trait for iron Alpha globin is made by four genes, two on each strand of chromosome 16. Individuals who have one or two abnormal deficiency anemia alpha globin genes have alpha thalassemia trait. and incorrectly An individual with one abnormal alpha globin gene is said to prescribe iron α α be a silent carrier of alpha thalassemia. This condition, in which one of the four alpha globin genes is missing or supplements that defective, generally causes no health problems because the have no effect lack of alpha globin protein is so small that there is no 1 anemia. on the anemia. Normal alpha globin It is called "silent carrier" because of how difficult it is to genes found on detect. Silent carrier state is "diagnosed" by deduction chromosome 16 when an apparently normal individual has a child with hemoglobin H disease or alpha thalassemia minor. It can also be diagnosed by special DNA testing. An individual with two abnormal alpha globin genes is said to have alpha thalassemia trait. The two abnormal genes can be on the same chromosome or on each chromosome in the pair. α α α α − − − − Alpha Thalassemia Trait. In this condition, in which two of the four alpha globin genes are missing or If both parents carry alpha thalassemia trait in which the two abnormal defective, the lack of alpha globin protein genes of each parent are on opposite chromosomes, their children will is somewhat greater. Both abnormal alpha inherit alpha thalassemia trait. globin genes may be on the same chromosome (cis position) or one may be on each chromosome in the pair (trans position). Physicians often mistake alpha thalassemia trait for iron deficiency anemia and alpha thalassemia incorrectly prescribe iron trait supplements that have no effect on the anemia. Patients with this condition have smaller red blood cells α α and a mild anemia, although they do not experience − − symptoms. (800) 522-7222 or info@cooleysanemia.org www.cooleysanemia.org
    • The alpha thalassemia traits combine in different ways to produce blood disorders that range from mild to severe in their effect on the human body. α − α α if... α − α − ..then there is a 25% chance with each one parent has alpha and the other parent has pregnancy that their child will be born with thalassemia trait with the silent carrier state with hemoglobin H disease in which three of two abnormal alpha a single abnormal alpha glo- the four alpha globin genes are abnormal. globin genes on the same bin gene on one chromosome chromosome In this condition, the lack of alpha protein is great enough to cause moderate to severe anemia and may cause 25% 25% 25% 25% hemoglobin H serious health problems such as an enlarged spleen, bone disease deformities and fatigue. α α − α α α − α 2 α α − α α − − − normal alpha thal alpha thal hemoglobin trait silent carrier α − α − if... α − α − ..then there is a 25% chance with each both parents carry alpha thalassemia trait with two pregnancy that their child will inherit abnormal alpha globin genes on the same chromosome hydrops fetalis or alpha thalassemia major, in which all four alpha globin genes are abnormal. Most individuals with this condition die before or shortly after birth. In some extremely rare cases, in 25% 50% 25% hydrops fetalis utero blood transfusions have allowed the birth of children (alpha thal major) with hydrops fetalis who then require lifelong blood transfusions and extensive ongoing medical care. α α α − − − α α α − − − normal alpha thal hemoglobin trait (cis Type) (800) 522-7222 or info@cooleysanemia.org www.cooleysanemia.org