Lignans and neolignans

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Lignans and neolignans

  1. 1. Presented to SIR TANVEER KHAN Presented by ZAINAB JAVED MPhil Pharmacognosy THE UNIVERSITY OF LAHORE
  2. 2. What are lignans and Neolignans  What are their sources  Role of lignans and neolignans in plants and human body 
  3. 3. PHYTOESTROGENS (substances found in plants having estrogen like activities) COUMESTANS ISOFLAVONES
  4. 4.  In 1936, Haworth defined lignans as “Phenylpropanoid dimers consisting of two phenyl propane units (C6C3) linked by their central C8 carbon.”
  5. 5. Phenylpropane unit Lignan
  6. 6.  In 1972, Gottileib defined neolignan as “Phenylpropanoid dimers consisting of two phenylpropane units (C6C3) linked in a manner other than C8-C8' linkage”
  7. 7.  Widely  distributed in plants. Usually occur in root, stem, bark, fruits and seed parts of plant.
  8. 8. FLAX SEEDS: 1.   Secoisolariciresinol Diglucoside (SDG) 1 ounce of flaxseed contains 85mg of lignans
  9. 9.  Sesamin 1 ounce of sesame seeds contain 11 mg of lignans
  10. 10.  Secoisolariciresinol
  11. 11.  Larisiresinol
  12. 12. SOURCES LIGNANS Wheat 7-hydroxymatairesinol Corn 7-hydroxymatairesinol Strawberry Pinoresinol Pea Pinoresinol Broccoli Larisiresinol
  13. 13. Plant lignans Intestinal bacteria Mammalian lignans or Enterolignans (enterolactone, enterodiol)
  14. 14. Narrow distribution  Isolated from magnoliales and piperales.  Neolignans isolated from stem bark of Magnolia obovata are  Magnolol  Honokiol  4-methoxyhonokiol  Obovatol  Neolignan isolated from stem of Piper kadsura  Kadsurenone 
  15. 15.  Participate in defensive mechanism against pathogens due to its antiviral, anti-bacterial and anti-fungal properties.
  16. 16.  Steroidal hormone mainly present in females but also in men.  Mainly secreted by ovaries, minute quantity by adrenal cortex.  3 forms: estradiol, estrone, estriol.  Synthesized from cholesterol and transported by albumin and globulin in plasma.  Role in maturation of sperms in males.
  17. 17.  Promote cellular proliferation and tissue growth.  Contribute to development of secondary sexual characters (hair distribution, voice, body shape)  Increases osteoblastic activity and thus its lack lead to osteoporosis.  Increases fat deposition in subcutaneous tissues  Causes the skin to develop a texture that is soft and smooth
  18. 18.  Estrogens bind with estrogen receptors and form hormone-receptor complex which in turn binds with DNA and induces transcription of mRNA.  2 types of estrogen receptors 1. ER-α (uterus, heart, liver, kidneys) 2. ER-β (ovaries, other tissues)
  19. 19.  ESTROGEN RECEPTOR – DEPENDENT ACTIVITIES:  Phytoestrogens bind to estrogen receptors and either  Mimic the estrogenic effects (low dose)  Antagonizes the estrogenic effects(high dose)  Anti-estrogenic activity is important in prevention of cancer.
  20. 20.  Estrogens contribute to cause breast cancer by stimulating the proliferation of breast cells.
  21. 21.  High blood levels of enterolactone are associated with a lower incidence of breast cancer.  The new study, published in EUROPEAN JOURNAL OF CANCER PREVENTION reports that women with high plasma level of enterolactone was associated with 58% reduction in breast cancer risk.  34% in breast cancer cell growth after giving SDG daily for 30 days.
  22. 22. A new study from SWEDEN concluded that diet rich in lignans could reduce the risk of prostate cancer risk by 26%  The in-vitro study from NEWZEALAND report that enterolactone may prevent spread of prostate cancer by regulating genes which produce important effects on apoptosis of prostate cancer cells.
  23. 23.  In a case-control study of lignans and endometrial cancer, U.S. women with the highest intakes of plant lignans had the lowest risk of endometrial and ovarian cancer, but the reduction in risk was statistically significant in postmenopausal women only.
  24. 24.  Enterolactone helps with estrogen balance, researchers have found that it is a safe and natural alternative to help buffer the hormonal fluctuations during menopause. This in turn helps to alleviate the accompanying symptoms of hot flashes and night sweats.
  25. 25.  ANTI-OXIDANT EFFECT Lignans exhibit very strong antioxidant properties, thus it can protect the body from the effects of oxidation which can lead to a series of chronic diseases.
  26. 26.  Increased blood levels of enterolactone have been shown to reduce oxidation of blood lipids and reduce risk of heart disease by offering antioxidant and antiinflammatory protection.
  27. 27. TESTOSTERONE INHIBIT 5-alpha reductase DHT (DIHYDROTESTOSTERONE) INHIBIT HAIR LOSS AND ACNE
  28. 28.  Lignans suppresses the integration of proviral DNA into cellular genome.
  29. 29.  ANTI-MICROBIAL EFFECT  Anti-bacterial effect  Anti-fungal effect  INHIBITION OF PLATELET ACTIVTING FACTOR  Kadsurenone antagonizes the activity of PAF
  30. 30.  Honokiol and magnolol have been evaluated as antioxidants. These neolignans protected mitochondrial respiratory chain enzyme activity against NADPH-induced per oxidative stress and protected red cells against oxidative haemolysis.
  31. 31.  Magnolol has depressant and effects. showed antianxiety reduced

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