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823998 structure-of-ampiphatic-lipids-and-the-different-complexes
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823998 structure-of-ampiphatic-lipids-and-the-different-complexes

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    823998 structure-of-ampiphatic-lipids-and-the-different-complexes 823998 structure-of-ampiphatic-lipids-and-the-different-complexes Presentation Transcript

    • www.Examville.com Online practice tests, live classes, tutoring, study guides Q&A, premium content and more .
    •  
      • lipids are insoluble (hydrophobic) in water
      • due to the predominant presence of hydrocarbon groups
      • however, some possess polar or hydrophilic groups which tend to be soluble in water
      • molecules which contain both hydrophobic and hydrophilic groups
      • (Greek – amphi – (both), pathos – passion)
      amphipathic
      • Examples:
      •  
      • Fatty acids
      • Phospholipids
      • Sphingolipids
      • Bile salts
      • Cholesterol (to some extent)
      • Fatty Acids – contain a hydrocarbon chain which is hydrophobic and a carboxyl (COO¯) group which is hydrophilic
      • Phospholipids – have a hydrophilic head
      • ( phosphate group attached to choline, ethanolamine, inositol etc.) and a long hydrophobic tail
      • when the amphipathic lipids are mixed in water
      • (aqueous phase)
      • the polar groups (heads) orient themselves towards aqueous phase while the non polar (tails) orient towards the opposite directions
      •  
      •  
      • leads to the formation of micelles
      •  
      •  
      • micelle formation, facilitated by bile salts is very important for lipid digestion & absorption
      • represented as a polar or hydrophilic head with a non-polar or hydrophobic tail
      • in case of biological membranes, a bilayer of lipids is formed orienting the polar heads to the outer aqueous phase on either side and the nonpolar tails into the interior
      • the formation of a lipid bilayer is the basis of membrane structure
    •  
    •  
      • are produced when amphipathic lipids in aqueous medium are subjected to sonifications
      • they have intermittent aqueous phases in the lipid bilayer
      • liposomes in combination with tissue specific antigens are used as carriers of drugs to target tissues
      • are produced when non polar lipids (e.g. triacylglycerols) are mixed with water
      • the particles are larger in size and stabilized by emulsifying agents (usually amphipathic lipids, - bile salts & phospholipids )
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