Protein structure and synthesis - Classroom activities

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Proteins and peptides are organic compounds made of amino acids. In nature, proteins
are synthesised from the information codified in genes, but proteins can also be synthesized in the lab
by means of chemical methods. In this unit you will learn about amino acids and protein synthesis.

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Protein structure and synthesis - Classroom activities

  1. 1. Teaching Unit 8Protein structure and synthesisKeywords and concepts: Proteins. Protein synthesis. Amino acids. Peptides.’Xplore Health related tools: Virtual experiment: Develop a drug!Introduction: Proteins and peptides are organic compounds made of amino acids. In nature, proteinsare synthesised from the information codified in genes, but proteins can also be synthesized in the labby means of chemical methods. In this unit you will learn about amino acids and protein synthesis.ACTIVITY 1 The following drawing represents one of the stages of the virtual experiment “Develop a drug”; find a title for it. Next, explain the process depicted in the drawing and write the names of the different components that appear in the drawing.AUTHOR: FUNDED BY: Teaching Unit 8 -1-
  2. 2. ACTIVITY 2The POP inhibitor that you have synthesized in the virtual experiment is a peptide made of threeamino acids: Ala-Gly-Cis. a) Find the structures of Alanine, Glycine and Cystine and draw them. To what groups of amino acids do they belong? Why? b) Which bond binds them together?AUTHOR: FUNDED BY: Teaching Unit 8 -2-
  3. 3. c) Draw the Ala-Gly-Cis tripeptide. d) How many different peptides could you build with these 2 amino acids?ACTIVITY 3 Construct a representation of the POP inhibitor with recycled materials, with objects that you find at home, with plastiline, with paints, etc. Your representation must be original and it must help understand the process that you want to depict. Take a photograph and send it with an explanation to the following email address: xplorehealth@pcb.ub.cat. The photographs will be published in Xplore Health.AUTHOR: FUNDED BY: Teaching Unit 8 -3-
  4. 4. ACTIVITY 4 Complete the following Sudoku puzzle with the missing amino acids. Please remember that each row, each column and each square must contain the 9 amino acids: Ala, Gly, Cis, Thr, Ile, Leu, Phe, Val and His. Ile Thr Cis Leu Phe Leu Val Gly Ala Ile Cis Phe Thr Leu Val Gly Val Ile Thr Leu Ile Cis Cis Ile His Phe Thr His Ile Gly Leu Gly IleAUTHOR: FUNDED BY: Teaching Unit 8 -4-
  5. 5. Answer: Cis Ile Leu Gly Ala Thr His Val Phe Val Gly Ala Cis His Phe Leu Ile Thr Phe Thr His Leu Ile Val Cis Gly Ala Ile Cis Phe Thr Gly Leu Val Ala His Gly Ala Val His Phe Cis Ile Thr Leu His Leu Thr Ala Val Ile Gly Phe Cis Ala Val Cis Ile Thr His Phe Leu Gly Thr His Ile Phe Leu Gly Ala Cis Val Leu Phe Gly Val Cis Ala Thr His IleAUTHOR: FUNDED BY: Teaching Unit 8 -5-

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