Needle Free Injectors

Needle Free Injection Technology Advantages of Needle Free Injection Systems

Needle Free Injection Technology Audience
Medical & Health Boards
Humanitarian Foundations and Organizations
I represent manufacturers and developers of needle free injection technology.

Needle Free Injection Technology Companies

Needle Free Injections Introduction
I’m here to speak to you about needles,
boosters, vaccinations, flu shots
We’ve all had to get them
Most of us don’t like them
Some people cry, get scared or even faint
Introduction Current Ideal Proposed Conclusion

Goal of this presentation:
Present alternative methods of medication delivery.
Discuss the features and advantages of needle free injection systems over traditional hypodermic needles in the administration of serums, vaccinations and other medicines.

The Problem
Vaccinations & inoculations
The Current Method
Hypodermic needles
The Ideal Solution
Efficient, cost effective
The Proposed Method
Needle free injectors

Needle Free Injections Contents
1. Current Method
Hypodermic Needles
Development
Description
Advantages
Problems
2. Ideal Solution
3. Proposed Solution
Alternative Delivery
Systems
Needle Free Injectors
Development
Description
Advantages
Problems
4. Conclusion

Needle Free Injections 1. Current
The Current Method
Liquid serums
Needle and syringe
Sterile equipment
Well trained staff
Cultural challenges to
needles

Needle Free Injections Development
Hypodermic Needle - a brief history
1844 Irish physician Francis Rynd invented the hollow needle.
1853 French physician Charles Pravaz & Edinburgh physician Alexander Wood independently developed the first practical metal syringe adding a hollow needle to the end of a glass syringe.

An Early Hypodermic Needle
Glass tube & plunger Hollow steel needle Introduction Current Ideal Proposed Conclusion

Needle Free Injections Description
The Modern Hypodermic Needle
Plastic Syringe & Plunger Stainless Steel Needle in Plastic Tip Introduction Current Ideal Proposed Conclusion

Needle Free Injections Advantages
Hypodermic Needles are
Inexpensive – needle & syringe
Versatile – wide variety of medicines
Familiar – well known technology
Scaleable – various syringe sizes accommodate different doses
( $22.95 for 100 1cc size)
($41.75 for 100 5cc size)
($42.75 for 100 10cc size )

Needle Free Injections Problems
Hypodermic Needle problems
Needlephobia
Substantial training required
Difficult to insert needle to correct depth
Necessary to aspirate the needle to ensure not hitting a blood vessel
Keeping the needle steady

Hypodermic Needle problems
Danger of being stuck by used needle
Disposal of needle tips called “sharps”
Medication waste & ineffective treatment if delivered to improper depth
Possible re-use of needles

Needle Free Injections 2. Ideal Solution
Ideal Solution
Inexpensive
Low-level of Training
Powdered medication (refrigeration, transport)
Non invasive (nothing penetrates the skin except the medicine)
Dispel Needlephobia
Disposable (no reuse or accidental stick injuries)

Needle Free Injections 3. Proposed Solution
The Proposed Method
Needle Free Injection Technology
Safe, clean, efficient
Easy to use, reliable
Various types of medicines

Needle Free Injections Alternates
Alternative medication delivery systems include:
nasal sprays and drops
skin patches such as nitroglycerin patches for heart patients
inhalers for asthma which deliver pre-measured doses into the lungs for rapid absorption into the bloodstream
edible vaccine-packed vegetables (in 1998 potatoes developed with genes from the cholera virus to protect against cholera)

Needle Free Injector Systems
1940s & 1950s air powered injector systems
Gun shaped used propellant gases to force drugs into the skin
Multiple inoculations in the
military and developing nations
Reusable – risk of infection

Needle free injectors improved
By the 1990s
single dose from serum reservoir
disposable nozzle
use existing medications
inject liquid or powder
self contained propulsion
The Cool Click from Bioject Introduction Current Ideal Proposed Conclusion

How Needle Free Injectors Work
force medication at high speed through a tiny hole that is held against the skin
ultra-fine stream of high-pressure fluid or powder penetrates the skin to various depths
intradermal, subcutaneous, & intramuscular

Injection modes
Intradermal – very shallow between layers of skin
Subcutaneous – adipose or into the fat layer of the skin
Intramuscular – deepest type, into muscle tissue
Intradermal Subcutaneous Intramuscular Introduction Current Ideal Proposed Conclusion

Injector design: 3 components
Injection device – hand held durable plastic
Disposable needle free syringe – only part that touches the skin, sterilized and disposable after injection
Air cartridge – pressurized metal air cartridge in portable units
- larger air container hook ups for in-office systems

Injector design:
Crossject uses the impact of a spring triggered by the nozzle touching the skin to activate energetic materials which produce gas to inject the serum.
Other systems use a re-usable spring to generate the pushing force instead of air.

The Crossject Bioject 2000 System
System
Disposable syringe CO2 Cartridge Bioject 2000 Injector Bioject Gas Tank Attachment Introduction Current Ideal Proposed Conclusion

Advantages:
less drug required to inject the same volume
approximately 8% savings in vaccine
improved diffusion and more reliable depth of penetration
reliable penetration means more efficient use of drugs

Advantages:
improved safety and protecting against infection
higher self-treatment rates
operate with existing formulations which reduces development and clinical trials, and that equals savings

Needle Free Injectors however…
are more expensive, for example:

Biojector® 2000 Injector $1200.00 S ingle use, sterile, disposable needle-free syringes $200.00 (100 syringes per box) B ox of CO 2 power cartridges $8.00 (10 CO 2 cartridges per box) Introduction Current Ideal Proposed Conclusion

Needle Free Injections Conclusion
Recap:
Hypodermic Needles
difficult to master (training)
not always effective
safety issues (stick injuries, reuse)
disposal issues
just not well liked (needlephobia)
inexpensive

Recap:
safe & sterile
use existing meds & new developments
less medicine required
reliable depth of penetration
efficient use of medication
patients like them and use them (self treatment)
not inexpensive

Conclusion:
Needle Free Injectors are more reliable, easier to use, more efficient, much safer and have no disposal problems. Acceptance by patients, continuing developments and lowering costs all make needle free systems the best method for vaccinations, insulin self-treatments, and large or small scale inoculations.

Needle Free Injection Technology Thank you

Needle Free Injectors

by Ron Thomson

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