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Down regulation and addiction-most updated

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Addiction and the brain

Addiction and the brain

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  • Slide 2: Brain regions and neuronal pathways Certain parts of the brain govern specific functions. Point to sensory, motor, association and visual cortex to highlight specific functions. Point to the cerebellum for coordination and to the hippocampus for memory. Indicate that nerve cells or neurons travel from one area to another via pathways to send and integrate information. Show, for example, the reward pathway. Start at the ventral tegmental area (VTA) (in magenta), follow the neuron to the nucleus accumbens, and then on to prefrontal cortex. Explain that this pathway gets activated when a person receives positive reinforcement for certain behaviors ("reward"). Indicate that you will explain how this happens when a person takes an addictive drug.
  • Slide 3: Neuronal Structure Remind the student that pathways are made up of neurons. Describe the anatomy of a neuron (soma, dendrites and axon are marked with text). State that this neuron is real - as viewed through a microscope. Explain the normal direction of impulse flow. Dendrites and soma receive chemical information from neighboring neuronal axons. The chemical information is converted to electrical currents which travel toward and converge on the soma. A major impulse is produced (the action potential) and travels down the axon toward the terminal. Point to the terminal.
  • Slide 4: The synapse and synaptic neurotransmission Describe the synapse and the process of chemical neurotransmission. Indicate how vesicles containing a neurotransmitter, such as dopamine (the stars), move toward the presynaptic membrane as an electrical impulse arrives at the terminal. Describe the process of dopamine release (show how the vesicles fuse with the presynaptic membrane). Once inside the synaptic cleft, the dopamine can bind to specific proteins called dopamine receptors (in blue) on the membrane of a neighboring neuron. Introduce the idea that occupation of receptors by neurotransmitters causes various actions in the cell; activation or inhibition of enzymes, entry or exit of certain ions. State that you will describe how this happens in a few moments.
  • Slide 5: Dopamine neurotransmission Using the close-up of a synapse, continue using dopamine for your example of synaptic function. Explain that it is synthesized in the nerve terminal and packaged in vesicles. Reiterate the steps in neurotransmission. Show how the vesicle fuses with the membrane and releases dopamine. The dopamine molecules can then bind to a dopamine receptor (in blue). After the dopamine binds, it comes off the receptor and is removed from the synaptic cleft by uptake pumps (also proteins) (in red) that reside on the terminal. This process is important so that not too much dopamine is left in the synaptic cleft at any one time. Also point out that there is a neighboring neuron, which releases another compound called a neuromodulator. In this case it is an "endorphin" (blue flying saucers). Endorphins bind to opiate receptors (in green) which reside on the post-synaptic cell or in some cases on the terminals of other neurons (this is not shown so it must be pointed out). The endorphins are destroyed by enzymes rather than removed by uptake pumps.
  • Slide 10: Injection of cocaine into the nucleus accumbens Demonstrate how scientists located the structures important for the addictive nature of drugs. Show that a rat will self-administer cocaine directly into the nucleus accumbens (or the VTA) to activate the pathway. Point to an area close to the nucleus accumbens or VTA and state that if the injection is placed in this other area, the rat will not press the lever to receive the drug. Indicate that scientists know a lot more than where the drug acts to produce rewarding effects - they also know how the drugs work. Show examples with cocaine, heroin and marijuana.
  • Transcript

    • 1. Addiction and the Brain
    • 2. The Least You Need To Know:• Neurotransmitters (define)• reward pathway (define)• Old brain vs. New brain (general)• down-regulation (describe)• oops phenomenon (general)• drug use continuum (when addicted?)
    • 3. Choice orDisease?
    • 4. Substance Abuse: The Nation’s Number One Health iProblem ted e in the Un f substa nce abus i cally, are Th e costs o and phys nomically onomically S tates, eco hol is the most ec t lc o s moking a st ag gering. A l lowed by billion, fo illion, the at $166.5 at $110 bcostly d rug abuse he more than 2$138 b illion and more, of t her ates, one report said. Furt e United St each year in th obacco an dmillio n deaths alcohol, t ri butable to in f our is att drug use. i l l i ci t Robert Wood Johnson Foundation, 2006
    • 5. “Drug Addiction is a Brain Disease” Alan Leshner, PhD National Institute of Drug Abuse Former Director
    • 6. The Beginning of Brain Research Trepanized skulls 1848
    • 7. How the Brain Communicates• Neurons -100 billion!—nerve cells that work nonstop to send and receive messages.• Neurotransmitters—The Brains Chemical Messengers that travel across the space (called the synapse) binds to receptors on the nearby neuron.• Receptors—The Brains Chemical Receivers A neurotransmitter and its receptor operate like a key and lock.• Transporters—The Brain’s Chemical Recyclers Once neurotransmitters do their job, they are pulled back (recycling process shuts off signal) between the neurons.
    • 8. Neurotransmitters: Chemical Messengers
    • 9. Intro: Mouse Party -Link-
    • 10. The Big Two:• Serotonin: mood, emotion, sleep and appetite• Dopamine: pleasure and elation
    • 11. Many drugs work by mimicking a naturally occurringneurotransmitter in the body.
    • 12. Release of Dopamine in the Rat Nucleus Accumbens: Acute Administration 300Dopamine (% Change) 250 Footshock Sucrose Cocaine 200 Nicotine Alcohol 150 100 50 0 60 120 180 240 Time (min) Kalivas, P. 2002
    • 13. OLD BRAIN VS. NEW BRAIN
    • 14. Transition to Addiction Good to Bad• Increased Energy “It sustains and refreshes both body and brain...... in the same space of time more than double the amount of Replace Natural Reward "A work could be undergone...” Sears, coke shot...its like... Roebuck, and Co. Consumers Guide, 1900 Craving “I found I was taking money• Euphoria “.....exhilarating and meant to buy presents for my children.” lasting euphoria.... You perceive increase in self-control and possess Paranoia “He thought he was being forcibly electrocuted and could see more vitality and capacity for work.” electric wires leading to his body.” Sigmund Freud, 1884
    • 15. Oops Phenomenon• First use to Feel Good• Some continue to compulsively use because of the reinforcing effects – To Feel Normal• Changes occur in the reward system that promote continued use.
    • 16. Something truly scary….?If you remember one thing about drugs….
    • 17. National Institute on Drug Abuse, 2002; Monkey Brain
    • 18. • The Pathology of Addiction (Start 3:05)
    • 19. What is Down-Regulation?National Institute on Drug Abuse, 2000
    • 20. PET/fMRI of Cocaine Craving Childress et al., 1999; Am.J.Psychiat
    • 21. ‘Down’ in the DumpsDown-Regulation• Immediate effect of drug use is an increase in dopamine or NT’s• Continued use of drugs reduces the brain’s dopamine (or NT) production.• Because dopamine is part of the reward system, the brain is “fooled” that the drug has survival value for the organism.• The reward system responds with “drug seeking behaviors”
    • 22. Relapse or Recidivism Why 8-9 out of 10? Or around 80-90%...Go back to using!
    • 23. The face of addiction:http://www.youtube.com/watch?v=02ngAsHRg4A
    • 24. Imagine……
    • 25. DRUG USE CONTINUUMAbstinence Experimentation Drug Use Drug Abuse Addiction
    • 26. • Deep Processing Organizer• Due End of Class• Midterm Tomorrow• Cumulative (1st 3 Units)• Review(s) Available online
    • 27. Essential Questions• So…is addiction a Choice or disease?• How are depression and drug use related?• How does someone become an ‘addict?’
    • 28. http://www.youtube.com/watch?v=de