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Wst chem21

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  • 1. Getting the message acrossDr Will Stahl-TimminsAssociate Research Fellow
  • 2. ECEHH - European Centre for Environment and Human HealthGraphic 1 - Pharma Transport TownGraphic 2 - GOfER
  • 3. ECEHH - European Centre for Environment and Human HealthGraphic 1 - Pharma Transport TownGraphic 2 - GOfER
  • 4. ECEHH - European Centre for Environment and Human HealthGraphic 1 - Pharma Transport TownGraphic 2 - GOfER
  • 5. Future plans: Policy version (EEA) Health Professionals versionGeneral Public version (exhibit)
  • 6. ECEHH - European Centre for Environment and Human HealthGraphic 1 - Pharma Transport TownGraphic 2 - GOfER
  • 7. GOfERGraphical Overview for Evidence Reviews
  • 8. outcome measures used no. of design, size baseline study cog func be glo author location centres & follow-up MMSE sex ages quality ADCS-ADL ADCS-CGIC ADAS-cog other other other CIBIC MMSE DAD PDS CDR QoL SIB NPI GDS 0yr 1 2 0 10 20 30 55 75 95 Donepezil 1mg N = 42 M F Rogers & Rand Donepezil 3mg N = 40 M F ? N = 161 Donepezil 5mg N = 39 M F Char Blind Analy 1mg 3mg 1996 F Placebo N = 40 M 5mg Donepezil 5mg N = 154 M F 5mgRogers et al. Rand M F Char 10 Donepezil 10mg N = 157 Blind mg 1998 (A) N = 473 Analy M F Placebo N = 162 Donepezil 5mg N = 157 M F 5mgRogers et al. Rand M F Char 10 Donepezil 10mg N = 158 mg Blind 1998 (B) N = 468 Analy M F Placebo N = 153 Donepezil 5mg N = 271 M F 5mg Burns et al. Rand M F Char 10mg Donepezil 10mg N = 273 Blind 1999 Analy N = 818 M F Placebo N = 274 Greenberg Donepezil 5mg (D) Rand et al. group 1 (p-D-p-p) N=30 M F Char group 2 (p-p-D-p) N=30 M F Blind N = 60 Analy 2000 Placebo (p) Donepezil 5mg N = 134Homma et al. M F Rand Char Blind 2000 N = 268 M F Analy Placebo N = 129 Donepezil 10mg N = 214 Mohs et al. M F Rand Char ADCS-CGIC ADCS-ADL Blind ADAS-cog 2001 N = 431 M F Analy MMSE CIBIC Placebo N = 217 DAD other other other CDR GDS PDS QoL NPI SIB 0yr 1 2 0 10 20 30 55 75 95 cog func be glo
  • 9. Mean task time(% of total task time) Error Bars: 95% CI 20% 15% two-sample t(69) = 4.4 p < 0.001 10% 5% 0% Report GOfER COGS
  • 10. task accuracy GOfER: 74.3% report: 46.4%c2 (1, N = 63) = 5.12, p = 0.024
  • 11. outcome measures used no. of design, size baseline study cog func be glo author location centres & follow-up MMSE sex ages quality ADCS-ADL ADCS-CGIC ADAS-cog other other other CIBIC MMSE DAD PDS CDR QoL SIB NPI GDS 0yr 1 2 0 10 20 30 55 75 95 Donepezil 1mg N = 42 M F Rogers & Rand Donepezil 3mg N = 40 M F ? N = 161 Donepezil 5mg N = 39 M F Char Blind Analy 1mg 3mg 1996 F Placebo N = 40 M 5mg Donepezil 5mg N = 154 M F 5mgRogers et al. Rand M F Char 10 Donepezil 10mg N = 157 Blind mg 1998 (A) N = 473 Analy M F Placebo N = 162 Donepezil 5mg N = 157 M F 5mgRogers et al. Rand M F Char 10 Donepezil 10mg N = 158 mg Blind 1998 (B) N = 468 Analy M F Placebo N = 153 Donepezil 5mg N = 271 M F 5mg Burns et al. Rand M F Char 10mg Donepezil 10mg N = 273 Blind 1999 Analy N = 818 M F Placebo N = 274 Greenberg Donepezil 5mg (D) Rand et al. group 1 (p-D-p-p) N=30 M F Char group 2 (p-p-D-p) N=30 M F Blind N = 60 Analy 2000 Placebo (p) Donepezil 5mg N = 134Homma et al. M F Rand Char Blind 2000 N = 268 M F Analy Placebo N = 129 Donepezil 10mg N = 214 Mohs et al. M F Rand Char ADCS-CGIC ADCS-ADL Blind ADAS-cog 2001 N = 431 M F Analy MMSE CIBIC Placebo N = 217 DAD other other other CDR GDS PDS QoL NPI SIB 0yr 1 2 0 10 20 30 55 75 95 cog func be glo
  • 12. ECEHH - European Centre for Environment and Human HealthGraphic 1 - Pharma Transport TownGraphic 2 - GOfER
  • 13. w.stahl-timmins@exeter.ac.ukwww.ecehh.orgblog.willstahl.comTwitter: @will_s_t