Integrating advances in exposure science and toxicity testing next steps
- 1,170 views
Findings from the workshop are...
Findings from the workshop are
detailed in this report; key outcomes
include the following:
• Advances in molecular technologies are enabling environmental epidemiology and toxicology to
identify the exposure-effect relationship at the cellular, organismal, and population levels.
• The success of these approaches hinges on the availability of biologically-relevant exposure
information that is rapidly evolving from improved measurement technologies, more targeted
biomonitoring studies, and applications of advanced informatics and computational tools.
• The exposome, defined as a lifetime of human environmental exposures including lifestyle
factors, was highlighted as a possible framework for guiding developments in exposure science.
• Stem cells offer great potential for the development of in vitro toxicity models that are relevant to
effects that can occur in humans; similarly, new imaging methods offer innovative approaches to
understand mechanisms of toxicity in in vitro models.
• Computational models are becoming increasingly sophisticated and advanced both in the
analysis of ‘omics’ data, such as high throughput methods, as well as in their predictive
capabilities, such as for biological system interactions and (quantitative) structure- activity
relationship [(Q)SAR] modeling.
• New informational tools, including the Toxicological Priority Index (ToxPi) and the Chemical
Screening Visualization Tool (CVST), can incorporate and transform multiple types of chemicalinformation into visual formats that facilitate chemical prioritization and identification of areas for
additional toxicity testing.
• Value of information (VOI) methods and other decision analysis tools provide an approach for
identifying those test protocols that offer the best value in terms of resource allocation.
• Effective communication about chemicals must include both risk and benefit information so that
all shareholders, including the public, are fully informed.
• Risk characterization is an analytical, deliberative, and decision-driven process; successful
characterization of risk for chemicals requires getting the science and the participation right as
well as getting the right science and the right participation.
• Stakeholders must be part of the risk assessment process to improve credibility and the utility of
the results; input, dialogue,
- Total Views
- Views on SlideShare
- Embed Views