The terms thrombocytopenia refer to a relativedecrease of platelets in blood.
CAUSES Vitamin B12 or folic acid deficiency Idiopathic thrombocytopenic purpura Thrombocytopenia-inducing medications Increased destruction Decreased production of thrombopoietin by the liverin liver failure Leukemia or myelodysplastic syndrome
SIGNS AND SYMPTOMS Occasionally, there may bebruising , particularlypurpura in the forearms,petechia (pinpointhemorrhages on skin andmucous membranes),nosebleeds and/orbleeding gumsA person with this disease mayalso complain of malaise, fatigue,and general weakness (with orwithout accompanying bloodloss).
TREATMENT The main concept in treating thrombocytopenia is toeliminate the underlying problem, whether thatmeans discontinuing suspected drugs that causethrombocytopenia, or treating underlying sepsis.
Thrombocytopenia affects a few percent ofnewborns, and its prevalence in neonatal intensivecare units is high. Most of the cases of thrombocytopenia affectpreterm birth infants and are results of placentalinsufficiency and/or fetal hypoxia.