Vitiligo affects 0.5-4% of the World population.
The disease generally begins between the ages of 2 and 40.
In a Dutch study, 50% of patients reported the occurrence before the age of 20.Adults and children of both sex are equally affected
The greater number of reports among females is probably due to greater social consequence to woman and girls affected by this condition.
50% of patients before the age of 20
25% of patients before the age of 8
Loss or reduction of melanocytes
Reduced melanine production from melanocytes (altered tyrosinase activity, altered structure/activity of rough endoplasmic reticulum, lack of specific melanocyte receptors…)
Decreased melanine transfer from melanocytes to keratinocytes
Primary disorder of keratinocytes