Permanent skin depigmentation

1,366 views

Published on

Permanent skin depigmentation
Martina Barbarin

- Disclaimer-

This PPT is loaded as student material "as is", from the VRF Vitiligo Master Class Barcelona November 2011; VRF does not endorse or otherwise approve it.

0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total views
1,366
On SlideShare
0
From Embeds
0
Number of Embeds
2
Actions
Shares
0
Downloads
18
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide

Permanent skin depigmentation

  1. 1. Permanent skin depigmentation Barbarin M. Faculty Hospital in Nitra, Department of Dermatology, Nitra, Slovakia
  2. 2. Objective: <ul><li>Permanent skin depigmentation is considered in patients with generalized vitiligo />50%/ unaffected skin is lightened to achieve a more uniform appearance. </li></ul>
  3. 3. Methods: <ul><li>Chemical permanent skin depigmentation uses Monobenzylether of Hydroquinone </li></ul><ul><li>Benoquin Cream /20% of MBEH/: </li></ul><ul><li>- is applied topically </li></ul><ul><li>- twice daily </li></ul><ul><li>- 3 to 12 months </li></ul><ul><li>KI: pregnanancy, brestfeeding </li></ul>
  4. 4. Results: <ul><li>The pigment removal with 20%MBEH: </li></ul><ul><li>- only for vitiligo patient </li></ul><ul><li>- is permanent </li></ul><ul><li>- produces a chalk- white color </li></ul><ul><li>- makes the skin vulneralble to </li></ul><ul><li>the sunlight and needs protection </li></ul><ul><li>/umbrella, long sleeves, hat/ </li></ul>
  5. 5. Case: <ul><li>Michael Jackson </li></ul><ul><li>in 1986 diagnosed with </li></ul><ul><li>vitiligo and discoid LE </li></ul><ul><li>FH: vitiligo+ </li></ul><ul><li>In the early 90s: </li></ul><ul><li>- discolorations covered most of the body </li></ul><ul><li>- he went throught the permanent skin </li></ul><ul><li>depigmentation /20% MBEH, it took </li></ul><ul><li>about a year/ </li></ul>
  6. 6. Chemicals effective in skin whitening <ul><li>Pre-melanin synthesis: </li></ul><ul><li>Tretinoin 0,05-0,1% crm ./retinoic acid/ </li></ul><ul><li>-makes the skin more sensitive to UVA,UVB- avoide sunlight </li></ul><ul><li>During melanin synthesis: </li></ul><ul><li>Hydroquinon 2%, 4% crm ./irrit./ popular for last 40 years </li></ul><ul><li>-EU banned it from cosmetics in 2001 </li></ul><ul><li>Arbutin /safe natural source of hydroquinon in pears,berrys/ </li></ul><ul><li>Kojic acid /fungal metabolit, in fermentation process of sake/ </li></ul><ul><li>Azelaic acid 20% crm ./in grains-wheat,barley, is produced by Pityrosporum ovale/ </li></ul><ul><li>Vitamin C >5% </li></ul><ul><li>Post-melanin synthesis: </li></ul><ul><li>Alpha hydroxy acids /AHA/ >5O% facial peels </li></ul>
  7. 7. Other Laser treatments - ablative and nonablative /melasma/ Liquid N - excess melanin comes to the surface and peels off in a few days Oral suplements of pomegranate extract, ellagic acid, vit.E, ferulic acid,, soyabean /inhibit melanine production/. Long term use of skin whiteners can lead to pigmentation increasing to the joints of the -fingers -toes -buttocks and ears. The skin of the face can become -thinned -the area around the eyes can have increased pigmentation causing a „bleach panda effect“.
  8. 8. Thank you

×